Results 1 to 10 of about 345,927 (108)

RNA Polymerase III Regulates HIV Replication and Latency [PDF]

Viruses
The elimination of HIV latent reservoirs is an extremely challenging task due to the interplay of multiple mechanisms regulating latency. Thus, we need to identify novel strategies to target heterogeneous reservoirs uniformly.
Landon Thompson, Imran Jamal, Juthika Das, Casey Dang, Zhenzi Hong, Doran Katz, Alberto Bosque, Vir B. Singh   +7 more
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Human RNA polymerase III termination favors decomposition over facilitated recycling [PDF]

Nature Communications
Eukaryotic transcription termination remains incompletely understood. Using single-molecule fluorescence assays, we examined intrinsic termination by human RNA polymerase III (RNAP3) and identified mechanistic trifurcation leading to readthrough and two ...
Sun Han, Qianmin Wang, Eunho Song, Changwon Kang, Yanhui Xu, Sungchul Hohng   +5 more
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Computationally derived RNA polymerase III promoters enable maize genome editing [PDF]

Frontiers in Plant Science
CRISPR endonucleases require cognate non-coding RNA species for site-specific activity. These RNA species are typically expressed using endogenous RNA polymerase III (Pol III) promoters compatible with the host species.
Ervin D. Nagy, Ian W. Davis, Shanshan Song, Valerie No, Chenxi Wu, Lisa Kanizay, Sarah Turner-Hissong, Hong Li, Xudong Ye, Jeffrey C. Berry, Brandi Chiapelli, Jennifer P. C. To, Matthew S. Marengo   +12 more
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RNA polymerase III is involved in regulating Plasmodium falciparum virulence [PDF]

eLife
While often undetected and untreated, persistent seasonal asymptomatic malaria infections remain a global public health problem. Despite the presence of parasites in the peripheral blood, no symptoms develop.
Gretchen Diffendall, Aurelie Claes, Anna Barcons-Simon, Prince Nyarko, Florent Dingli, Miguel M Santos, Damarys Loew, Antoine Claessens, Artur Scherf   +8 more
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Analysis of RNA Transcribed by RNA Polymerase III from B2 SINEs in Mouse Cells [PDF]

Non-Coding RNA
Background/Objectives: SINEs (short interspersed elements) are eukaryotic non-autonomous retrotransposons. They are transcribed by RNA polymerase III (pol III) and generate non-coding RNAs.
Olga R. Borodulina, Sergey A. Kosushkin, Ilia G. Ustyantsev, Nikita S. Vassetzky, Dmitri A. Kramerov   +4 more
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Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing [PDF]

Nature Communications
RNA polymerase III (Pol III) transcribes cytosolic transfer RNAs (tRNAs) and other non-coding RNAs (ncRNAs) essential to cellular function. However, many aspects of Pol III transcription and processing, including RNA modifications, remain poorly ...
Ruth Verstraten, Pierina Cetraro, Amy H. Fitzpatrick, Yasmine Alwie, Yannick N. Frommeyer, Elene Loliashvili, Saskia C. Stein, Susanne Häussler, Werner J. D. Ouwendijk, Daniel P. Depledge   +9 more
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Decreased RNA polymerase III subunit expression leads to defects in oligodendrocyte development [PDF]

Frontiers in Neuroscience, 2023
IntroductionRNA polymerase III (Pol III) is a critical enzymatic complex tasked with the transcription of ubiquitous non-coding RNAs including 5S rRNA and all tRNA genes.
Julia Macintosh, Julia Macintosh, Mackenzie Michell-Robinson, Mackenzie Michell-Robinson, Xiaoru Chen, Xiaoru Chen, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard   +10 more
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Engineered mouse H1 promoter mutants with superior RNA polymerase III activity [PDF]

Biochemistry and Biophysics Reports
Vectors incorporating the human H1 (hH1) promoter are being applied for RNA interference (RNAi) experiments and genome editing. Although extensive studies have been conducted on the hH1 promoter, our understanding of the mouse H1 promoter remains limited.
Jiaying Wu, Yufei Zhou, Di Zhao, Ran Xu, Jienan Wang, Hong Lin, Zhiwen Ding, Yunzeng Zou   +7 more
doaj   +2 more sources

Role of RNA polymerase III transcription and regulation in ischaemic stroke [PDF]

RNA Biology
Ischaemic stroke is a leading cause of death and life-long disability due to neuronal cell death resulting from interruption of glucose and oxygen supplies.
Chi Kwan Tsang, X.F. Steven Zheng
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Single-cell RNA sequencing of nc886, a non-coding RNA transcribed by RNA polymerase III, with a primer spike-in strategy. [PDF]

PLoS ONE
Single-cell RNA sequencing (scRNA-seq) has emerged as a versatile tool in biology, enabling comprehensive genomic-level characterization of individual cells. Currently, most scRNA-seq methods generate barcoded cDNAs by capturing the polyA tails of mRNAs,
Gyeong-Jin Shin, Byung-Han Choi, Hye Hyeon Eum, Areum Jo, Nayoung Kim, Huiram Kang, Dongwan Hong, Jiyoung Joan Jang, Hwi-Ho Lee, Yeon-Su Lee, Yong Sun Lee, Hae-Ock Lee   +11 more
doaj   +3 more sources