Results 1 to 10 of about 331,347 (206)

RNA Polymerase III Regulates HIV Replication and Latency [PDF]

Viruses
The elimination of HIV latent reservoirs is an extremely challenging task due to the interplay of multiple mechanisms regulating latency. Thus, we need to identify novel strategies to target heterogeneous reservoirs uniformly.
Landon Thompson, Imran Jamal, Juthika Das, Casey Dang, Zhenzi Hong, Doran Katz, Alberto Bosque, Vir B. Singh   +7 more
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RNA Polymerase III, Ageing and Longevity [PDF]

Frontiers in Genetics, 2021
Transcription in eukaryotic cells is performed by three RNA polymerases. RNA polymerase I synthesises most rRNAs, whilst RNA polymerase II transcribes all mRNAs and many non-coding RNAs. The largest of the three polymerases is RNA polymerase III (Pol III)
Yavuz Kulaberoglu, Yasir Malik, Gillian Borland, Colin Selman, Nazif Alic, Jennifer M. A. Tullet   +5 more
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Computationally derived RNA polymerase III promoters enable maize genome editing [PDF]

Frontiers in Plant Science
CRISPR endonucleases require cognate non-coding RNA species for site-specific activity. These RNA species are typically expressed using endogenous RNA polymerase III (Pol III) promoters compatible with the host species.
Ervin D. Nagy, Ian W. Davis, Shanshan Song, Valerie No, Chenxi Wu, Lisa Kanizay, Sarah Turner-Hissong, Hong Li, Xudong Ye, Jeffrey C. Berry, Brandi Chiapelli, Jennifer P. C. To, Matthew S. Marengo   +12 more
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Analysis of RNA Transcribed by RNA Polymerase III from B2 SINEs in Mouse Cells [PDF]

Non-Coding RNA
Background/Objectives: SINEs (short interspersed elements) are eukaryotic non-autonomous retrotransposons. They are transcribed by RNA polymerase III (pol III) and generate non-coding RNAs.
Olga R. Borodulina, Sergey A. Kosushkin, Ilia G. Ustyantsev, Nikita S. Vassetzky, Dmitri A. Kramerov   +4 more
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Decreased RNA polymerase III subunit expression leads to defects in oligodendrocyte development [PDF]

Frontiers in Neuroscience, 2023
IntroductionRNA polymerase III (Pol III) is a critical enzymatic complex tasked with the transcription of ubiquitous non-coding RNAs including 5S rRNA and all tRNA genes.
Julia Macintosh, Julia Macintosh, Mackenzie Michell-Robinson, Mackenzie Michell-Robinson, Xiaoru Chen, Xiaoru Chen, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard   +10 more
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RNA polymerase III is involved in regulating Plasmodium falciparum virulence [PDF]

eLife
While often undetected and untreated, persistent seasonal asymptomatic malaria infections remain a global public health problem. Despite the presence of parasites in the peripheral blood, no symptoms develop.
Gretchen Diffendall, Aurelie Claes, Anna Barcons-Simon, Prince Nyarko, Florent Dingli, Miguel M Santos, Damarys Loew, Antoine Claessens, Artur Scherf   +8 more
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Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing [PDF]

Nature Communications
RNA polymerase III (Pol III) transcribes cytosolic transfer RNAs (tRNAs) and other non-coding RNAs (ncRNAs) essential to cellular function. However, many aspects of Pol III transcription and processing, including RNA modifications, remain poorly ...
Ruth Verstraten, Pierina Cetraro, Amy H. Fitzpatrick, Yasmine Alwie, Yannick N. Frommeyer, Elene Loliashvili, Saskia C. Stein, Susanne Häussler, Werner J. D. Ouwendijk, Daniel P. Depledge   +9 more
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Role of RNA polymerase III transcription and regulation in ischaemic stroke [PDF]

RNA Biology
Ischaemic stroke is a leading cause of death and life-long disability due to neuronal cell death resulting from interruption of glucose and oxygen supplies.
Chi Kwan Tsang, X.F. Steven Zheng
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Engineered mouse H1 promoter mutants with superior RNA polymerase III activity [PDF]

Biochemistry and Biophysics Reports
Vectors incorporating the human H1 (hH1) promoter are being applied for RNA interference (RNAi) experiments and genome editing. Although extensive studies have been conducted on the hH1 promoter, our understanding of the mouse H1 promoter remains limited.
Jiaying Wu, Yufei Zhou, Di Zhao, Ran Xu, Jienan Wang, Hong Lin, Zhiwen Ding, Yunzeng Zou   +7 more
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STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis [PDF]

eLife, 2023
Deregulation of Pol III products causes a range of diseases, including neural diseases and cancers. However, the factors and mechanisms that modulate Pol III-directed transcription remain to be found, although massive advances have been achieved.
Cheng Zhang, Shasha Zhao, Huan Deng, Shihua Zhang, Juan Wang, Xiaoye Song, Deen Yu, Yue Zhang, Wensheng Deng   +8 more
doaj   +2 more sources