MAF1 is a predictive biomarker in HER2 positive breast cancer. [PDF]
PLoS ONE, 2023 RNA polymerase III transcription is pivotal in regulating cellular growth and frequently deregulated in various cancers. MAF1 negatively regulates RNA polymerase III transcription.
Stephanie Cabarcas-Petroski +2 more
doaj +5 more sources
MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment [PDF]
Journal for ImmunoTherapy of CancerBackground The biological significance of MAF1, a tumor suppressor, in carcinogenesis and immune response of hepatocellular carcinoma (HCC) remains unreported.
Di Cao +9 more
doaj +6 more sources
Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation [PDF]
Cell Reports, 2018 Summary: RNA polymerase (pol) III transcribes a variety of small untranslated RNAs involved in transcription, RNA processing, and translation. RNA pol III and its components are altered in various human developmental disorders, yet their roles in cell ...
Wange Lu +2 more
exaly +6 more sources
MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass [PDF]
eLife, 2022 MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1
Ellen Phillips +10 more
doaj +7 more sources
Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse [PDF]
Frontiers in Molecular Biosciences, 2023 MAF1 is a nutrient-sensitive, TORC1-regulated repressor of RNA polymerase III (Pol III). MAF1 downregulation leads to increased lipogenesis in Drosophila melanogaster, Caenorhabditis elegans, and mice.
Gilles Willemin +8 more
doaj +3 more sources
Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer’s disease [PDF]
BrainAbstract Alzheimer’s disease is neurodegenerative and characterized by progressive cognitive impairment. Synaptic dysfunction appears in the early stage of Alzheimer’s disease and is significantly correlated with cognitive impairment. However, the specific regulatory mechanism remains unclear.
Hongxiang Yu
exaly +4 more sources
Journal of Advanced Research, 2023 Introduction: Spontaneous recovery after CNS injury is often very limited and incomplete, leaving most stroke patients with permanent disability. Maf1 is known as a key growth suppressor in proliferating cells.
Chi Kwan Tsang +2 more
exaly +3 more sources
Maf1 phenotypes and cell physiology [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2018 As a master regulator of transcription by RNA polymerase (Pol) III, Maf1 represses the synthesis of highly abundant non-coding RNAs as anabolic signals dissipate, as the quality or quantity of nutrients decreases, and under a wide range of cellular and environmental stress conditions.
Ian Willis
exaly +3 more sources
Genome-Wide Association Analysis of Hippocampal Neuroplasticity as an Indicator of Stress Responsiveness in Laying Hens (Gallus gallus domesticus). [PDF]
Anim GenetABSTRACT Environmental stressors in commercial poultry systems can negatively affect bird welfare, although individuals vary considerably in their responses. Neuroplasticity within the hippocampus, measured through the density of doublecortin‐positive (DCX+) neurons, provides a potential biomarker of stress experience in laying hens.
Neuert L +8 more
europepmc +2 more sources
MAF1 sequesters mitochondria for Toxoplasma gondii. [PDF]
PLoS Biology, 2014 Mitochondria, the powerhouses of eukaryotic cells, regulate many pathways related to cell growth and division. They also participate in apoptotic cell death and survival pathways such as autophagy and in innate immune responses. As such, mitochondria are a tempting target for intracellular pathogens, which may seek to block or manipulate mitochondrial ...
Caitlin Sedwick
doaj +4 more sources