MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment [PDF]
Journal for ImmunoTherapy of CancerBackground The biological significance of MAF1, a tumor suppressor, in carcinogenesis and immune response of hepatocellular carcinoma (HCC) remains unreported.
Di Cao +9 more
doaj +4 more sources
MAF1 is a predictive biomarker in HER2 positive breast cancer. [PDF]
PLoS ONE, 2023 RNA polymerase III transcription is pivotal in regulating cellular growth and frequently deregulated in various cancers. MAF1 negatively regulates RNA polymerase III transcription.
Stephanie Cabarcas-Petroski +2 more
doaj +4 more sources
Journal of Advanced Research, 2023 Introduction: Spontaneous recovery after CNS injury is often very limited and incomplete, leaving most stroke patients with permanent disability. Maf1 is known as a key growth suppressor in proliferating cells.
Chi Kwan Tsang +2 more
exaly +3 more sources
Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse [PDF]
Frontiers in Molecular Biosciences, 2023 MAF1 is a nutrient-sensitive, TORC1-regulated repressor of RNA polymerase III (Pol III). MAF1 downregulation leads to increased lipogenesis in Drosophila melanogaster, Caenorhabditis elegans, and mice.
Gilles Willemin +8 more
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Aurora-A-mediated cytosolic localization of Maf1 promotes cell proliferation via regulating mitochondrial function in HCC [PDF]
Cell Death DiscoveryMaf1 is a well-known RNA polymerase III repressor and functions as a tumor suppressor due to its role in inhibiting tRNA synthesis. However, the role of Maf1 in hepatocellular carcinoma (HCC) remains unclear.
Shiang-Jie Yang +9 more
doaj +2 more sources
Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms [PDF]
iScience, 2023 Summary: The generation of appropriate numbers and types of neurons is a prerequisite for assembling functional neural circuits. However, the molecular basis regulating retinal neuron number remains poorly understood. Here, we report that inactivation of
Yifei Li +4 more
doaj +2 more sources
Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy [PDF]
Cellular & Molecular Biology LettersBackground A previous study found that MAF1 homolog, a negative regulator of RNA polymerase III (MAF1), protects the blood–brain barrier (BBB) in sepsis-associated encephalopathy (SAE); however, the related molecular mechanisms remain unclear.
Xuebiao Wei +7 more
doaj +2 more sources
Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation. [PDF]
PLoS BiologyAttenuating protein synthesis promotes longevity in multiple species. However, numerous studies indicate that aging drives a decrease in protein synthetic capacity.
Bowen Xu +6 more
doaj +2 more sources
SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice [PDF]
Nature CommunicationsNerve injury-induced changes in pain-associated genes contribute to genesis of neuropathic pain and comorbid anxiety. Phosphorylated CTD interacting factor-1 (PCIF1)-triggered N6, 2′-O-dimethyladenosine (m6Am) mRNA modification represents an additional ...
Yue Huang +17 more
doaj +2 more sources
Insulin resistance and exercise-induced insulin sensitization in skeletal muscle: Insights from personalized phosphoproteomics. [PDF]
J Diabetes InvestigInsulin resistance in muscle mainly disrupts non‐canonical insulin signaling pathways. Exercise‐induced MINDY1 S441 phosphorylation improves insulin sensitivity, highlighting its potential role in mediating exercise benefits in metabolic disease.
Masuda S, Matsuzaka T.
europepmc +2 more sources