Journal of Advanced Research, 2023 Introduction: Spontaneous recovery after CNS injury is often very limited and incomplete, leaving most stroke patients with permanent disability. Maf1 is known as a key growth suppressor in proliferating cells.
Chi Kwan Tsang +2 more
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Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse [PDF]
Frontiers in Molecular Biosciences, 2023 MAF1 is a nutrient-sensitive, TORC1-regulated repressor of RNA polymerase III (Pol III). MAF1 downregulation leads to increased lipogenesis in Drosophila melanogaster, Caenorhabditis elegans, and mice.
Gilles Willemin +8 more
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MAF1 inhibits hepatocarcinogenesis by fostering an immunostimulatory tumor microenvironment [PDF]
Journal for ImmunoTherapy of CancerBackground The biological significance of MAF1, a tumor suppressor, in carcinogenesis and immune response of hepatocellular carcinoma (HCC) remains unreported.
Di Cao +9 more
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MAF1 is a predictive biomarker in HER2 positive breast cancer. [PDF]
PLoS ONE, 2023 RNA polymerase III transcription is pivotal in regulating cellular growth and frequently deregulated in various cancers. MAF1 negatively regulates RNA polymerase III transcription.
Stephanie Cabarcas-Petroski +2 more
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Aurora-A-mediated cytosolic localization of Maf1 promotes cell proliferation via regulating mitochondrial function in HCC [PDF]
Cell Death DiscoveryMaf1 is a well-known RNA polymerase III repressor and functions as a tumor suppressor due to its role in inhibiting tRNA synthesis. However, the role of Maf1 in hepatocellular carcinoma (HCC) remains unclear.
Shiang-Jie Yang +9 more
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Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms [PDF]
iScience, 2023 Summary: The generation of appropriate numbers and types of neurons is a prerequisite for assembling functional neural circuits. However, the molecular basis regulating retinal neuron number remains poorly understood. Here, we report that inactivation of
Yifei Li +4 more
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Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy [PDF]
Cellular & Molecular Biology LettersBackground A previous study found that MAF1 homolog, a negative regulator of RNA polymerase III (MAF1), protects the blood–brain barrier (BBB) in sepsis-associated encephalopathy (SAE); however, the related molecular mechanisms remain unclear.
Xuebiao Wei +7 more
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Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation. [PDF]
PLoS BiologyAttenuating protein synthesis promotes longevity in multiple species. However, numerous studies indicate that aging drives a decrease in protein synthetic capacity.
Bowen Xu +6 more
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SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice [PDF]
Nature CommunicationsNerve injury-induced changes in pain-associated genes contribute to genesis of neuropathic pain and comorbid anxiety. Phosphorylated CTD interacting factor-1 (PCIF1)-triggered N6, 2′-O-dimethyladenosine (m6Am) mRNA modification represents an additional ...
Yue Huang +17 more
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Frontiers in Immunology, 2020 BackgroundThe NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been identified as an important mediator of blood–brain-barrier disruption in sepsis-associated encephalopathy (SAE).
Wenqiang Jiang +2 more
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