Results 31 to 40 of about 1,609 (154)

Structural basis of RNA polymerase III transcription repression by Maf1 [PDF]

Nature Structural & Molecular Biology, 2019
ABSTRACT Maf1 is a highly conserved central regulator of transcription by RNA polymerase III (Pol III), and Maf1 activity influences a wide range of phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, which establishes how Maf1 achieves transcription repression. In
Vorländer, Matthias K., Baudin, Florence, Moir, Robyn D., Wetzel, René, Hagen, Wim J. H., Willis, Ian M., Müller, Christoph W.   +6 more
openaire   +3 more sources

Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes. [PDF]

PLoS Genetics, 2008
Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and stress signaling pathways on Maf1,
Ian M Willis, Gordon Chua, Amy H Tong, Renee L Brost, Timothy R Hughes, Charles Boone, Robyn D Moir   +6 more
doaj   +1 more source

ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1

Experimental and Therapeutic Medicine, 2021
The protection of brain tissue against damage and the reduction of infarct size is crucial for improving patient prognosis following ischemic stroke. Therefore, the present study aimed to investigate the regulatory effect of microRNA (miR)-122 and its target gene repressor of RNA polymerase III transcription MAF1 homolog (Maf1) on the infarct area in ...
Mengmeng, Wang, Xiaoman, Liu, Yu, Wu, Yi, Wang, Jiahui, Cui, Jing, Sun, Ying, Bai, Ming-Fei, Lang   +7 more
openaire   +3 more sources

Generation of two iPSC lines from healthy donor with a heterozygous mutation in the VPS13B gene

Stem Cell Research, 2022
The human induced pluripotent stem cell (iPSC) lines, iCS-MAF1-1 and iCS-MAF1-11, were generated from fibroblasts. The donor has a heterozygous mutation in the VPS13B gene, which manifests in her child as Cohen syndrome.
S.A. Chechetkina, A.A. Khabarova, A.S. Chvileva, O.M. Kurchenko, A.V. Smirnov, A.M. Yunusova, I.N. Kotov, E.V. Musatova, E.A. Pomerantseva, E.A. Volovikov, M.A. Lagarkova, T.A. Shnaider, I.E. Pristyazhnyuk   +12 more
doaj   +1 more source

MAF1 is a chronic repressor of RNA polymerase III transcription in the mouse [PDF]

Scientific Reports, 2019
Abstract Maf1 −/− mice are lean, obesity-resistant and metabolically inefficient. Their increased energy expenditure is thought to be driven by a futile RNA cycle that reprograms metabolism to meet an increased demand for ...
Bonhoure, Nicolas, Praz, Viviane, Moir, Robyn D., Willemin, Gilles, Mange, François, Moret, Catherine, Willis, Ian M., Hernandez, Nouria   +7 more
openaire   +4 more sources

Maf1 cooperates with progesterone receptor to repress RNA polymerase III transcription of select tRNAs. [PDF]

Nucleic Acids Res
Abstract Progesterone receptors (PRs) can regulate transcription by RNA polymerase III (Pol III), which transcribes small non-coding RNAs, including all transfer RNAs (tRNAs). We previously demonstrated that PR is associated with the Pol III complex at tRNA genes and that progestins downregulate tRNA transcripts in breast tumor models.
Finlay-Schultz J, Vinod Paul K, Erickson B, Fettig LM, Hastings BS, Johnson DL, Bentley DL, Kabos P, Sartorius CA.   +8 more
europepmc   +5 more sources

MoMaf1 Mediates Vegetative Growth, Conidiogenesis, and Pathogenicity in the Rice Blast Fungus Magnaporthe oryzae

Journal of Fungi, 2023
In eukaryotes, Maf1 is an essential and specific negative regulator of RNA polymerase (Pol) III. Pol III, which synthesizes 5S RNA and transfer RNAs (tRNAs), is suppressed by Maf1 under the conditions of nutrient starvation or environmental stress. Here,
Bin Qian, Lingyuan Guo, Chi Song, Hong Ji   +3 more
doaj   +1 more source

Maf1, A New PTEN Target Linking RNA and Lipid Metabolism [PDF]

Trends in Endocrinology & Metabolism, 2016
PTEN is a critical tumor suppressor whose dysregulation leads to metabolic disease and cancer. How these diseases are linked at a molecular level is poorly understood. Maf1 is a novel PTEN target that connects PTEN's ability to repress intracellular lipid accumulation with its tumor suppressor function.
Deborah L, Johnson, Bangyan L, Stiles
openaire   +2 more sources

Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity [PDF]

Journal of Molecular Biology, 2015
Maf1 was first identified in yeast, and studies in metazoans have primarily focused on examining its role in the repression of transcription that is dependent on RNA polymerase III. Recent work has revealed a novel and conserved function for Maf1 in the maintenance of intracellular lipid pools in Caenorhabditis elegans, mice, and cancer cell lines ...
Akshat, Khanna, Ajay, Pradhan, Sean P, Curran   +2 more
openaire   +2 more sources

The Mitogen-Activated Protein Kinase Gene MAF1 Is Essential for the Early Differentiation Phase of Appressorium Formation in Colletotrichum lagenarium

Molecular Plant-Microbe Interactions, 2002
Colletotrichum lagenarium, the causal agent of cucumber anthracnose, invades host plants by forming a specialized infection structure called an appressorium.
Kaihei Kojima, Taisei Kikuchi, Yoshitaka Takano, Eriko Oshiro, Tetsuro Okuno   +4 more
doaj   +1 more source