Results 31 to 40 of about 1,593 (136)

Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes. [PDF]

PLoS Genetics, 2008
Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and stress signaling pathways on Maf1,
Ian M Willis, Gordon Chua, Amy H Tong, Renee L Brost, Timothy R Hughes, Charles Boone, Robyn D Moir   +6 more
doaj   +1 more source

Maf1 cooperates with progesterone receptor to repress RNA polymerase III transcription of select tRNAs. [PDF]

Nucleic Acids Res
Abstract Progesterone receptors (PRs) can regulate transcription by RNA polymerase III (Pol III), which transcribes small non-coding RNAs, including all transfer RNAs (tRNAs). We previously demonstrated that PR is associated with the Pol III complex at tRNA genes and that progestins downregulate tRNA transcripts in breast tumor models.
Finlay-Schultz J, Vinod Paul K, Erickson B, Fettig LM, Hastings BS, Johnson DL, Bentley DL, Kabos P, Sartorius CA.   +8 more
europepmc   +5 more sources

Generation of two iPSC lines from healthy donor with a heterozygous mutation in the VPS13B gene

Stem Cell Research, 2022
The human induced pluripotent stem cell (iPSC) lines, iCS-MAF1-1 and iCS-MAF1-11, were generated from fibroblasts. The donor has a heterozygous mutation in the VPS13B gene, which manifests in her child as Cohen syndrome.
S.A. Chechetkina, A.A. Khabarova, A.S. Chvileva, O.M. Kurchenko, A.V. Smirnov, A.M. Yunusova, I.N. Kotov, E.V. Musatova, E.A. Pomerantseva, E.A. Volovikov, M.A. Lagarkova, T.A. Shnaider, I.E. Pristyazhnyuk   +12 more
doaj   +1 more source

Structural basis of RNA polymerase III transcription repression by Maf1 [PDF]

Nature Structural & Molecular Biology, 2019
ABSTRACT Maf1 is a highly conserved central regulator of transcription by RNA polymerase III (Pol III), and Maf1 activity influences a wide range of phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, which establishes how Maf1 achieves transcription repression. In
Vorländer, Matthias K., Baudin, Florence, Moir, Robyn D., Wetzel, René, Hagen, Wim J. H., Willis, Ian M., Müller, Christoph W.   +6 more
openaire   +3 more sources

MoMaf1 Mediates Vegetative Growth, Conidiogenesis, and Pathogenicity in the Rice Blast Fungus Magnaporthe oryzae

Journal of Fungi, 2023
In eukaryotes, Maf1 is an essential and specific negative regulator of RNA polymerase (Pol) III. Pol III, which synthesizes 5S RNA and transfer RNAs (tRNAs), is suppressed by Maf1 under the conditions of nutrient starvation or environmental stress. Here,
Bin Qian, Lingyuan Guo, Chi Song, Hong Ji   +3 more
doaj   +1 more source

Maf1, A New PTEN Target Linking RNA and Lipid Metabolism [PDF]

Trends in Endocrinology & Metabolism, 2016
PTEN is a critical tumor suppressor whose dysregulation leads to metabolic disease and cancer. How these diseases are linked at a molecular level is poorly understood. Maf1 is a novel PTEN target that connects PTEN's ability to repress intracellular lipid accumulation with its tumor suppressor function.
Deborah L, Johnson, Bangyan L, Stiles
openaire   +2 more sources

The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability [PDF]

Journal of Molecular Biology, 2017
MAF1 is a conserved negative regulator of RNA polymerase (pol) III and intracellular lipid homeostasis across species. Here, we show that the MAF1 C-box region negatively regulates its activity. Mutations in Caenorhabditis elegans mafr-1 that truncate the C-box retain the ability to inhibit the transcription of RNA pol III targets, reduce lipid ...
Ajay, Pradhan, Amy M, Hammerquist, Akshat, Khanna, Sean P, Curran   +3 more
openaire   +2 more sources

The Mitogen-Activated Protein Kinase Gene MAF1 Is Essential for the Early Differentiation Phase of Appressorium Formation in Colletotrichum lagenarium

Molecular Plant-Microbe Interactions, 2002
Colletotrichum lagenarium, the causal agent of cucumber anthracnose, invades host plants by forming a specialized infection structure called an appressorium.
Kaihei Kojima, Taisei Kikuchi, Yoshitaka Takano, Eriko Oshiro, Tetsuro Okuno   +4 more
doaj   +1 more source

ECONOMIC POTENTIAL FOR PROMOTION OF EGYPTIAN ONIONS EXPORTS [PDF]

Journal of Agricultural Economics and Social Sciences, 2003
Through study of major maf1(ets of Egyptian onions exports and the prevalent innuential factors, promotion potentials were investigated. The studY~Showed winter onions as the principal onions exports of which the Arab Gulf Cooperati n bloc Imports shar~
Laila EL-shraif,
doaj   +1 more source

Maf1 Is Involved in Coupling Carbon Metabolism to RNA Polymerase III Transcription [PDF]

Molecular and Cellular Biology, 2007
RNA polymerase III (Pol III) produces essential components of the biosynthetic machinery, and therefore its activity is tightly coupled with cell growth and metabolism. In the yeast Saccharomyces cerevisiae, Maf1 is the only known global and direct Pol III transcription repressor which mediates numerous stress signals.
Małgorzata, Cieśla, Joanna, Towpik, Damian, Graczyk, Danuta, Oficjalska-Pham, Olivier, Harismendy, Audrey, Suleau, Karol, Balicki, Christine, Conesa, Olivier, Lefebvre, Magdalena, Boguta   +9 more
openaire   +2 more sources