Results 31 to 40 of about 2,035 (177)

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance [PDF]

Genes & Development, 2015
MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy. Here we show that a whole-body knockout of Maf1
Bonhoure Nicolas, Byrnes Ashlee, Moir Robyn D., Hodroj Wassim, Preitner Frédéric, Praz Viviane, Marcelin Genevieve, Chua Streamson C., Martinez-Lopez Nuria, Singh Rajat, Moullan, Norman, Auwerx Johan, Willemin Gilles, Shah Hardik, Hartil Kirsten, Vaitheesvaran Bhavapriya, Kurland Irwin, Hernandez Nouria, Willis Ian M.   +19 more
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Plasmodium falciparum Maf1 Confers Survival upon Amino Acid Starvation

mBio, 2017
The target of rapamycin complex 1 (TORC1) pathway is a highly conserved signaling pathway across eukaryotes that integrates nutrient and stress signals to regulate the cellular growth rate and the transition into and maintenance of dormancy. The majority
Kyle Jarrod McLean, Marcelo Jacobs-Lorena   +1 more
doaj   +3 more sources

Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons [PDF]

Molecular and Cellular Neuroscience, 2010
The majority of fast inhibitory synaptic transmission in the mammalian nervous system is mediated by GABA(A) receptors (GABA(A)Rs). Here we report a novel interaction between the protein Maf1 and GABA(A)R beta-subunit intracellular domains. We find Maf1 to be highly expressed in brain and enriched in the hippocampus and cortex.
Smith, K, Oliver, P, Lumb, M, Arancibia-Carcamo, I, Revilla-Sanchez, R, Brandon, N, Moss, S, Kittler, J   +7 more
openaire   +3 more sources

Role of RNA polymerase III transcription and regulation in ischaemic stroke [PDF]

RNA Biology
Ischaemic stroke is a leading cause of death and life-long disability due to neuronal cell death resulting from interruption of glucose and oxygen supplies.
Chi Kwan Tsang, X.F. Steven Zheng
doaj   +2 more sources

RNA polymerase III is involved in regulating Plasmodium falciparum virulence [PDF]

eLife
While often undetected and untreated, persistent seasonal asymptomatic malaria infections remain a global public health problem. Despite the presence of parasites in the peripheral blood, no symptoms develop.
Gretchen Diffendall, Aurelie Claes, Anna Barcons-Simon, Prince Nyarko, Florent Dingli, Miguel M Santos, Damarys Loew, Antoine Claessens, Artur Scherf   +8 more
doaj   +2 more sources

The MAF1 Phosphoregulatory Region Controls MAF1 Interaction with the RNA Polymerase III C34 Subunit and Transcriptional Repression in Plants [PDF]

The Plant Cell, 2020
MAF1 is a phosphoprotein that plays a critical role in cell growth control as the central regulator of RNA polymerase (Pol) III activity. Citrus MAF1 (CsMAF1) was identified as a direct target of PthA4, a bacterial effector protein required to induce tumors in citrus.
Maxuel Oliveira Andrade, Mauricio Luis Sforça, Fernanda Aparecida Heleno Batista, Ana Carolina Migliorini Figueira, Celso Eduardo Benedetti   +4 more
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Maf1 regulates dendritic morphogenesis and influences learning and memory [PDF]

Cell Death & Disease, 2020
Abstract Maf1, a general transcriptional regulator and mTOR downstream effector, is highly expressed in the hippocampus and cortex, but the function of Maf1 in neurons is not well elucidated. Here, we first demonstrate that Maf1 plays a central role in the inhibition of dendritic morphogenesis and the growth of dendritic spines both in vitro ...
Kui Chen, Liang Zhu, Lin Guo, Yuan-Bo Pan, Dong-Fu Feng   +4 more
openaire   +2 more sources

Maf1 regulation: A model of signal transduction inside the nucleus [PDF]

Nucleus, 2010
RNA polymerase III (Pol III) is responsible for the synthesis of 5S ribosomal RNA (rRNA) and transfer RNAs (tRNAs) essential for protein synthesis and cell growth. Pol III is tightly controlled by growth signals such as nutrients and deregulation of Pol III-dependent transcription can lead to oncogenic transformation.
Yuehua, Wei, Xf Steven, Zheng
openaire   +3 more sources

mTORC1 Directly Phosphorylates and Regulates Human MAF1 [PDF]

Molecular and Cellular Biology, 2010
mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets have been identified. RNA polymerase (pol) III produces a number of essential RNA molecules involved in protein synthesis, RNA maturation, and other processes. Its activity is highly regulated, and deregulation can lead to cell transformation. The human
Michels, A. A., Robitaille, A. M., Buczynski-Ruchonnet, D., Hodroj, W., Reina, J. H., Hall, M. N., Hernandez, N.   +6 more
openaire   +6 more sources

Maf1 regulates intracellular lipid homeostasis in response to DDR activation [PDF]

Molecular Biology of the Cell, 2021
Surveillance of DNA damage and maintenance of lipid metabolism are critical factors for general cellular homeostasis. We discovered that in response to DNA damage-inducing UV light exposure, intact C. elegans accumulate intracellular lipids in a dose dependent manner.
Amy M. Hammerquist, Wilber Escorcia, Sean P. Curran   +2 more
openaire   +2 more sources