Results 11 to 20 of about 2,035 (177)

Maf1, a general negative regulator of RNA polymerase III in yeast [PDF]

Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2013
tRNA synthesis by yeast RNA polymerase III (Pol III) is down-regulated under growth-limiting conditions. This control is mediated by Maf1, a global negative regulator of Pol III transcription. Conserved from yeast to man, Maf1 was originally discovered in Saccharomyces cerevisiae by a genetic approach.
Magdalena Rakowska-Boguta
exaly   +6 more sources

Maf1, a new player in the regulation of human RNA polymerase III transcription. [PDF]

PLoS ONE, 2006
Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumor suppressors P53 and Rb, and the proto-oncogene c-Myc.
Jaime H Reina, Teldja N Azzouz, Nouria Hernandez   +2 more
doaj   +7 more sources

Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy [PDF]

Cellular & Molecular Biology Letters
Background A previous study found that MAF1 homolog, a negative regulator of RNA polymerase III (MAF1), protects the blood–brain barrier (BBB) in sepsis-associated encephalopathy (SAE); however, the related molecular mechanisms remain unclear.
Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen   +7 more
doaj   +3 more sources

Molecular Basis of RNA Polymerase III Transcription Repression by Maf1 [PDF]

Cell, 2010
RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress conditions, the conserved protein Maf1 rapidly represses Pol III transcription. We report the crystal structure of Maf1 and cryo-electron microscopic structures of Pol III, an active Pol III-DNA-RNA complex, and a repressive Pol III-Maf1 complex.
Vannini, Alessandro, Ringel, Rieke, Kusser, Anselm G., Berninghausen, Otto, Kassavetis, George A., Cramer, Patrick   +5 more
openaire   +6 more sources

Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. [PDF]

PLoS Genetics, 2014
Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes, yet little is known about its other potential target genes or its biological function.
Beth M Palian, Aarti D Rohira, Sandra A S Johnson, Lina He, Ni Zheng, Louis Dubeau, Bangyan L Stiles, Deborah L Johnson   +7 more
doaj   +2 more sources

Aurora-A-mediated cytosolic localization of Maf1 promotes cell proliferation via regulating mitochondrial function in HCC [PDF]

Cell Death Discovery
Maf1 is a well-known RNA polymerase III repressor and functions as a tumor suppressor due to its role in inhibiting tRNA synthesis. However, the role of Maf1 in hepatocellular carcinoma (HCC) remains unclear.
Shiang-Jie Yang, Yu-Heng Kuan, Zong-Xin Ooi, Hong-Sheng Lai, Hsin-Yi Wu, Pao-Chi Liao, Yih-Jyh Lin, Che Min Su, Ming-Derg Lai, Liang-Yi Hung   +9 more
doaj   +2 more sources

Maf1 controls retinal neuron number by both RNA Pol III- and Pol II-dependent mechanisms [PDF]

iScience, 2023
Summary: The generation of appropriate numbers and types of neurons is a prerequisite for assembling functional neural circuits. However, the molecular basis regulating retinal neuron number remains poorly understood. Here, we report that inactivation of
Yifei Li, Dongchang Xiao, Haiqiao Chen, X.F. Steven Zheng, Mengqing Xiang   +4 more
doaj   +2 more sources

Regulating maf1 expression and its expanding biological functions. [PDF]

PLoS Genetics, 2015
Maf1 is a nutrient- and stress-sensitive global repressor of transcription by RNA polymerase (pol) III [1], [2]. Its primary function in this context is to limit the synthesis of highly abundant 5S rRNA and tRNAs in response to nutrient availability and cellular stress [3]. Thus, Maf1 ensures the efficient use of metabolic resources while balancing the
Robyn D Moir, Ian M Willis
doaj   +4 more sources

Loss of Pol III repressor Maf1 in neurons promotes longevity by preventing the age-related decline in 5S rRNA and translation. [PDF]

PLoS Biology
Attenuating protein synthesis promotes longevity in multiple species. However, numerous studies indicate that aging drives a decrease in protein synthetic capacity.
Bowen Xu, Alexander Hull, Olivia N M Hill, Naja Kobal, Enric Ureña, Linda Partridge, Nazif Alic   +6 more
doaj   +2 more sources

Differential regulation of ribogenesis genes throughout oogenesis in thicklip grey mullets, Chelon labrosus, preparing the maternal contribution to embryo development. [PDF]

PLoS ONE
Oocytes in teleosts undergo complex changes during oogenesis, including the accumulation of ribosomal RNAs and tRNAs needed to support protein synthesis during early embryogenesis.
Joyanta Bir, Oihane Diaz de Cerio, Maren Ortiz-Zarragoitia, Ibon Cancio   +3 more
doaj   +2 more sources