Results 11 to 20 of about 1,609 (154)
Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation [PDF]
Cell Reports, 2018 Summary: RNA polymerase (pol) III transcribes a variety of small untranslated RNAs involved in transcription, RNA processing, and translation. RNA pol III and its components are altered in various human developmental disorders, yet their roles in cell ...
Rainer B Lanz +2 more
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Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer’s disease [PDF]
BrainAbstract Alzheimer’s disease is neurodegenerative and characterized by progressive cognitive impairment. Synaptic dysfunction appears in the early stage of Alzheimer’s disease and is significantly correlated with cognitive impairment. However, the specific regulatory mechanism remains unclear.
, Hongxiang Yu, Hongxia Li
exaly +4 more sources
MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass [PDF]
eLife, 2022 MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1
Ellen Phillips +10 more
doaj +4 more sources
Maf1, a new player in the regulation of human RNA polymerase III transcription. [PDF]
PLoS ONE, 2006 Human RNA polymerase III (pol III) transcription is regulated by several factors, including the tumor suppressors P53 and Rb, and the proto-oncogene c-Myc.
Jaime H Reina +2 more
doaj +6 more sources
MAF1 represses CDKN1A through a Pol III-dependent mechanism
eLife, 2015 MAF1 represses Pol III-mediated transcription by interfering with TFIIIB and Pol III. Herein, we found that MAF1 knockdown induced CDKN1A transcription and chromatin looping concurrently with Pol III recruitment.
Yu-Ling Lee +5 more
doaj +3 more sources
Frontiers in Immunology, 2020 BackgroundThe NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been identified as an important mediator of blood–brain-barrier disruption in sepsis-associated encephalopathy (SAE).
Chaogang Tang +2 more
exaly +3 more sources
Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response.
PLoS Biology, 2014 Recent information has revealed the functional diversity and importance of mitochondria in many cellular processes including orchestrating the innate immune response. Intriguingly, several infectious agents, such as Toxoplasma, Legionella, and Chlamydia,
Lena Pernas +6 more
doaj +4 more sources
mBio, 2017 The target of rapamycin complex 1 (TORC1) pathway is a highly conserved signaling pathway across eukaryotes that integrates nutrient and stress signals to regulate the cellular growth rate and the transition into and maintenance of dormancy. The majority
Kyle Jarrod McLean +1 more
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Role of RNA polymerase III transcription and regulation in ischaemic stroke [PDF]
RNA BiologyIschaemic stroke is a leading cause of death and life-long disability due to neuronal cell death resulting from interruption of glucose and oxygen supplies.
Chi Kwan Tsang, X.F. Steven Zheng
doaj +2 more sources
MAF1 sequesters mitochondria for Toxoplasma gondii. [PDF]
PLoS Biology, 2014 Mitochondria, the powerhouses of eukaryotic cells, regulate many pathways related to cell growth and division. They also participate in apoptotic cell death and survival pathways such as autophagy and in innate immune responses. As such, mitochondria are a tempting target for intracellular pathogens, which may seek to block or manipulate mitochondrial ...
Caitlin Sedwick
doaj +4 more sources