Results 21 to 30 of about 1,609 (154)

RNA polymerase III is involved in regulating Plasmodium falciparum virulence [PDF]

eLife
While often undetected and untreated, persistent seasonal asymptomatic malaria infections remain a global public health problem. Despite the presence of parasites in the peripheral blood, no symptoms develop.
Gretchen Diffendall, Aurelie Claes, Anna Barcons-Simon, Prince Nyarko, Florent Dingli, Miguel M Santos, Damarys Loew, Antoine Claessens, Artur Scherf   +8 more
doaj   +2 more sources

Transcriptome and proteome changes triggered by overexpression of the transcriptional regulator Maf1 in the human pathogen Leishmania major

FASEB Journal
The transcriptome and proteome changes caused by the overexpression of Maf1 in the protozoan parasite Leishmania major suggest the participation of this protein in multiple key biological processes. Abstract Maf1, originally described as a repressor of RNA polymerase III (RNAP III) transcription in yeast, participates in multiple functions across ...
Luis A Rivera-Rivas, Luis E Florencio-Martínez, Gabriela Romero-Meza   +2 more
exaly   +2 more sources

Regulating maf1 expression and its expanding biological functions. [PDF]

PLoS Genetics, 2015
Maf1 is a nutrient- and stress-sensitive global repressor of transcription by RNA polymerase (pol) III [1], [2]. Its primary function in this context is to limit the synthesis of highly abundant 5S rRNA and tRNAs in response to nutrient availability and cellular stress [3]. Thus, Maf1 ensures the efficient use of metabolic resources while balancing the
Robyn D Moir, Ian M Willis
doaj   +4 more sources

The MAF1 Phosphoregulatory Region Controls MAF1 Interaction with the RNA Polymerase III C34 Subunit and Transcriptional Repression in Plants [PDF]

The Plant Cell, 2020
MAF1 is a phosphoprotein that plays a critical role in cell growth control as the central regulator of RNA polymerase (Pol) III activity. Citrus MAF1 (CsMAF1) was identified as a direct target of PthA4, a bacterial effector protein required to induce tumors in citrus.
Maxuel Oliveira Andrade, Mauricio Luis Sforça, Fernanda Aparecida Heleno Batista, Ana Carolina Migliorini Figueira, Celso Eduardo Benedetti   +4 more
openaire   +2 more sources

Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. [PDF]

PLoS Genetics, 2014
Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes, yet little is known about its other potential target genes or its biological function.
Beth M Palian, Aarti D Rohira, Sandra A S Johnson, Lina He, Ni Zheng, Louis Dubeau, Bangyan L Stiles, Deborah L Johnson   +7 more
doaj   +1 more source

Maf1 regulates dendritic morphogenesis and influences learning and memory [PDF]

Cell Death & Disease, 2020
Abstract Maf1, a general transcriptional regulator and mTOR downstream effector, is highly expressed in the hippocampus and cortex, but the function of Maf1 in neurons is not well elucidated. Here, we first demonstrate that Maf1 plays a central role in the inhibition of dendritic morphogenesis and the growth of dendritic spines both in vitro ...
Kui Chen, Liang Zhu, Lin Guo, Yuan-Bo Pan, Dong-Fu Feng   +4 more
openaire   +2 more sources

Maf1 regulation: A model of signal transduction inside the nucleus [PDF]

Nucleus, 2010
RNA polymerase III (Pol III) is responsible for the synthesis of 5S ribosomal RNA (rRNA) and transfer RNAs (tRNAs) essential for protein synthesis and cell growth. Pol III is tightly controlled by growth signals such as nutrients and deregulation of Pol III-dependent transcription can lead to oncogenic transformation.
Yuehua, Wei, Xf Steven, Zheng
openaire   +3 more sources

mTORC1 Directly Phosphorylates and Regulates Human MAF1 [PDF]

Molecular and Cellular Biology, 2010
mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets have been identified. RNA polymerase (pol) III produces a number of essential RNA molecules involved in protein synthesis, RNA maturation, and other processes. Its activity is highly regulated, and deregulation can lead to cell transformation. The human
Michels, A. A., Robitaille, A. M., Buczynski-Ruchonnet, D., Hodroj, W., Reina, J. H., Hall, M. N., Hernandez, N.   +6 more
openaire   +6 more sources

Maf1 regulates intracellular lipid homeostasis in response to DDR activation [PDF]

Molecular Biology of the Cell, 2021
Surveillance of DNA damage and maintenance of lipid metabolism are critical factors for general cellular homeostasis. We discovered that in response to DNA damage-inducing UV light exposure, intact C. elegans accumulate intracellular lipids in a dose dependent manner.
Amy M. Hammerquist, Wilber Escorcia, Sean P. Curran   +2 more
openaire   +2 more sources

Molecular Basis of RNA Polymerase III Transcription Repression by Maf1 [PDF]

Cell, 2010
RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress conditions, the conserved protein Maf1 rapidly represses Pol III transcription. We report the crystal structure of Maf1 and cryo-electron microscopic structures of Pol III, an active Pol III-DNA-RNA complex, and a repressive Pol III-Maf1 complex.
Vannini, A., Ringel, R., Kusser, A., Berninghausen, O., Kassavetis, G., Cramer, P.   +5 more
openaire   +4 more sources