Results 21 to 30 of about 1,593 (136)
Regulating maf1 expression and its expanding biological functions. [PDF]
PLoS Genetics, 2015 Maf1 is a nutrient- and stress-sensitive global repressor of transcription by RNA polymerase (pol) III [1], [2]. Its primary function in this context is to limit the synthesis of highly abundant 5S rRNA and tRNAs in response to nutrient availability and cellular stress [3]. Thus, Maf1 ensures the efficient use of metabolic resources while balancing the
Robyn D Moir, Ian M Willis
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The MAF1 Phosphoregulatory Region Controls MAF1 Interaction with the RNA Polymerase III C34 Subunit and Transcriptional Repression in Plants [PDF]
The Plant Cell, 2020 MAF1 is a phosphoprotein that plays a critical role in cell growth control as the central regulator of RNA polymerase (Pol) III activity. Citrus MAF1 (CsMAF1) was identified as a direct target of PthA4, a bacterial effector protein required to induce tumors in citrus.
Maxuel Oliveira Andrade +4 more
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Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. [PDF]
PLoS Genetics, 2014 Maf1 was initially identified as a transcriptional repressor of RNA pol III-transcribed genes, yet little is known about its other potential target genes or its biological function.
Beth M Palian +7 more
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Maf1 regulates dendritic morphogenesis and influences learning and memory [PDF]
Cell Death & Disease, 2020 Abstract Maf1, a general transcriptional regulator and mTOR downstream effector, is highly expressed in the hippocampus and cortex, but the function of Maf1 in neurons is not well elucidated. Here, we first demonstrate that Maf1 plays a central role in the inhibition of dendritic morphogenesis and the growth of dendritic spines both in vitro ...
Kui Chen +4 more
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Maf1 regulation: A model of signal transduction inside the nucleus [PDF]
Nucleus, 2010 RNA polymerase III (Pol III) is responsible for the synthesis of 5S ribosomal RNA (rRNA) and transfer RNAs (tRNAs) essential for protein synthesis and cell growth. Pol III is tightly controlled by growth signals such as nutrients and deregulation of Pol III-dependent transcription can lead to oncogenic transformation.
Yuehua, Wei, Xf Steven, Zheng
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mTORC1 Directly Phosphorylates and Regulates Human MAF1 [PDF]
Molecular and Cellular Biology, 2010 mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets have been identified. RNA polymerase (pol) III produces a number of essential RNA molecules involved in protein synthesis, RNA maturation, and other processes. Its activity is highly regulated, and deregulation can lead to cell transformation. The human
Michels, A. A. +6 more
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Maf1 regulates intracellular lipid homeostasis in response to DDR activation [PDF]
Molecular Biology of the Cell, 2021 Surveillance of DNA damage and maintenance of lipid metabolism are critical factors for general cellular homeostasis. We discovered that in response to DNA damage-inducing UV light exposure, intact C. elegans accumulate intracellular lipids in a dose dependent manner.
Amy M. Hammerquist +2 more
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MAF1 is a chronic repressor of RNA polymerase III transcription in the mouse [PDF]
Scientific Reports, 2019 Abstract Maf1 −/− mice are lean, obesity-resistant and metabolically inefficient. Their increased energy expenditure is thought to be driven by a futile RNA cycle that reprograms metabolism to meet an increased demand for ...
Bonhoure, Nicolas +7 more
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Molecular Basis of RNA Polymerase III Transcription Repression by Maf1 [PDF]
Cell, 2010 RNA polymerase III (Pol III) transcribes short RNAs required for cell growth. Under stress conditions, the conserved protein Maf1 rapidly represses Pol III transcription. We report the crystal structure of Maf1 and cryo-electron microscopic structures of Pol III, an active Pol III-DNA-RNA complex, and a repressive Pol III-Maf1 complex.
Vannini, Alessandro +5 more
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ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1
Experimental and Therapeutic Medicine, 2021 The protection of brain tissue against damage and the reduction of infarct size is crucial for improving patient prognosis following ischemic stroke. Therefore, the present study aimed to investigate the regulatory effect of microRNA (miR)-122 and its target gene repressor of RNA polymerase III transcription MAF1 homolog (Maf1) on the infarct area in ...
Mengmeng, Wang +7 more
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