SERBP1-PCIF1 complex-controlled m6Am modification in glutamatergic neurons of the primary somatosensory cortex is required for neuropathic pain in mice [PDF]
Nature CommunicationsNerve injury-induced changes in pain-associated genes contribute to genesis of neuropathic pain and comorbid anxiety. Phosphorylated CTD interacting factor-1 (PCIF1)-triggered N6, 2′-O-dimethyladenosine (m6Am) mRNA modification represents an additional ...
Yue Huang +17 more
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MAF1 represses CDKN1A through a Pol III-dependent mechanism
eLife, 2015 MAF1 represses Pol III-mediated transcription by interfering with TFIIIB and Pol III. Herein, we found that MAF1 knockdown induced CDKN1A transcription and chromatin looping concurrently with Pol III recruitment.
Yu-Ling Lee +5 more
doaj +3 more sources
Genetic interactions of MAF1 identify a role for Med20 in transcriptional repression of ribosomal protein genes. [PDF]
PLoS Genetics, 2008 Transcriptional repression of ribosomal components and tRNAs is coordinately regulated in response to a wide variety of environmental stresses. Part of this response involves the convergence of different nutritional and stress signaling pathways on Maf1,
Ian M Willis +6 more
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Regulation of RNA polymerase III transcription by Maf1 protein. [PDF]
Acta Biochimica Polonica, 2008 Maf1 was the first protein discovered to regulate polymerase III RNA in yeast and because it is evolutionarily conserved, a Maf1 ortholog also serves to restrain transcription in mouse and human cells. Understanding the mechanism of the regulation has been made possible by recent studies showing that Maf1 is a nuclear/cytoplasmic protein whose ...
Małgorzata, Cieśla, Magdalena, Boguta
openaire +4 more sources
Insulin resistance and exercise-induced insulin sensitization in skeletal muscle: Insights from personalized phosphoproteomics. [PDF]
J Diabetes InvestigInsulin resistance in muscle mainly disrupts non‐canonical insulin signaling pathways. Exercise‐induced MINDY1 S441 phosphorylation improves insulin sensitivity, highlighting its potential role in mediating exercise benefits in metabolic disease.
Masuda S, Matsuzaka T.
europepmc +2 more sources
MAF1 is a chronic repressor of RNA polymerase III transcription in the mouse [PDF]
Scientific Reports, 2019 Abstract Maf1 −/− mice are lean, obesity-resistant and metabolically inefficient. Their increased energy expenditure is thought to be driven by a futile RNA cycle that reprograms metabolism to meet an increased demand for ...
Bonhoure, Nicolas +7 more
openaire +5 more sources
Characterization of a MAF1 knockout mouse model [PDF]
, 2015 L'ARN polymérase 3 transcrit un petit groupe de gènes fortement exprimés et impliqués dans plusieurs mécanismes moléculaires. Les ARNs de transfert ou ARNt représentent plus ou moins la moitié du transcriptome de l'ARN polymérase 3. Ils sont directement impliqués dans la traduction des protéines en agissant comme transporteurs d'acides aminés qui sont ...
Bonhoure, N.
core +2 more sources
Maf1 cooperates with progesterone receptor to repress RNA polymerase III transcription of select tRNAs. [PDF]
Nucleic Acids ResAbstract Progesterone receptors (PRs) can regulate transcription by RNA polymerase III (Pol III), which transcribes small non-coding RNAs, including all transfer RNAs (tRNAs). We previously demonstrated that PR is associated with the Pol III complex at tRNA genes and that progestins downregulate tRNA transcripts in breast tumor models.
Finlay-Schultz J +8 more
europepmc +5 more sources
Maf1 Protein, Repressor of RNA Polymerase III, Indirectly Affects tRNA Processing* [PDF]
Journal of Biological Chemistry, 2011 Maf1 is negative regulator of RNA polymerase III in yeast. We observed high levels of both primary transcript and end-matured, intron-containing pre-tRNAs in the maf1Δ strain. This pre-tRNA accumulation could be overcome by transcription inhibition, arguing against a direct role of Maf1 in tRNA maturation and suggesting saturation of processing ...
Magdalena Rakowska-Boguta +2 more
exaly +3 more sources
Toxoplasma effector MAF1 mediates recruitment of host mitochondria and impacts the host response.
PLoS Biology, 2014 Recent information has revealed the functional diversity and importance of mitochondria in many cellular processes including orchestrating the innate immune response. Intriguingly, several infectious agents, such as Toxoplasma, Legionella, and Chlamydia,
Lena Pernas +6 more
doaj +4 more sources