Results 41 to 50 of about 2,035 (177)
ΜicroRNA‑122 protects against ischemic stroke by targeting Maf1
Experimental and Therapeutic Medicine, 2021 The protection of brain tissue against damage and the reduction of infarct size is crucial for improving patient prognosis following ischemic stroke. Therefore, the present study aimed to investigate the regulatory effect of microRNA (miR)-122 and its target gene repressor of RNA polymerase III transcription MAF1 homolog (Maf1) on the infarct area in ...
Mengmeng, Wang +7 more
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Generation of two iPSC lines from healthy donor with a heterozygous mutation in the VPS13B gene
Stem Cell Research, 2022 The human induced pluripotent stem cell (iPSC) lines, iCS-MAF1-1 and iCS-MAF1-11, were generated from fibroblasts. The donor has a heterozygous mutation in the VPS13B gene, which manifests in her child as Cohen syndrome.
S.A. Chechetkina +12 more
doaj +1 more source
Structural basis of RNA polymerase III transcription repression by Maf1 [PDF]
Nature Structural & Molecular Biology, 2019 ABSTRACT Maf1 is a highly conserved central regulator of transcription by RNA polymerase III (Pol III), and Maf1 activity influences a wide range of phenotypes from metabolic efficiency to lifespan. Here, we present a 3.3 Å cryo-EM structure of yeast Maf1 bound to Pol III, which establishes how Maf1 achieves transcription repression. In
Vorländer, Matthias K. +6 more
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Maf1-mediated repression of RNA polymerase III transcription inhibits tRNA degradation via RTD pathway [PDF]
, 2012 tRNA precursors, which are transcribed by RNA polymerase III, undergo end-maturation, splicing and base modifications. Hypomodified tRNAs, such as tRNAVal(AAC), lacking 7-methylguanosine and 5-methylcytidine modifications, are subject to degradation by a
Boguta, Magdalena +3 more
core +1 more source
KEGG pathway analysis for MAF1.
, 2023 The most significant (FDR) Kegg pathways involved in the MAF1 network are presented. (TIF)
Gabriella Olshefsky (17108682) +2 more
core +1 more source
Frontiers in Immunology, 2020 BackgroundThe NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome has been identified as an important mediator of blood–brain-barrier disruption in sepsis-associated encephalopathy (SAE).
Shenglong Chen +8 more
doaj +1 more source
Journal of Fungi, 2023 In eukaryotes, Maf1 is an essential and specific negative regulator of RNA polymerase (Pol) III. Pol III, which synthesizes 5S RNA and transfer RNAs (tRNAs), is suppressed by Maf1 under the conditions of nutrient starvation or environmental stress. Here,
Bin Qian +3 more
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Maf1, A New PTEN Target Linking RNA and Lipid Metabolism [PDF]
Trends in Endocrinology & Metabolism, 2016 PTEN is a critical tumor suppressor whose dysregulation leads to metabolic disease and cancer. How these diseases are linked at a molecular level is poorly understood. Maf1 is a novel PTEN target that connects PTEN's ability to repress intracellular lipid accumulation with its tumor suppressor function.
Deborah L, Johnson, Bangyan L, Stiles
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CK2-mediated phosphorylation of general repressor Maf1 triggers RNA polymerase III activation [PDF]
, 2011 Maf1 protein is a global negative regulator of Pol III transcription conserved from yeast to man. We report that phosphorylation of Maf1 by casein kinase II (CK2), a highly evolutionarily conserved eukaryotic kinase, is required for efficient Pol III ...
Boguta, Magdalena +4 more
core +1 more source
The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability [PDF]
Journal of Molecular Biology, 2017 MAF1 is a conserved negative regulator of RNA polymerase (pol) III and intracellular lipid homeostasis across species. Here, we show that the MAF1 C-box region negatively regulates its activity. Mutations in Caenorhabditis elegans mafr-1 that truncate the C-box retain the ability to inhibit the transcription of RNA pol III targets, reduce lipid ...
Ajay, Pradhan +3 more
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