Results 41 to 50 of about 1,593 (136)
Novel layers of RNA polymerase III control affecting tRNA gene transcription in eukaryotes [PDF]
Open Biology, 2017 RNA polymerase III (Pol III) transcribes a limited set of short genes in eukaryotes producing abundant small RNAs, mostly tRNA. The originally defined yeast Pol III transcriptome appears to be expanding owing to the application of new methods.
Ewa Leśniewska, Magdalena Boguta
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Two Steps in Maf1-dependent Repression of Transcription by RNA Polymerase III [PDF]
Journal of Biological Chemistry, 2005 In Saccharomyces cerevisiae, Maf1 is essential for mediating the repression of transcription by RNA polymerase (pol) III in response to diverse cellular conditions. These conditions activate distinct signaling pathways that converge at or above Maf1. Thus, Maf1-dependent repression is thought to involve a common set of downstream inhibitory effects on ...
Neelam, Desai +5 more
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Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila. [PDF]
PLoS Genetics, 2018 The small G-protein Ras is a conserved regulator of cell and tissue growth. These effects of Ras are mediated largely through activation of a canonical RAF-MEK-ERK kinase cascade.
Shrivani Sriskanthadevan-Pirahas +3 more
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PLoS ONE, 2013 Mycobacterium africanum is an important cause of tuberculosis (TB) in West Africa. So far, two lineages called M. africanum West African 1 (MAF1) and M. africanum West African 2 (MAF2) have been defined.
Florian Gehre +7 more
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RNA Polymerase III, Ageing and Longevity
Frontiers in Genetics, 2021 Transcription in eukaryotic cells is performed by three RNA polymerases. RNA polymerase I synthesises most rRNAs, whilst RNA polymerase II transcribes all mRNAs and many non-coding RNAs. The largest of the three polymerases is RNA polymerase III (Pol III)
Yavuz Kulaberoglu +5 more
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Emerging Roles for Maf1 beyond the Regulation of RNA Polymerase III Activity [PDF]
Journal of Molecular Biology, 2015 Maf1 was first identified in yeast, and studies in metazoans have primarily focused on examining its role in the repression of transcription that is dependent on RNA polymerase III. Recent work has revealed a novel and conserved function for Maf1 in the maintenance of intracellular lipid pools in Caenorhabditis elegans, mice, and cancer cell lines ...
Akshat, Khanna +2 more
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Loss of the RNA polymerase III repressor MAF1 confers obesity resistance [PDF]
Genes & Development, 2015 MAF1 is a global repressor of RNA polymerase III transcription that regulates the expression of highly abundant noncoding RNAs in response to nutrient availability and cellular stress. Thus, MAF1 function is thought to be important for metabolic economy. Here we show that a whole-body knockout of Maf1
Bonhoure Nicolas +19 more
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Distinct regulation of Maf1 for lifespan extension by Protein kinase A and Sch9
Aging, 2015 The Protein kinase A (PKA) and Sch9 regulates cell growth as well as lifespan in Saccharomyces cerevisiae. Maf1 is a RNA polymerase III (PolIII) inhibitor that tailors 5S rRNA and tRNA production in response to various environmental cues. Both PKA and Sch9 have been shown to phosphorylate Maf1 in vitro at similar amino acids, suggesting a redundancy in
Ying, Cai, Yue-Hua, Wei
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Differential Phosphorylation of RNA Polymerase III and the Initiation Factor TFIIIB in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2015 The production of ribosomes and tRNAs for protein synthesis has a high energetic cost and is under tight transcriptional control to ensure that the level of RNA synthesis is balanced with nutrient availability and the prevailing environmental conditions.
Jaehoon Lee, Robyn D Moir, Ian M Willis
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RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification.
PLoS Genetics, 2015 Control of the differential abundance or activity of tRNAs can be important determinants of gene regulation. RNA polymerase (RNAP) III synthesizes all tRNAs in eukaryotes and it derepression is associated with cancer.
Aneeshkumar G Arimbasseri +6 more
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