Results 61 to 70 of about 1,609 (154)

Regulation of RNA polymerase III transcription by Maf1 protein.

Acta Biochimica Polonica, 2008
Maf1 was the first protein discovered to regulate polymerase III RNA in yeast and because it is evolutionarily conserved, a Maf1 ortholog also serves to restrain transcription in mouse and human cells. Understanding the mechanism of the regulation has been made possible by recent studies showing that Maf1 is a nuclear/cytoplasmic protein whose ...
Małgorzata, Cieśla, Magdalena, Boguta
openaire   +3 more sources

Crystal Structure and Regulation of the Citrus Pol III Repressor MAF1 by Auxin and Phosphorylation [PDF]

Structure, 2017
MAF1 is the main RNA polymerase (Pol) III repressor that controls cell growth in eukaryotes. The Citrus ortholog, CsMAF1, was shown to restrict cell growth in citrus canker disease but its role in plant development and disease is still unclear. We solved the crystal structure of the globular core of CsMAF1, which reveals additional structural elements ...
Santos Soprano, Adriana, Oliveira de Giuseppe, Priscila, Massayoshi Shimo, Hugo, Brenelli Lima, Tatiani, Heleno Batista, Fernanda Aparecida, Lima Righetto, Germanna, Carvalho Pereira, José Geraldo de, Campos Granato, Daniela, Ziem Nascimento, Andrey Fabricio, Cesar Gozzo, Fabio, Lopesde Oliveira, Paulo Sérgio, Migliorini Figueira, Ana Carolina, Costa Smetana, Juliana Helena, Franco Paes Leme, Adriana, Murakami, Mario Tyago, Benedetti, Celso Eduardo   +15 more
openaire   +3 more sources

Loc4Lnc: Accurate prediction of long noncoding RNA subcellular localization via enhanced RNA sequence representation

Quantitative Biology, Volume 13, Issue 3, September 2025.
Abstract Long noncoding RNAs (lncRNAs) are crucial in gene regulation, chromatin architecture, and cellular differentiation, playing significant roles in various diseases and serving as potential biomarkers and therapeutic targets. Understanding their precise subcellular localization is essential for elucidating their functions in biological pathways ...
Yujia Cheng, Xiaoyong Pan, Yang Yang
wiley   +1 more source

Deep Learning Approach for Accurate Segmentation of Sand Boils in Levee Systems

IEEE Access, 2023
Sand boils can contribute to the liquefaction of a portion of the levee, leading to levee failure. Accurately detecting and segmenting sand boils is crucial for effectively monitoring and maintaining levee systems.
Manisha Panta, Md. Tamjidul Hoque, Kendall N. Niles, Joe Tom, Mahdi Abdelguerfi, Maik Falanagin   +5 more
doaj   +1 more source

MAF1 loss protects against ischemic cerebral injury by attenuating NLRP3-mediated pyroptosis

Brain Research Bulletin
Background: Acute ischemic stroke (AIS) is the second leading cause of death worldwide and is associated with high rates of disability and mortality.
Xue Gao, Hanzhi Wang, Lingting Jin, Shumeng Li, Gang Li, Can Cui, Yingying Han   +6 more
doaj   +1 more source

Mammalian Maf1 Is a Negative Regulator of Transcription by All Three Nuclear RNA Polymerases [PDF]

Molecular Cell, 2007
Most eukaryotic transcriptional regulators act in an RNA polymerase (Pol)-selective manner. Here we show that the human Maf1 protein negatively regulates transcription by all three nuclear Pols. Changes in Maf1 expression affect Pol I- and Pol III-dependent transcription in human glioblastoma lines.
Johnson, Sandra S., Zhang, Cheng, Fromm, Jody, Willis, Ian M., Johnson, Deborah L.   +4 more
openaire   +2 more sources

Sub1 and Maf1, two effectors of RNA polymerase III, are involved in the yeast quiescence cycle.

PLoS ONE, 2014
Sub1 and Maf1 exert an opposite effect on RNA polymerase III transcription interfering with different steps of the transcription cycle. In this study, we present evidence that Sub1 and Maf1 also exhibit an opposite role on yeast chronological life span ...
Joël Acker, Ngoc-Thuy-Trinh Nguyen, Marie Vandamme, Arounie Tavenet, Audrey Briand-Suleau, Christine Conesa   +5 more
doaj   +1 more source

Copy Number Variation Discovery in South African Nguni-Sired and Bonsmara-Sired Crossbred Cattle

Animals, 2023
Crossbreeding forms part of Climate-Smart beef production and is one of the strategies to mitigate the effects of climate change. Two Nguni-sired and three Bonsmara-sired crossbred animals underwent whole genome sequencing.
Bhaveni B. Kooverjee, Pranisha Soma, Magrieta A. van der Nest, Michiel M. Scholtz, Frederick W. C. Neser   +4 more
doaj   +1 more source

GRB2 Promotes Malignant Behaviors of Breast Cancer by Modulating the Global Expression and Alternative Splicing Profiles in SK‐BR‐3 Cells Through Binding mRNA

Cancer Medicine, Volume 14, Issue 10, May 2025.
GRB2 as a flexible protein and an RBP that is involved in post‐transcriptional regulation in eukaryotes, influencing all stages of mRNA synthesis, modification, splicing, and stabilization. ABSTRACT Purpose The flexible protein GRB2 interacts with HER1–4 on the cell surface and regulates the development of tumor cells; meanwhile, it is also an RBP that
Wei Liu, Yumian Huang, Lei Qiao, Le Chong, Luhua Xia, Aikeremu Abudurehaman, Hongyu Li   +6 more
wiley   +1 more source

CMV2U‐Net: A U‐shaped network with edge‐weighted features for detecting and localizing image splicing

Journal of Forensic Sciences, Volume 70, Issue 3, Page 1026-1043, May 2025.
Abstract The practice of cutting and pasting portions of one image into another, known as “image splicing,” is commonplace in the field of image manipulation. Image splicing detection using deep learning has been a hot research topic for the past few years.
Arslan Akram, Muhammad Arfan Jaffar, Javed Rashid, Salah Mahmoud Boulaaras, Muhammad Faheem   +4 more
wiley   +1 more source