Results 71 to 80 of about 1,609 (154)

Genomic Prediction and Genome‐Wide Association Studies for Productivity, Conformation and Heat Tolerance Traits in Tropical Smallholder Dairy Cows

open access: yesJournal of Animal Breeding and Genetics, Volume 142, Issue 3, Page 322-341, May 2025.
ABSTRACT Genomic selection (GS) and genome‐wide association studies (GWAS) have not been investigated in Vietnamese dairy cattle, even for basic milk production traits, largely due to the scarcity of individual phenotype recording in smallholder dairy farms (SDFs).
Nguyen N. Bang   +6 more
wiley   +1 more source

Comprehensive Characterization of Toxoplasma Acyl Coenzyme A-Binding Protein TgACBP2 and Its Critical Role in Parasite Cardiolipin Metabolism

open access: yesmBio, 2018
Acyl coenzyme A (CoA)-binding protein (ACBP) can bind acyl-CoAs with high specificity and affinity, thus playing multiple roles in cellular functions. Mitochondria of the apicomplexan parasite Toxoplasma gondii have emerged as key organelles for lipid ...
Yong Fu   +6 more
doaj   +1 more source

Circadian Control of Protein Synthesis

open access: yesBioEssays, Volume 47, Issue 3, March 2025.
The circadian clock maintains proteostasis in part through rhythmic control of protein synthesis. We propose that, across the day, translation alternates between distinct mechanisms to optimize energy efficiency and regulate complex assembly. This temporal compartmentalization produces alternating phases of slow specialized translation and rapid ...
Nathan R. James, John S. O'Neill
wiley   +1 more source

Maf1 Is an Essential Mediator of Diverse Signals that Repress RNA Polymerase III Transcription [PDF]

open access: yesMolecular Cell, 2002
Maf1 is a putative repressor of RNA polymerase (pol) III transcription that is conserved from yeast to humans. Here we show that Maf1 is a common component of multiple signaling pathways in S. cerevesiae that sense changes in the cellular environment and repress pol III transcription.
Upadhya, Rajendra   +2 more
openaire   +2 more sources

Differential release of extracellular vesicle tRNA from oxidative stressed renal cells and ischemic kidneys

open access: yesScientific Reports, 2022
While urine-based liquid biopsy has expanded to the analyses of extracellular nucleic acids, the potential of transfer RNA (tRNA) encapsulated within extracellular vesicles has not been explored as a new class of urine biomarkers for kidney injury. Using
Hee Kyung Lee   +7 more
doaj   +1 more source

MaOAOA: A Novel Many‐Objective Arithmetic Optimization Algorithm for Solving Engineering Problems

open access: yesEngineering Reports, Volume 7, Issue 3, March 2025.
MaOAOA introduces an innovative many‐objective optimization framework combining an Information Feedback Mechanism, reference point‐based selection, and niche preservation strategies. Its effectiveness surpasses leading algorithms in convergence, diversity, and computational efficiency across benchmark and real‐world engineering problems, establishing ...
Pradeep Jangir   +5 more
wiley   +1 more source

Metabolism Meets Translation: Dietary and Metabolic Influences on tRNA Modifications and Codon Biased Translation

open access: yesWIREs RNA, Volume 16, Issue 2, March/April 2025.
Diet influences tRNA modifications and metabolism. Metabolic processes are essential for the synthesis of many tRNA modifications, which can impact metabolism by altering mRNA translation and bioenergetics pathways. We discuss the importance of studying tRNA modifications from the viewpoint of cellular metabolism to fully grasp the complexity of ...
Sherif Rashad, Aseel Marahleh
wiley   +1 more source

An Adaptive Reference Vector Adjustment Strategy and Improved Angle-Penalized Value Method for RVEA

open access: yesComplexity, 2021
Decomposition-based evolutionary multiobjective algorithms (MOEAs) divide a multiobjective problem into several subproblems by using a set of predefined uniformly distributed reference vectors and can achieve good overall performance especially in ...
Wenbo Qiu   +4 more
doaj   +1 more source

The role of acetylation and deacetylation in cancer metabolism

open access: yesClinical and Translational Medicine, Volume 15, Issue 1, January 2025.
Protein acetylation and deacetylation influence metabolic reprogramming in tumour cells by regulating the function and activity of various signalling pathways, transcription factors and metabolic enzymes. Abstract As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to ...
Cuicui Wang, Xiaoxin Ma
wiley   +1 more source

maf1 mutation alters the subcellular localization of the Mod5 protein in yeast.

open access: yesActa Biochimica Polonica, 1994
Two forms of Mod5p, a tRNA modification enzyme, are found in three intracellular compartments, mitochondria, cytoplasm and nucleus, but are encoded by a single MOD5 gene. The two forms of the enzyme, Mod5p-I and Mod5p-II differ at the N-termini and are produced by initiation of translation at different start codons. Mod5p-I does contain a mitochondrial
M, Murawski   +5 more
openaire   +3 more sources

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