Results 91 to 100 of about 2,035 (177)
Journal of Animal Breeding and Genetics, Volume 142, Issue 3, Page 322-341, May 2025.ABSTRACT Genomic selection (GS) and genome‐wide association studies (GWAS) have not been investigated in Vietnamese dairy cattle, even for basic milk production traits, largely due to the scarcity of individual phenotype recording in smallholder dairy farms (SDFs).
Nguyen N. Bang +6 more
wiley +1 more source
Maf1 is regulated through PI3K/AKT/FOXO1 signaling.
, 2014 (A) Pharmacologic inhibition of PI3K signaling increases Maf1 expression. MEF and HepG2 cells were treated with LY294002 or DMSO control for 6 hrs. Protein lysates were subjected to immunoblot analysis.
Louis Dubeau (193226) +7 more
core +1 more source
Circadian Control of Protein Synthesis
BioEssays, Volume 47, Issue 3, March 2025.The circadian clock maintains proteostasis in part through rhythmic control of protein synthesis. We propose that, across the day, translation alternates between distinct mechanisms to optimize energy efficiency and regulate complex assembly. This temporal compartmentalization produces alternating phases of slow specialized translation and rapid ...
Nathan R. James, John S. O'Neill
wiley +1 more source
maf1 mutation alters the subcellular localization of the Mod5 protein in yeast.
Acta Biochimica Polonica, 1994 Two forms of Mod5p, a tRNA modification enzyme, are found in three intracellular compartments, mitochondria, cytoplasm and nucleus, but are encoded by a single MOD5 gene. The two forms of the enzyme, Mod5p-I and Mod5p-II differ at the N-termini and are produced by initiation of translation at different start codons. Mod5p-I does contain a mitochondrial
M, Murawski +5 more
openaire +3 more sources
Maf1 Is an Essential Mediator of Diverse Signals that Repress RNA Polymerase III Transcription [PDF]
Molecular Cell, 2002 Maf1 is a putative repressor of RNA polymerase (pol) III transcription that is conserved from yeast to humans. Here we show that Maf1 is a common component of multiple signaling pathways in S. cerevesiae that sense changes in the cellular environment and repress pol III transcription.
Upadhya, Rajendra +2 more
openaire +2 more sources
MaOAOA: A Novel Many‐Objective Arithmetic Optimization Algorithm for Solving Engineering Problems
Engineering Reports, Volume 7, Issue 3, March 2025.MaOAOA introduces an innovative many‐objective optimization framework combining an Information Feedback Mechanism, reference point‐based selection, and niche preservation strategies. Its effectiveness surpasses leading algorithms in convergence, diversity, and computational efficiency across benchmark and real‐world engineering problems, establishing ...
Pradeep Jangir +5 more
wiley +1 more source
WIREs RNA, Volume 16, Issue 2, March/April 2025.Diet influences tRNA modifications and metabolism. Metabolic processes are essential for the synthesis of many tRNA modifications, which can impact metabolism by altering mRNA translation and bioenergetics pathways. We discuss the importance of studying tRNA modifications from the viewpoint of cellular metabolism to fully grasp the complexity of ...
Sherif Rashad, Aseel Marahleh
wiley +1 more source
Unraveling the Role of MAF1 Mutations in Accelerating Aging [PDF]
The regulation of RNA polymerase III by MAF1 is crucial for cellular homeostasis. Its disruption is linked to accelerated aging and an increased risk of age-related cancers.
Franco, Sofia
core +2 more sources
TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast
Biology Open, 2012 Summary TOR (Target Of Rapamycin) signalling coordinates cell growth and division in response to changes in the nutritional environment of the cell. TOR kinases form two distinct complexes: TORC1 and TORC2.
Wei Du +4 more
doaj +1 more source
The role of acetylation and deacetylation in cancer metabolism
Clinical and Translational Medicine, Volume 15, Issue 1, January 2025.Protein acetylation and deacetylation influence metabolic reprogramming in tumour cells by regulating the function and activity of various signalling pathways, transcription factors and metabolic enzymes. Abstract As a hallmark of cancer, metabolic reprogramming adjusts macromolecular synthesis, energy metabolism and redox homeostasis processes to ...
Cuicui Wang, Xiaoxin Ma
wiley +1 more source