Results 1 to 10 of about 201,151 (364)
Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins [PDF]
Journal of Biological Chemistry, 2001 Ectopic production of the EVI1 transcriptional repressor zinc finger protein is seen in 4--6% of human acute myeloid leukemias. Overexpression also transforms Rat1 fibroblasts by an unknown mechanism, which is likely to be related to its role in leukemia
Walker, Mark +6 more
core +4 more sources
Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins. [PDF]
PLoS Genetics, 2013 Robert J Klose +4 more
doaj +2 more sources
A Tunable Genetic Switch Based on RNAi and Repressor Proteins for Regulating Gene Expression in Mammalian Cells [PDF]
Cell, 2007 Tara L Deans +2 more
exaly +2 more sources
Protein Expression and Purification, 2009 NMR studies of structural aspects of allosteric regulation by the Lac repressor requires overexpression and isotope labeling of the protein. The size of the repressor makes it a challenging target, putting constraints on both expression conditions and ...
Robert Kaptein +2 more
exaly +1 more source
Interplay of protein and DNA structure revealed in simulations of the lac operon. [PDF]
PLoS ONE, 2013 The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely spaced sites along a genome and forces the intervening DNA into a loop.
Luke Czapla +3 more
doaj +1 more source
Nature Communications, 2022 Bacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains.
Reliza J. McGinnis +11 more
doaj +1 more source
PLoS ONE, 2023 Protein tandem repeats (TRs) are motifs comprised of near-identical contiguous sequence duplications. They are found in approximately 14% of all proteins and are implicated in diverse biological functions facilitating both structured and disordered ...
James A. Davey, Natalie K. Goto
doaj +2 more sources
Dissecting and circumventing the requirement for RAM in CSL-dependent Notch signaling. [PDF]
PLoS ONE, 2012 The Notch signaling pathway is an intercellular communication network vital to metazoan development. Notch activation leads to the nuclear localization of the intracellular portion (NICD) of the Notch receptor.
Scott E Johnson, Douglas Barrick
doaj +1 more source
Optimization of Cdx Transcription Factors Characteristics
Журнал інженерних наук, 2023 This study presents a new application of TOPSIS for the optimization of transcription factors characteristics. This application is essential as it can help compare the characteristics of these proteins and determine the optimized output of their ...
Javanbakht T.
doaj +1 more source
The N-terminal domain of the repressor of Staphylococcus aureus phage Φ11 possesses an unusual dimerization ability and DNA binding affinity. [PDF]
PLoS ONE, 2014 Bacteriophage Φ11 uses Staphylococcus aureus as its host and, like lambdoid phages, harbors three homologous operators in between its two divergently oriented repressor genes. None of the repressors of Φ11, however, showed binding to all three operators,
Anindya Biswas +2 more
doaj +1 more source