Results 1 to 10 of about 191,078 (267)
Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins. [PDF]
PLoS Genetics, 2013 Robert J Klose +4 more
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Interplay of protein and DNA structure revealed in simulations of the lac operon. [PDF]
PLoS ONE, 2013 The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely spaced sites along a genome and forces the intervening DNA into a loop.
Luke Czapla +3 more
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Nature Communications, 2022 Bacteriophage repressor proteins downregulate viral lytic gene expression. Herein, the authors present the X-ray crystal structure of a monomeric repressor that binds an asymmetric DNA sequence using two independent domains.
Reliza J. McGinnis +11 more
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PLoS ONE, 2023 Protein tandem repeats (TRs) are motifs comprised of near-identical contiguous sequence duplications. They are found in approximately 14% of all proteins and are implicated in diverse biological functions facilitating both structured and disordered ...
James A. Davey, Natalie K. Goto
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Dissecting and circumventing the requirement for RAM in CSL-dependent Notch signaling. [PDF]
PLoS ONE, 2012 The Notch signaling pathway is an intercellular communication network vital to metazoan development. Notch activation leads to the nuclear localization of the intracellular portion (NICD) of the Notch receptor.
Scott E Johnson, Douglas Barrick
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Optimization of Cdx Transcription Factors Characteristics
Журнал інженерних наук, 2023 This study presents a new application of TOPSIS for the optimization of transcription factors characteristics. This application is essential as it can help compare the characteristics of these proteins and determine the optimized output of their ...
Javanbakht T.
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Evi-1 Transforming and Repressor Activities Are Mediated by CtBP Co-repressor Proteins [PDF]
Journal of Biological Chemistry, 2001 Ectopic production of the EVI1 transcriptional repressor zinc finger protein is seen in 4--6% of human acute myeloid leukemias. Overexpression also transforms Rat1 fibroblasts by an unknown mechanism, which is likely to be related to its role in leukemia and which depends upon its repressor activity.
Palmer, Susan +6 more
openaire +2 more sources
The N-terminal domain of the repressor of Staphylococcus aureus phage Φ11 possesses an unusual dimerization ability and DNA binding affinity. [PDF]
PLoS ONE, 2014 Bacteriophage Φ11 uses Staphylococcus aureus as its host and, like lambdoid phages, harbors three homologous operators in between its two divergently oriented repressor genes. None of the repressors of Φ11, however, showed binding to all three operators,
Anindya Biswas +2 more
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Evidence-Based Structural Model of the Staphylococcal Repressor Protein: Separation of Functions into Different Domains. [PDF]
PLoS ONE, 2015 Horizontal transfer of mobile genetic elements within Staphylococci is of high biomedical significance as such elements are frequently responsible for virulence and toxic effects.
Kinga Nyíri +4 more
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mSphere, 2020 Copper is broadly toxic to bacteria. As such, bacteria have evolved specialized copper export systems (cop operons) often consisting of a DNA-binding/copper-responsive regulator (which can be a repressor or activator), a copper chaperone, and a copper ...
Henrik O’Brien +5 more
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