Results 11 to 20 of about 191,078 (267)

Repressor of temperate mycobacteriophage L1 harbors a stable C-terminal domain and binds to different asymmetric operator DNAs with variable affinity

Virology Journal, 2007
Background Lysogenic mode of life cycle of a temperate bacteriophage is generally maintained by a protein called 'repressor'. Repressor proteins of temperate lambdoid phages bind to a few symmetric operator DNAs in order to regulate their gene expression.
Mandal Nitai C, Das Malabika, Chanda Palas K, Chattoraj Partho, Bandhu Amitava, Ganguly Tridib, Sau Subrata   +6 more
doaj   +1 more source

BiFCROS: A Low-Background Fluorescence Repressor Operator System for Labeling of Genomic Loci

G3: Genes, Genomes, Genetics, 2017
Fluorescence-based methods are widely used to analyze elementary cell processes such as DNA replication or chromosomal folding and segregation. Labeling DNA with a fluorescent protein allows the visualization of its temporal and spatial organization. One
Sarah Milbredt, Torsten Waldminghaus
doaj   +1 more source

KPNB1 mediates PER/CRY nuclear translocation and circadian clock function

eLife, 2015
Regulated nuclear translocation of the PER/CRY repressor complex is critical for negative feedback regulation of the circadian clock of mammals. However, the precise molecular mechanism is not fully understood.
Yool Lee, A Reum Jang, Lauren J Francey, Amita Sehgal, John B Hogenesch   +4 more
doaj   +1 more source

Clearance of an amyloid-like translational repressor is governed by 14-3-3 proteins

Cell Reports, 2022
Summary: Amyloids are fibrous protein aggregates associated with age-related diseases. While these aggregates are typically described as irreversible and pathogenic, some cells use reversible amyloid-like structures that serve important functions.
S. Grace Herod, Annie Dyatel, Stefanie Hodapp, Marko Jovanovic, Luke E. Berchowitz   +4 more
doaj   +1 more source

Mobility of the native Bacillus subtilis conjugative plasmid pLS20 is regulated by intercellular signaling.

PLoS Genetics, 2013
Horizontal gene transfer mediated by plasmid conjugation plays a significant role in the evolution of bacterial species, as well as in the dissemination of antibiotic resistance and pathogenicity determinants.
Praveen K Singh, Gayetri Ramachandran, Ricardo Ramos-Ruiz, Ramón Peiró-Pastor, David Abia, Ling J Wu, Wilfried J J Meijer   +6 more
doaj   +1 more source

Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage

Viruses, 2013
In a λimm434 lysogen, two proteins are expressed from the integrated prophage. Both are encoded by the same mRNA whose transcription initiates at the PRM promoter. One protein is the 434 repressor, needed for the establishment and maintenance of
Paul Shkilnyj, Michael P. Colon, Gerald B. Koudelka   +2 more
doaj   +1 more source

Bacteriophage crosstalk: coordination of prophage induction by trans-acting antirepressors.

PLoS Genetics, 2011
Many species of bacteria harbor multiple prophages in their genomes. Prophages often carry genes that confer a selective advantage to the bacterium, typically during host colonization.
Sébastien Lemire, Nara Figueroa-Bossi, Lionello Bossi   +2 more
doaj   +1 more source

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Cell Reports, 2021
Summary: Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophage ...
Fabrizio Simeoni, Isabel Romero-Camarero, Francesco Camera, Fabio M.R. Amaral, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Michael Lie-A-Ling, Georges Lacaud, Daniel H. Wiseman, Jason S. Carroll, Tim C.P. Somervaille   +11 more
doaj   +1 more source

Proteins of the ETS family with transcriptional repressor activity [PDF]

Oncogene, 2000
ETS proteins form one of the largest families of signal-dependent transcriptional regulators, mediating cellular proliferation, differentiation and tumorigenesis. Most of the known ETS proteins have been shown to activate transcription. However, four ETS proteins (YAN, ERF, NET and TEL) can act as transcriptional repressors.
G, Mavrothalassitis, J, Ghysdael
openaire   +2 more sources

Two-Hybrid System for Characterization of Protein-Protein Interactions in E. coli

BioTechniques, 2000
The yeast two-hybrid system has been used to characterize many protein-protein interactions. A two-hybrid system for E. coli was constructed in which one hybrid protein bound to a specific DNA site recruits another to an adjacent DNA binding site.
Lori B. Hays, Yuen-Shing A. Chen, James C. Hu   +2 more
doaj   +1 more source