Heterotropic regulation and negative homotropic cooperativity. [PDF]
FEBS Open BioWe identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Morea V +5 more
europepmc +2 more sources
The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate: sugar phosphotransferase system (PTS) in Corynebacterium glutamicum [PDF]
, 2007 Gaigalat L, Schlüter J-P, Hartmann M, et al. The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate: sugar phosphotransferase system (PTS) in Corynebacterium glutamicum. BMC Molecular Biology. 2007;8(1)
Mormann, Sascha +14 more
core +1 more source
Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage
Viruses, 2013 In a λimm434 lysogen, two proteins are expressed from the integrated prophage. Both are encoded by the same mRNA whose transcription initiates at the PRM promoter. One protein is the 434 repressor, needed for the establishment and maintenance of
Paul Shkilnyj +2 more
doaj +1 more source
A dominant repressor version of the tomatoSl-ERF.B3gene confers ethylene hypersensitivity via feedback regulation of ethylene signaling and response components [PDF]
, 2013 Ethylene Response Factors (ERFs) are downstream components of the ethylene signal transduction pathway, although their role in ethylene-dependent developmental processes remains poorly understood. As the ethylene-inducible tomato Sl-ERF.B3 has been shown
Kesari, Ravi +9 more
core +1 more source
Bacteriophage crosstalk: coordination of prophage induction by trans-acting antirepressors.
PLoS Genetics, 2011 Many species of bacteria harbor multiple prophages in their genomes. Prophages often carry genes that confer a selective advantage to the bacterium, typically during host colonization.
Sébastien Lemire +2 more
doaj +1 more source
Cell Reports, 2021 Summary: Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophage ...
Fabrizio Simeoni +11 more
doaj +1 more source
Two-Hybrid System for Characterization of Protein-Protein Interactions in E. coli
BioTechniques, 2000 The yeast two-hybrid system has been used to characterize many protein-protein interactions. A two-hybrid system for E. coli was constructed in which one hybrid protein bound to a specific DNA site recruits another to an adjacent DNA binding site.
Lori B. Hays +2 more
doaj +1 more source
Spatial epigenetic control of mono- and bistable gene expression. [PDF]
PLoS Biology, 2010 Bistability in signaling networks is frequently employed to promote stochastic switch-like transitions between cellular differentiation states. Differentiation can also be triggered by antagonism of activators and repressors mediated by epigenetic ...
János Z Kelemen +3 more
doaj +1 more source
Regulation of Dpp target genes by Mad/Medea and Brinker [PDF]
, 2009 The TGF-β family member Decapentaplegic (Dpp) is a key regulator of patterning and growth in development of Drosophila. Binding of Dpp to its receptors triggers the activation of the intracellular Smad pathway.
Weiss, Alexander
core +1 more source
Characterization of Schnurri : an integral component of the Dpp-signaling pathway in "Drosophila melanogaster" [PDF]
, 2004 Signaling by the transforming growth factor-β (TGF-β) family of ligands plays a crucial role during development and tissue homeostasis in all multicellular organisms. The signal transduction pathway is highly conserved and relatively simple.
Hartmann, Britta
core +1 more source