Results 21 to 30 of about 201,151 (364)

Bacteriophage 434 Hex Protein Prevents RecA-Mediated Repressor Autocleavage

Viruses, 2013
In a λimm434 lysogen, two proteins are expressed from the integrated prophage. Both are encoded by the same mRNA whose transcription initiates at the PRM promoter. One protein is the 434 repressor, needed for the establishment and maintenance of
Paul Shkilnyj, Michael P. Colon, Gerald B. Koudelka   +2 more
doaj   +1 more source

Proteins of the ETS family with transcriptional repressor activity [PDF]

Oncogene, 2000
ETS proteins form one of the largest families of signal-dependent transcriptional regulators, mediating cellular proliferation, differentiation and tumorigenesis. Most of the known ETS proteins have been shown to activate transcription. However, four ETS proteins (YAN, ERF, NET and TEL) can act as transcriptional repressors.
G, Mavrothalassitis, J, Ghysdael
openaire   +2 more sources

The transcriptional repressor protein PRH interacts with the proteasome [PDF]

Biochemical Journal, 2003
PRH (proline-rich homeodomain protein)/Hex is important in the control of cell proliferation and differentiation. We have shown previously that PRH contains two domains that can bring about transcriptional repression independently; the PRH homeodomain represses transcription by binding to TATA box sequences, whereas the proline-rich N-terminal domain ...
Bess, KL, Swingler, TE, Rivett, AJ, Gaston, K, Jayaraman, P-S   +4 more
openaire   +3 more sources

Two-Hybrid System for Characterization of Protein-Protein Interactions in E. coli

BioTechniques, 2000
The yeast two-hybrid system has been used to characterize many protein-protein interactions. A two-hybrid system for E. coli was constructed in which one hybrid protein bound to a specific DNA site recruits another to an adjacent DNA binding site.
Lori B. Hays, Yuen-Shing A. Chen, James C. Hu   +2 more
doaj   +1 more source

Bacteriophage crosstalk: coordination of prophage induction by trans-acting antirepressors.

PLoS Genetics, 2011
Many species of bacteria harbor multiple prophages in their genomes. Prophages often carry genes that confer a selective advantage to the bacterium, typically during host colonization.
Sébastien Lemire, Nara Figueroa-Bossi, Lionello Bossi   +2 more
doaj   +1 more source

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Cell Reports, 2021
Summary: Despite absent expression in normal hematopoiesis, the Forkhead factor FOXC1, a critical mesenchymal differentiation regulator, is highly expressed in ∼30% of HOXAhigh acute myeloid leukemia (AML) cases to confer blocked monocyte/macrophage ...
Fabrizio Simeoni, Isabel Romero-Camarero, Francesco Camera, Fabio M.R. Amaral, Oliver J. Sinclair, Evangelia K. Papachristou, Gary J. Spencer, Michael Lie-A-Ling, Georges Lacaud, Daniel H. Wiseman, Jason S. Carroll, Tim C.P. Somervaille   +11 more
doaj   +1 more source

Regulation of Dpp target genes by Mad/Medea and Brinker [PDF]

, 2009
The TGF-β family member Decapentaplegic (Dpp) is a key regulator of patterning and growth in development of Drosophila. Binding of Dpp to its receptors triggers the activation of the intracellular Smad pathway.
Weiss, Alexander
core   +1 more source

Spatial epigenetic control of mono- and bistable gene expression. [PDF]

PLoS Biology, 2010
Bistability in signaling networks is frequently employed to promote stochastic switch-like transitions between cellular differentiation states. Differentiation can also be triggered by antagonism of activators and repressors mediated by epigenetic ...
János Z Kelemen, Prasuna Ratna, Simone Scherrer, Attila Becskei   +3 more
doaj   +1 more source

The c1 repressor of bacteriophage P1. Isolation and characterization of the repressor protein.

Journal of Biological Chemistry, 1988
The c1 repressor gene of bacteriophage P1 is located on P1 DNA EcoRI fragment 7 (Sternberg, N. (1979) Virology 96, 129-142). Subfragments of P1 DNA EcoRI fragment 7 were cloned into expression vectors, and the c1 repressor protein from P1 wild-type phage and a revertant of a temperature-sensitive repressor mutant were overproduced in Escherichia coli ...
B, Dreiseikelmann, M, Velleman, H, Schuster   +2 more
openaire   +2 more sources

The STAR protein QKI-6 is a translational repressor [PDF]

Proceedings of the National Academy of Sciences, 1999
The signal transduction and activation of RNA (STAR) family of RNA-binding proteins, whose members are evolutionarily conserved from yeast to humans, are important for a number of developmental decisions. For example, in the mouse, quaking proteins (QKI-5, QKI-6, and QKI-7) are essential for embryogenesis and ...
L, Saccomanno, C, Loushin, E, Jan, E, Punkay, K, Artzt, E B, Goodwin   +5 more
openaire   +2 more sources