Results 41 to 50 of about 201,151 (364)

Direct observation of dimerization between different CREB1 isoforms in a living cell. [PDF]

PLoS ONE, 2011
Cyclic AMP-responsive element binding protein 1 (CREB1) plays multiple functions as a transcription factor in gene regulation. CREB1 proteins are also known to be expressed in several spliced isoforms that act as transcriptional activators or repressors.
Hisayo Sadamoto, Kenta Saito, Hideki Muto, Masataka Kinjo, Etsuro Ito   +4 more
doaj   +1 more source

Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons [PDF]

, 2008
Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (INa) and excitability in ...
Moffat, K G, Weston, Andrew J., Baines, Richard A., Gerber, Andre P., Baines, R A, Muraro, Nara I., Luschnig, Stefan, Gerber, A P, Baines, Richard A.; id_orcid, Weston, A J, Moffat, Kevin G., Muraro, N I, Luschnig, S   +12 more
core   +1 more source

Repressor fusions as a tool to study protein–protein interactions [PDF]

Structure, 1995
Genetic reporter systems are necessarily limited in the kinds of information they can provide. The most obvious limitation is that the insides of cells are complex. The phenotype of a gene fusion protein will be determined not only by the property we wish to assay, but also by other effects of the intracellular environment on the chimeric gene product,
openaire   +2 more sources

A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis [PDF]

The Plant Cell, 2015
Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells.
Nathalie Gonzalez, Laurens Pauwels, Alexandra Baekelandt, Liesbeth De Milde, Jelle Van Leene, Nienke Besbrugge, Ken S. Heyndrickx, Amparo Cuéllar Pérez, Astrid Nagels Durand, Rebecca De Clercq, Eveline Van De Slijke, Robin Vanden Bossche, Dominique Eeckhout, Kris Gevaert, Klaas Vandepoele, Geert De Jaeger, Alain Goossens, Dirk Inzé   +17 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Revisiting Allostery in the Lac Repressor Protein [PDF]

Biophysical Journal, 2015
The lac repressor protein (lac) is an allosterically regulated transcription factor which controls expression of the lac operon in bacteria. Binding of a small molecule inducer to a site 40A away from the DNA-binding domain relieves repression through what is thought to be local unfolding of the hinge helix.
Stetz, Matthew A., Carter, Marie V., Valentine, Kathleen G., Wand, A. Joshua   +3 more
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Biochemical characterization of bacteriophage IPhane7 repressor proteins [PDF]

, 2021
Bacteriophages are viruses that infect bacteria and can utilize two different pathways after infection; the lytic or lysogenic cycles. During the lytic cycle, the bacteriophage hijacks the bacterial machinery to replicate itself and destroy the bacterial
NC DOCKS at Western Carolina University, Renaud, Vance, Cafferty, Erin   +2 more
core  

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors [PDF]

Biochemical Journal, 2008
The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a transcription factor that functions as an important regulator of vertebrate development and many other processes in the adult including haematopoiesis.
Desjobert, C, Noy, P, Swingler, T, Williams, H, Gaston, K, Jayaraman, P-S   +5 more
openaire   +5 more sources