Results 41 to 50 of about 290,663 (301)

Promoter keyholes enable specific and persistent multi-gene expression programs in primary T cells without genome modification [PDF]

, 2020
Non-invasive epigenome editing is a promising strategy for engineering gene expression programs, yet potency, specificity, and persistence remain challenging.
Acosta, Reyes, Baker, David, Bates, Daniel, Bloom, Jordan, Boyken, Scott E., Chen, Zibo, Ciarlo, Christie, Dunn, Douglass, Federation, Alexander, Funnell, Alister, Green, Shon, Heberlein, Gregory, Liao, Hanna, Nandakumar, Vivek, Otterman, Ericka, Pearl, Jocelynn, Queitsch, Konstantin, Sandstrom, Richard, Schanzer, Elaine, Stamatoyannopoulos, John A., Urnov, Fyodor D., Van Biber, Benjamin, Vong, Shinny, Wang, Hao, Wilken, Matthew S., Zrazhevskey, Pavel   +25 more
core  

A Repressor Protein Complex Regulates Leaf Growth in Arabidopsis [PDF]

The Plant Cell, 2015
Cell number is an important determinant of final organ size. In the leaf, a large proportion of cells are derived from the stomatal lineage. Meristemoids, which are stem cell-like precursor cells, undergo asymmetric divisions, generating several pavement cells adjacent to the two guard cells.
Nathalie Gonzalez, Laurens Pauwels, Alexandra Baekelandt, Liesbeth De Milde, Jelle Van Leene, Nienke Besbrugge, Ken S. Heyndrickx, Amparo Cuéllar Pérez, Astrid Nagels Durand, Rebecca De Clercq, Eveline Van De Slijke, Robin Vanden Bossche, Dominique Eeckhout, Kris Gevaert, Klaas Vandepoele, Geert De Jaeger, Alain Goossens, Dirk Inzé   +17 more
openaire   +3 more sources

Direct observation of dimerization between different CREB1 isoforms in a living cell. [PDF]

PLoS ONE, 2011
Cyclic AMP-responsive element binding protein 1 (CREB1) plays multiple functions as a transcription factor in gene regulation. CREB1 proteins are also known to be expressed in several spliced isoforms that act as transcriptional activators or repressors.
Hisayo Sadamoto, Kenta Saito, Hideki Muto, Masataka Kinjo, Etsuro Ito   +4 more
doaj   +1 more source

CopY-like Copper Inducible Repressors are Putative ‘Winged Helix’ Proteins [PDF]

Biometals, 2006
CopY of Enterococcus hirae is a well characterized copper-responsive repressor involved in copper homeostasis. In the absence of copper, it binds to the promoter. In high copper, the CopZ copper chaperone donates copper to CopY, thereby releasing it from the promoter and allowing transcription of the downstream copper homeostatic genes of the cop ...
Portmann, Reto, Poulsen, Kristian, Wimmer, Reinhard, Solioz, Marc   +3 more
openaire   +5 more sources

The short-lived MATα2 transcriptional regulator is ubiquitinated in vivo [PDF]

, 1991
The substrates of ubiquitin-dependent proteolytic pathways include both damaged or otherwise abnormal proteins and undamaged proteins that are naturally short-lived. Few specific examples of the latter class have been identified, however.
Chau, Vincent, Ellison, Michael J., Hochstrasser, Mark, Varshavsky, Alexander   +3 more
core  

Designer Gene Networks: Towards Fundamental Cellular Control

, 2001
The engineered control of cellular function through the design of synthetic genetic networks is becoming plausible. Here we show how a naturally occurring network can be used as a parts list for artificial network design, and how model formulation leads ...
Ackers, Arkin, Barkai, Becksei, Bialek, Bray, Chen, Dickson, Elowitz, Endy, Gardner, Gillespie, Glass, Glass, Glass, Hammond, Harada, Harding, Hartwell, Hasty, Jacob, Johnson, Johnson, Kauffman, Keller, Lauffenburger, Lowman, McAdams, McAdams, McAdams, McClure, Meyer, Monod, Monod, Moran, Novak, Novak, Novick, Ohlendorf, Palsson, Ptaschne, Reinitz, Rozanov, Samoilov, Sancho, Savageau, Savageau, Savageau, Shea, Smolen, Sveiczer, Szafranski, Tyson, Villaverde, von Hippel, Wolf, Wong   +56 more
core   +1 more source

Cholesterol, a repressor of natriuretic proteins

The FASEB Journal, 2019
Salt‐sensitivity in Dahl rats is due, in part, to the reduction of hemoxygenase‐1 (HO1), cyclooxygenase 2 (COX2), and nitric oxide synthase‐2 (NOS2) in the renal medulla. Renal overexpression of HIF1‐α, a regulator of HO1, COX2, and NOS2, enhances salt and water excretion and reduces blood pressure. Cholesterol (chol) incorporation into collecting duct
Robert Repetti, Jennifer Meth, Daniel Flores, Lisa M Satlin, Rajeev Rohatgi   +4 more
openaire   +1 more source

Revisiting Allostery in the Lac Repressor Protein [PDF]

Biophysical Journal, 2015
The lac repressor protein (lac) is an allosterically regulated transcription factor which controls expression of the lac operon in bacteria. Binding of a small molecule inducer to a site 40A away from the DNA-binding domain relieves repression through what is thought to be local unfolding of the hinge helix.
Stetz, Matthew A., Carter, Marie V., Valentine, Kathleen G., Wand, A. Joshua   +3 more
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. [PDF]

, 2020
Mammalian circadian rhythms are generated by a transcription-based feedback loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2), which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24 hr periodicity ...
Abraham, Adams, Anand, Aryal, Battye, Beckett, Berendsen, Brautigam, Bussi, Czarna, Czarna, Edwards, Emsley, Evans, Fairhead, Fuxreiter, Gao, Gekakis, Griffin, Gustafson, Hirota, Hitomi, Huang, Khan, Kim, Kiyohara, Koike, Lee, Levy, Li, Lindorff-Larsen, Liu, Liu, Ludtke, López-Llano, McClendon, McGibbon, Michael, Michael, Miyazaki, Moffett, Nangle, Ode, Park, Park, Parrinello, Partch, Partch, Patke, Pettersen, Preitner, Rapp, Rosensweig, Sancar, Sato, Scheres, Schmalen, Suloway, Takahashi, Ukai-Tadenuma, van der Horst, van Zundert, Vitaterna, Voss, Wagner, Winn, Xing, Xu, Yagita, Zhang, Zhu   +70 more
core   +3 more sources