Results 51 to 60 of about 1,854,175 (305)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Auxin-sensitive Aux/IAA proteins mediate drought tolerance in Arabidopsis by regulating glucosinolate levels

Nature Communications, 2019
Brassicaceae produce glucosinolates to protect against herbivory and pathogens. Here the authors show that auxin-sensitive Aux/IAA repressor proteins regulate aliphatic glucosinolate levels in Arabidopsis and this promotes stomatal closure via reactive ...
Mohammad Salehin, Baohua Li, Michelle Tang, Ella Katz, Liang Song, Joseph R. Ecker, Daniel J. Kliebenstein, Mark Estelle   +7 more
doaj   +1 more source

Analysis of Rice Proteins with DLN Repressor Motif/S

, 2019
Transcriptional regulation includes both activation and repression of downstream genes. In plants, a well-established class of repressors are proteins with an ERF-associated amphiphilic repression/EAR domain.
Purnima Singh, Iny Mathew, Pinky Agarwal, Akhilesh Tyagi, Ankit Verma   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Nature Communications, 2019
PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins ...
Mariya I. Goncheva, Ronald S. Flannagan, Brigid E. Sterling, Holly A. Laakso, Nancy C. Friedrich, Julienne C. Kaiser, David W. Watson, Christy H. Wilson, Jessica R. Sheldon, Martin J. McGavin, Patti K. Kiser, David E. Heinrichs   +11 more
doaj   +1 more source

Epigenetic Control of Cytomegalovirus Latency and Reactivation

Viruses, 2013
Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate ...
Mary Hummel, Shixian Yan, Zheng Zhang, Michael Abecassis, Xue-feng Liu, Xueqiong Wang   +5 more
doaj   +1 more source

Final report [on $gamma$-phage repressor]

, 1974
BS>Data are presented on the molecular weight of repressor proteins, DNA binding mechanisms of lambda phage repressors, and their role in the functioning of phage genes ...
Ptashne, M
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1. [PDF]

PLoS ONE, 2014
Loss of the chromatin remodeling ATPase CHD5 has been linked to the progression of neuroblastoma tumors, yet the underlying mechanisms behind the tumor suppressor role of CHD5 are unknown.
Jinhua Quan, Guillaume Adelmant, Jarrod A Marto, A Thomas Look, Timur Yusufzai   +4 more
doaj   +1 more source

Pneumococcal histidine triad proteins are regulated by the Zn(2+)-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H

, 2009
The pneumococcal histidine triad (Pht) proteins are a recently recognized family of surface proteins, comprising 4 members: PhtA, PhtB, PhtD, and PhtE. They are being promoted for inclusion in a multicomponent pneumococcal protein vaccine currently under
Sadlon, T., Cook, J., Sadlon, Tania A., Mahdi, Layla K., Ogunniyi, A., Paton, James Cleland, Cook, Jan, Paton, J., Ogunniyi, A D, Gordon, David Llewellyn, Ogunniyi, Abiodun D., Sadlon, Tania, Grabowicz, Marcin, Paton, James C., Grabowicz, M., Gordon, D., Gordon, David L., Mahdi, L.   +17 more
core   +1 more source