Results 71 to 80 of about 1,762,100 (297)
Amyloidogenesis of a Type III-dependent Hpa1 and Structural analysis of a drug-pump repressor DNA complex [PDF]
, 2010 Part I Amyloidogenesis of Type III-dependent Hpa1 from Xanthomonas oryzae pv. oryzicola The first harpin, HrpN from Erwinia amylovora, the bacterium that causes fire blight of pear, apple and other rosaceous plants, was reported as an HR ...
ZHANG, BING
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator
eLife, 2018 MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals.
Daiana A Capdevila +5 more
doaj +1 more source
A Splicing Repressor Domain in Polypyrimidine Tract-binding Protein [PDF]
Journal of Biological Chemistry, 2006 Polypyrimidine tract-binding protein (PTB) is an hnRNP with four RRM type domains. It plays roles as a repressive alternative splicing regulator of multilple target genes, as well as being involved in pre-mRNA 3' end processing, mRNA localization, stability, and internal ribosome entry site-mediated translation.
Fiona, Robinson, Christopher W J, Smith
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Unraveling Mechanisms of Transcriptional Repression: Novel Insights from Brinker [PDF]
, 2013 Transcriptional repressors bind cis-regulatory elements of target genes in a sequence specific manner. To antagonize transcription, repressors primarily function by recruiting accessory proteins, co-repressors, which in turn largely function by modifying
Upadhyai, Priyanka
core
Structural biology of Vibrio cholerae pathogenicity factors [PDF]
, 2009 The World Health Organization (WHO) states that 30,000 children under the age of five die each day worldwide. Around a quarter of these die from diarrheal disease caused by microbial infection.
Sheikh, Md. Arif
core +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Regulated expression of a repressor protein: FadR activates iclR [PDF]
Journal of Bacteriology, 1996 The control of the glyoxylate bypass operon (aceBAK) of Escherichia coli is mediated by two regulatory proteins, IclMR and FadR. IclMR is a repressor protein which has previously been shown to bind to a site which overlaps the aceBAK promoter. FAR is a repressor/activator protein which participates in control of the genes of fatty acid metabolism.
L, Gui, A, Sunnarborg, D C, LaPorte
openaire +2 more sources
Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes [PDF]
, 2010 peer-reviewedBackground: About forty human diseases are caused by repeat instability mutations. A distinct subset of these diseases is the result of extreme expansions of polymorphic trinucleotide repeats; typically CAG repeats encoding poly-glutamine ...
Herman Raadsma +30 more
core +1 more source