Results 71 to 80 of about 290,663 (301)

The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1. [PDF]

PLoS ONE, 2014
Loss of the chromatin remodeling ATPase CHD5 has been linked to the progression of neuroblastoma tumors, yet the underlying mechanisms behind the tumor suppressor role of CHD5 are unknown.
Jinhua Quan, Guillaume Adelmant, Jarrod A Marto, A Thomas Look, Timur Yusufzai   +4 more
doaj   +1 more source

A Master equation approach to modeling an artificial protein motor

, 2010
Linear bio-molecular motors move unidirectionally along a track by coordinating several different processes, such as fuel (ATP) capture, hydrolysis, conformational changes, binding and unbinding from a track, and center-of-mass diffusion.
Alberts, Allen, Astumian, Astumian, Astumian, Astumian, Balzani, Bath, Borden, Bromley, Bustamante, Carey, Craig, Eaton, Feringa, Finucane, Geertsema, Gerhard A. Blab, Greenleaf, Heiner Linke, Howard, Kay, Klok, Kottas, Magnasco, Nathan J. Kuwada, Parsons, Phillips, Schaad, Silvi, Stockley, van Delden, Vilfan, Vilfan, Wang, Yurke   +35 more
core   +1 more source

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression. [PDF]

, 2017
Distinct epigenomic profiles of histone marks have been associated with gene expression, but questions regarding the causal relationship remain. Here we investigated the activity of a broad collection of genomically targeted epigenetic regulators that ...
Farnham, Peggy J, Halmai, Julian, Le, Victoria M, Mackay, Joel P, Nicolet, Charles M, O'Geen, Henriette, Perez, Andrew A, Ren, Chonghua, Segal, David J   +8 more
core   +2 more sources

A Splicing Repressor Domain in Polypyrimidine Tract-binding Protein [PDF]

Journal of Biological Chemistry, 2006
Polypyrimidine tract-binding protein (PTB) is an hnRNP with four RRM type domains. It plays roles as a repressive alternative splicing regulator of multilple target genes, as well as being involved in pre-mRNA 3' end processing, mRNA localization, stability, and internal ribosome entry site-mediated translation.
Fiona, Robinson, Christopher W J, Smith
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

eLife, 2018
MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals.
Daiana A Capdevila, Fidel Huerta, Katherine A Edmonds, My Tra Le, Hongwei Wu, David P Giedroc   +5 more
doaj   +1 more source

Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression [PDF]

, 2006
We present an analytical framework describing the steady-state distribution of protein concentration in live cells, considering that protein production occurs in random bursts with an exponentially distributed number of molecules.
Cai, Long, Friedman, Nir, Xie, X. Sunney
core   +1 more source

Regulated expression of a repressor protein: FadR activates iclR [PDF]

Journal of Bacteriology, 1996
The control of the glyoxylate bypass operon (aceBAK) of Escherichia coli is mediated by two regulatory proteins, IclMR and FadR. IclMR is a repressor protein which has previously been shown to bind to a site which overlaps the aceBAK promoter. FAR is a repressor/activator protein which participates in control of the genes of fatty acid metabolism.
L, Gui, A, Sunnarborg, D C, LaPorte
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Proteins of the ETS family with transcriptional repressor activity [PDF]

Oncogene, 2000
ETS proteins form one of the largest families of signal-dependent transcriptional regulators, mediating cellular proliferation, differentiation and tumorigenesis. Most of the known ETS proteins have been shown to activate transcription. However, four ETS proteins (YAN, ERF, NET and TEL) can act as transcriptional repressors.
G, Mavrothalassitis, J, Ghysdael
openaire   +2 more sources