Results 71 to 80 of about 1,854,175 (305)

Structural biology of Vibrio cholerae pathogenicity factors [PDF]

, 2009
The World Health Organization (WHO) states that 30,000 children under the age of five die each day worldwide. Around a quarter of these die from diarrheal disease caused by microbial infection.
Sheikh, Md. Arif
core   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Transcriptional silencing in Saccharomyces cerevisiae: known unknowns

Epigenetics & Chromatin
Transcriptional silencing in Saccharomyces cerevisiae is a persistent and highly stable form of gene repression. It involves DNA silencers and repressor proteins that bind nucleosomes.
Namrita Dhillon, Rohinton T. Kamakaka
doaj   +1 more source

PCGF5 is required for neural differentiation of embryonic stem cells

Nature Communications, 2018
Polycomb-group proteins are key regulators of transcriptional programs that maintain cell identity. Here the authors provide evidence that PCGF5, a subunit of Polycomb Repressor Complex 1, is important for the differentiation of mouse embryonic stem ...
Mingze Yao, Xueke Zhou, Jiajian Zhou, Shixin Gong, Gongcheng Hu, Jiao Li, Kaimeng Huang, Ping Lai, Guang Shi, Andrew P. Hutchins, Hao Sun, Huating Wang, Hongjie Yao   +12 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Arabidopsis PROTEASOME REGULATOR1 is required for auxin-mediated suppression of proteasome activity and regulates auxin signalling

Nature Communications, 2016
Plant responses to auxin require proteasome-mediated degradation of Aux/IAA transcriptional repressor proteins. Here, Yang et al. show that auxin suppresses proteasome activity in a manner dependent on the proteasome regulator PTRE1 and propose a ...
Bao-Jun Yang, Xin-Xin Han, Lin-Lin Yin, Mei-Qing Xing, Zhi-Hong Xu, Hong-Wei Xue   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Engineering novel CRISPRi repressors for highly efficient mammalian gene regulation

Genome Biology
Background CRISPR interference (CRISPRi), the repurposing of the RNA-guided endonuclease dCas9 as a programmable transcriptional repressor, allows highly specific repression (knockdown) of gene expression.
Andrew Kristof, Krithika Karunakaran, Christopher Allen, Paula Mizote, Sophie Briggs, Zixin Jian, Patrick Nash, John Blazeck   +7 more
doaj   +1 more source

ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

Nature Communications, 2016
The transcription factors ZEB1 and YAP function in different pathways yet both activate aggressive behaviour in cancer cells. Here, the authors describe that the proteins physically interact and that this changes the transcriptional activity of ZEB1 from
Waltraut Lehmann, Dirk Mossmann, Julia Kleemann, Kerstin Mock, Chris Meisinger, Tilman Brummer, Ricarda Herr, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz   +9 more
doaj   +1 more source

The Transcriptional Repressor BS69 is a Conserved Target of the E1A Proteins from Several Human Adenovirus Species

Viruses, 2018
Early region 1A (E1A) is the first viral protein produced upon human adenovirus (HAdV) infection. This multifunctional protein transcriptionally activates other HAdV early genes and reprograms gene expression in host cells to support productive infection.
Ali Zhang, Tanner M. Tessier, Kristianne J. C. Galpin, Cason R. King, Steven F. Gameiro, Wyatt W. Anderson, Ahmed F. Yousef, Wen T. Qin, Shawn S. C. Li, Joe S. Mymryk   +9 more
doaj   +1 more source