Results 91 to 100 of about 1,854,175 (305)

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Nature Communications, 2019
Mutation of LMNA, encoding Lamin A/C nuclear proteins, cause dilated cardiomyopathy and conduction disorders. Here, the authors show that patient-specific iPSC-derived CMs carrying the K219T LMNA mutation have downregulated Nav1.5 channels due to dynamic
Nicolò Salvarani, Silvia Crasto, Michele Miragoli, Alessandro Bertero, Marianna Paulis, Paolo Kunderfranco, Simone Serio, Alberto Forni, Carla Lucarelli, Matteo Dal Ferro, Veronica Larcher, Gianfranco Sinagra, Paolo Vezzoni, Charles E. Murry, Giuseppe Faggian, Gianluigi Condorelli, Elisa Di Pasquale   +16 more
doaj   +1 more source

Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex

, 2008
International audienceNuclear factor 1 (NF1) binds to two upstream elements of the human adenine nucleotide translocator-2 (ANT-2) promoter and actively represses expression of the gene in growth-arrested diploid skin fibroblasts (Luciakova, Barath ...
Gabriel Kollarovic, Nelson, Buck Dean, Kollarovic, Gabriel, Luciakova, Katarina, Katarina Luciakova, Barath, Peter, Nelson, B. Dean,, B. Dean Nelson, Peter Barath   +8 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

TBLR1 regulates the expression of nuclear hormone receptor co-repressors

BMC Cell Biology, 2006
Background Transcription is regulated by a complex interaction of activators and repressors. The effectors of repression are large multimeric complexes which contain both the repressor proteins that bind to transcription factors and a number of co ...
Brown Stuart, Gu Judy, Zeng Lin, Chang Qing, Zhang Xin-Min, Basch Ross S   +5 more
doaj   +1 more source

Lactose repressor proteins with increased operator DNA binding affinity

, 2008
The present invention provides altered lac repressor proteins that recognize the lactose operator with increased affinity and have either normal or enhanced ligand responsivity.
Matthews, Kathleen S., Swint-kruse, Liskin, Foster, Catherine M.   +2 more
core  

Pumilio binds para mRNA and requires nanos and brat to regulate sodium current in drosophila motoneurons [PDF]

, 2008
Homeostatic regulation of ionic currents is of paramount importance during periods of synaptic growth or remodeling. Our previous work has identified the translational repressor Pumilio (Pum) as a regulator of sodium current (INa) and excitability in ...
Moffat, K G, Weston, Andrew J., Baines, Richard A., Gerber, Andre P., Baines, R A, Muraro, Nara I., Luschnig, Stefan, Gerber, A P, Baines, Richard A.; id_orcid, Weston, A J, Moffat, Kevin G., Muraro, N I, Luschnig, S   +12 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

σE of Streptomyces coelicolor can function both as a direct activator or repressor of transcription

Communications Biology
σ factors are considered as positive regulators of gene expression. Here we reveal the opposite, inhibitory role of these proteins. We used a combination of molecular biology methods and computational modeling to analyze the regulatory activity of the ...
Jiří Pospíšil, Marek Schwarz, Alice Ziková, Dragana Vítovská, Miluše Hradilová, Michal Kolář, Alena Křenková, Martin Hubálek, Libor Krásný, Jiří Vohradský   +9 more
doaj   +1 more source

Recognition of secretory proteins in Escherichia coli requires signals in addition to the signal sequence and slow folding

BMC Microbiology, 2002
Background The Sec-dependent protein export apparatus of Escherichia coli is very efficient at correctly identifying proteins to be exported from the cytoplasm.
Flower Ann M, Smith Margaret A, Mallik Ipsita   +2 more
doaj   +1 more source