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A Tale of Two Repressors [PDF]
Journal of Molecular Biology, 2011 Few proteins have had such a strong impact on a field, as the lac repressor and λ repressor have had in Molecular Biology in bacteria. The genes required for lactose utilization are negatively regulated; the lac repressor binds to an upstream operator blocking the transcription of the enzymes necessary for lactose utilization.
Mitchell Lewis
exaly +3 more sources
Microorganisms, 2023 Mutations leading to upregulation of efflux pumps can produce multiple drug resistance in the pathogen Pseudomonas aeruginosa. Changes in their DNA binding regions, i.e., palindromic operators, can compromise pump depression and subsequently enhance ...
María Pérez-Vázquez +6 more
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The MocR/GabR Ectoine and Hydroxyectoine Catabolism Regulator EnuR: Inducer and DNA Binding
Frontiers in Microbiology, 2021 The compatible solutes ectoine and 5-hydroxyectoine are widely synthesized by bacteria as osmostress protectants. These nitrogen-rich tetrahydropyrimidines can also be exploited as nutrients by microorganisms. Many ectoine/5-hydroxyectoine catabolic gene
Lucas Hermann +9 more
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Animals, 2023 PPARs are essential regulators of mammalian fatty acid and lipid metabolism. Although the effects of genetic variations, including single nucleotide polymorphisms (SNPs) in PPARs genes on the phenotype of domestic animals have been investigated, there is
Jia He +8 more
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Repressors of anthocyanin biosynthesis [PDF]
New Phytologist, 2021 SummaryAnthocyanins play a variety of adaptive roles in both vegetative tissues and reproductive organs of plants. The broad functionality of these compounds requires sophisticated regulation of the anthocyanin biosynthesis pathway to allow proper localization, timing, and optimal intensity of pigment deposition.
Amy M. LaFountain, Yao‐Wu Yuan
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Frontiers in Plant Science, 2021 Anthocyanins and proanthocyanidins (PAs) are important flavonoids in Chinese bayberry (Morella rubra), which functions in fruit color and exhibits multiple health promoting and disease-preventing effects.
Liyu Shi +6 more
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Conserved and Unique Functions of Blimp1 in Immune Cells
Frontiers in Immunology, 2022 B-lymphocyte-induced maturation protein-1 (Blimp1), is an evolutionarily conserved transcriptional regulator originally described as a repressor of gene transcription.
Samantha Nadeau +4 more
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Biomolecules, 2023 Saro_0803 is a transcriptional factor modulating the transcription of the stilbene-degrading enzyme gene nov1 in Novosphingobium aromaticivorans DSM 12444.
Zhen He +5 more
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Regulation of Αlpha-Synuclein Gene (SNCA) by Epigenetic Modifier TET1 in Parkinson Disease [PDF]
International Neurourology Journal, 2022 Purpose Deregulation of SNCA encoding α-synuclein (α-SYN) has been associated with both the familial and sporadic forms of Parkinson disease (PD). Epigenetic regulation plays a crucial role in PD.
Subhrangshu Guhathakurta +5 more
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Frontiers in Microbiology, 2022 Genetic alterations leading to the constitutive upregulation of specific efflux pumps contribute to antibacterial resistance in multidrug resistant bacteria.
Mireia López-Siles +2 more
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