Results 31 to 40 of about 483,350 (345)

Allelic expression mapping across cellular lineages to establish impact of non‐coding SNPs

Molecular Systems Biology, 2014
Most complex disease‐associated genetic variants are located in non‐coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis ...
Veronique Adoue, Alicia Schiavi, Nicholas Light, Jonas Carlsson Almlöf, Per Lundmark, Bing Ge, Tony Kwan, Maxime Caron, Lars Rönnblom, Chuan Wang, Shu‐Huang Chen, Alison H Goodall, Francois Cambien, Panos Deloukas, Willem H Ouwehand, Ann‐Christine Syvänen, Tomi Pastinen   +16 more
doaj   +1 more source

Ten-eleven translocation proteins (TETs): tumor suppressors or tumor enhancers?

Frontiers in Bioscience-Landmark, 2021
The epigenetic memory stored in the dynamic modifications, such as base modifications of cytosine (C) in DNA, including methylation/hydroxymethylation/demethylation, causes heritable phenotypes via regulating gene expression without alteration of DNA ...
Cuili Ma, Hwanwook Seong, Yumei Liu, Xiao Yu, Shuanliang Xu, Yujing Li   +5 more
doaj   +1 more source

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. [PDF]

, 2020
Mammalian circadian rhythms are generated by a transcription-based feedback loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2), which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24 hr periodicity ...
Abraham, Adams, Anand, Aryal, Battye, Beckett, Berendsen, Brautigam, Bussi, Czarna, Czarna, Edwards, Emsley, Evans, Fairhead, Fuxreiter, Gao, Gekakis, Griffin, Gustafson, Hirota, Hitomi, Huang, Khan, Kim, Kiyohara, Koike, Lee, Levy, Li, Lindorff-Larsen, Liu, Liu, Ludtke, López-Llano, McClendon, McGibbon, Michael, Michael, Miyazaki, Moffett, Nangle, Ode, Park, Park, Parrinello, Partch, Partch, Patke, Pettersen, Preitner, Rapp, Rosensweig, Sancar, Sato, Scheres, Schmalen, Suloway, Takahashi, Ukai-Tadenuma, van der Horst, van Zundert, Vitaterna, Voss, Wagner, Winn, Xing, Xu, Yagita, Zhang, Zhu   +70 more
core   +3 more sources

A R2R3-MYB Transcription Factor, VvMYBC2L2, Functions as a Transcriptional Repressor of Anthocyanin Biosynthesis in Grapevine (Vitis vinifera L.)

Molecules, 2018
In grapevine, the MYB transcription factors play an important role in the flavonoid pathway. Here, a R2R3-MYB transcription factor, VvMYBC2L2, isolated from Vitis vinifera cultivar Yatomi Rose, may be involved in anthocyanin biosynthesis as a ...
Ziguo Zhu, Guirong Li, Li Liu, Qingtian Zhang, Zhen Han, Xuesen Chen, Bo Li   +6 more
doaj   +1 more source

Role of the Two-Component System CiaRH in the Regulation of Efflux Pump SatAB and Its Correlation with Fluoroquinolone Susceptibility

Microbiology Spectrum, 2022
Streptococcus suis is an important pathogen in both pigs and humans. Although the diseases associated with S. suis can typically be treated with antibiotics, such use has resulted in a sustained increase in drug resistance. Bacteria can sense and respond
Xia Yang, Wei Peng, Ningning Wang, Beibei Dou, Fengming Yang, Huanchun Chen, Fangyan Yuan, Weicheng Bei   +7 more
doaj   +1 more source

The Enterococcus faecalis FabT Transcription Factor Regulates Fatty Acid Biosynthesis in Response to Exogeneous Fatty Acids

Frontiers in Microbiology, 2022
The phospholipid acyl chains of Enterococcus faecalis can be derived either by de novo synthesis or by incorporation of exogenous fatty acids through the fatty acid kinase complex (Fak)-phosphate acyltransferase (PlsX) pathway.
Qi Zou, Huijuan Dong, Lei Zhu, John E. Cronan, John E. Cronan   +4 more
doaj   +1 more source

Finding the center reliably: robust patterns of developmental gene expression

, 2005
We investigate a mechanism for the robust identification of the center of a developing biological system. We assume the existence of two morphogen gradients, an activator emanating from the anterior, and a co-repressor from the posterior.
A. Eldar, A. M. Turing, A. V. Spirov, B. Houchmandzadeh, C. Zhao, H. Meinhardt, L. Wolpert, Martin Howard, Pieter Rein ten Wolde, X. Ma   +9 more
core   +1 more source

Coarse-grained model of entropic allostery [PDF]

, 2004
Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via
A. Cooper, A. L. Lehninger, A. M. Friedman, A. M. Spiegel, B. Alberts, G. Rhodes, K. S. Matthews, L. Swint-Kruse, M. Lewis, M. Slijper, M. D. Barkley, N. Yildirim, Rhoda J. Hawkins, Tom C. B. McLeish   +13 more
core   +3 more sources

Functional Mechanism of the Efflux Pumps Transcription Regulators From Pseudomonas aeruginosa Based on 3D Structures

Frontiers in Molecular Biosciences, 2018
Bacterial antibiotic resistance is a worldwide health problem that deserves important research attention in order to develop new therapeutic strategies.
Karim Housseini B Issa, Gilles Phan, Isabelle Broutin   +2 more
doaj   +1 more source

RETRACTED: LacI-Family Transcriptional Regulator DagR Acts as a Repressor of the Agarolytic Pathway Genes in Streptomyces coelicolor A3(2)

Frontiers in Microbiology, 2021
Actinobacteria utilize various polysaccharides in the soil as carbon source by degrading them via extracellular hydrolytic enzymes. Agarose, a marine algal polysaccharide composed of D-galactose and 3,6-anhydro-L-galactose (AHG), is one of the carbon ...
Maral Tsevelkhoroloo, So Heon Shim, Chang-Ro Lee, Soon-Kwang Hong, Young-Soo Hong   +4 more
doaj   +1 more source