Results 21 to 30 of about 340,279 (315)

An enhanced CRISPR repressor for targeted mammalian gene regulation

Nature Methods, 2018
The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
N. C. Yeo, Alejandro Chavez, Alissa Lance-Byrne, Y. Chan, David J. Menn, Denitsa Milanova, Chih-Chung Kuo, Xiaoge Guo, Sumana Sharma, Angela Tung, Ryan J. Cecchi, Marcelle Tuttle, Swechchha Pradhan, Elaine T. Lim, Noah Davidsohn, M. Ebrahimkhani, J. Collins, N. Lewis, S. Kiani, G. Church   +19 more
semanticscholar   +1 more source

Repressors of reprogramming

World Journal of Stem Cells, 2015
Induced pluripotent stem cells (iPSCs) have been the focal point of ever increasing interest and scrutiny as they hold the promise of personalized regenerative medicine. However, creation of iPSCs is an inefficient process that requires forced expression of potentially oncogenic proteins.
Melissa, Popowski, Haley, Tucker
openaire   +2 more sources

The GbsR Family of Transcriptional Regulators: Functional Characterization of the OpuAR Repressor

Frontiers in Microbiology, 2018
Accumulation of compatible solutes is a common stress response of microorganisms challenged by high osmolarity; it can be achieved either through synthesis or import.
Stefanie Ronzheimer, Bianca Warmbold, Christian Arnhold, Erhard Bremer, Erhard Bremer   +4 more
doaj   +1 more source

Overexpression of PvPin1, a Bamboo Homolog of PIN1-Type Parvulin 1, Delays Flowering Time in Transgenic Arabidopsis and Rice

Frontiers in Plant Science, 2017
Because of the long and unpredictable flowering period in bamboo, the molecular mechanism of bamboo flowering is unclear. Recent study showed that Arabidopsis PIN1-type parvulin 1 (Pin1At) is an important floral activator and regulates floral transition ...
Zhigang Zheng, Xiaoming Yang, Yaping Fu, Longfei Zhu, Hantian Wei, Xinchun Lin   +5 more
doaj   +1 more source

A 314-bp SINE insertion in the ZNF2 promoter region may act as a repressor related to regulation of fat deposition in pigs

Journal of Integrative Agriculture, 2023
Retrotransposons, a type of DNA fragment that can mobilize itself on genome, can generate genetic variations and develop for molecular markers based on the insertion polymorphism.
Hao GU, Zhan-yu DU, Eduard MURANI, Enrico D'ALESSANDRO, Cai CHEN, Xiao-yan WANG, Jiu-de MAO, Klaus WIMMERS, Cheng-yi SONG   +8 more
doaj   +1 more source

Allelic expression mapping across cellular lineages to establish impact of non‐coding SNPs

Molecular Systems Biology, 2014
Most complex disease‐associated genetic variants are located in non‐coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis ...
Veronique Adoue, Alicia Schiavi, Nicholas Light, Jonas Carlsson Almlöf, Per Lundmark, Bing Ge, Tony Kwan, Maxime Caron, Lars Rönnblom, Chuan Wang, Shu‐Huang Chen, Alison H Goodall, Francois Cambien, Panos Deloukas, Willem H Ouwehand, Ann‐Christine Syvänen, Tomi Pastinen   +16 more
doaj   +1 more source

Noncoding RNA Gas5 Is a Growth Arrest and Starvation-Associated Repressor of the Glucocorticoid Receptor

Science Signaling, 2010
Gas5 is a noncoding RNA that acts as a decoy glucocorticoid response element to inhibit glucocorticoid-mediated transcription. Noncoding RNA Decoys Steroid receptors are transcription factors that are activated by ligand binding, which allows these ...
T. Kino, D. Hurt, T. Ichijo, N. Nader, G. Chrousos   +4 more
semanticscholar   +1 more source

Ten-eleven translocation proteins (TETs): tumor suppressors or tumor enhancers?

Frontiers in Bioscience-Landmark, 2021
The epigenetic memory stored in the dynamic modifications, such as base modifications of cytosine (C) in DNA, including methylation/hydroxymethylation/demethylation, causes heritable phenotypes via regulating gene expression without alteration of DNA ...
Cuili Ma, Hwanwook Seong, Yumei Liu, Xiao Yu, Shuanliang Xu, Yujing Li   +5 more
doaj   +1 more source

A R2R3-MYB Transcription Factor, VvMYBC2L2, Functions as a Transcriptional Repressor of Anthocyanin Biosynthesis in Grapevine (Vitis vinifera L.)

Molecules, 2018
In grapevine, the MYB transcription factors play an important role in the flavonoid pathway. Here, a R2R3-MYB transcription factor, VvMYBC2L2, isolated from Vitis vinifera cultivar Yatomi Rose, may be involved in anthocyanin biosynthesis as a ...
Ziguo Zhu, Guirong Li, Li Liu, Qingtian Zhang, Zhen Han, Xuesen Chen, Bo Li   +6 more
doaj   +1 more source

DWARF 53 acts as a repressor of strigolactone signalling in rice

Nature, 2013
Strigolactones (SLs) are a group of newly identified plant hormones that control plant shoot branching. SL signalling requires the hormone-dependent interaction of DWARF 14 (D14), a probable candidate SL receptor, with DWARF 3 (D3), an F-box component of
Liang Jiang, Xuejiang Liu, Guosheng Xiong, Huihui Liu, Fulu Chen, Lei Wang, Xiangbing Meng, Guifu Liu, Hong Yu, Yundong Yuan, W. Yi, Lihua Zhao, Honglei Ma, Yuanzheng He, Zhong-shan Wu, K. Melcher, Q. Qian, H. E. Xu, Yonghong Wang, Jiayang Li   +19 more
semanticscholar   +1 more source