Results 11 to 20 of about 483,350 (345)

An enhanced CRISPR repressor for targeted mammalian gene regulation [PDF]

Nature Methods, 2018
The RNA-guided endonuclease Cas9 can be converted into a programmable transcriptional repressor, but inefficiencies in target-gene silencing have limited its utility.
N. C. Yeo, Alejandro Chavez, Alissa Lance-Byrne, Y. Chan, David J. Menn, Denitsa Milanova, Chih-Chung Kuo, Xiaoge Guo, Sumana Sharma, Angela Tung, Ryan J. Cecchi, Marcelle Tuttle, Swechchha Pradhan, Elaine T. Lim, Noah Davidsohn, M. Ebrahimkhani, J. Collins, N. Lewis, S. Kiani, G. Church   +19 more
semanticscholar   +3 more sources

Concentration and Length Dependence of DNA Looping in Transcriptional Regulation [PDF]

, 2008
In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest.
Beausang, John F., Blumberg, Seth, Garcia, Hernan G., Han, Lin, Nelson, Philip C., Phillips, Rob, Towles, Kevin B.   +6 more
core   +13 more sources

Rules of Expansion: an Updated Consensus Operator Site for the CopR-CopY Family of Bacterial Copper Exporter System Repressors

mSphere, 2020
Copper is broadly toxic to bacteria. As such, bacteria have evolved specialized copper export systems (cop operons) often consisting of a DNA-binding/copper-responsive regulator (which can be a repressor or activator), a copper chaperone, and a copper ...
Henrik O’Brien, Joseph W. Alvin, Sanjay V. Menghani, Yamil Sanchez-Rosario, Koenraad Van Doorslaer, Michael D. L. Johnson   +5 more
doaj   +1 more source

Two Retrotransposon Elements in Intron of Porcine BMPR1B Is Associated with Phenotypic Variation

Life, 2022
It has been established that through binding to bone morphogenetic proteins (BMPs), bone morphogenetic protein receptor I B (BMPR1B) can mediate transforming growth factor β (TGF-β) signal transduction, and is involved in the regulation of several ...
Chenglin Chi, Jia He, Zhanyu Du, Yao Zheng, Enrico D’Alessandro, Cai Chen, Ali Shoaib Moawad, Emmanuel Asare, Chengyi Song, Xiaoyan Wang   +9 more
doaj   +1 more source

Genome-Wide Characterization of R2R3-MYB Transcription Factors in Pitaya Reveals a R2R3-MYB Repressor HuMYB1 Involved in Fruit Ripening through Regulation of Betalain Biosynthesis by Repressing Betalain Biosynthesis-Related Genes

Cells, 2021
The MYB (myeloblastosis) superfamily constitutes one of the most abundant transcription factors (TFs) regulating various biological processes in plants. However, the molecular characteristics and functions of MYB TFs in pitaya remain unclear. To date, no
Fangfang Xie, Qingzhu Hua, Canbin Chen, Zhike Zhang, Rong Zhang, Jietang Zhao, Guibing Hu, Jianye Chen, Yonghua Qin   +8 more
doaj   +1 more source

CrgA Protein Represses AlkB2 Monooxygenase and Regulates the Degradation of Medium-to-Long-Chain n-Alkanes in Pseudomonas aeruginosa SJTD-1

Frontiers in Microbiology, 2019
AlkB monooxygenases in bacteria are responsible for the hydroxylation of medium- and long-chain n-alkanes. In this study, one CrgA protein of Pseudomonas aeruginosa SJTD-1, a member of LysR family, was proved to regulate AlkB2 monooxygenase and the ...
Nannan Ji, Xiuli Wang, Chong Yin, Wanli Peng, Rubing Liang   +4 more
doaj   +1 more source

The KRAB Domain‐Containing Protein ZFP961 Represses Adipose Thermogenesis and Energy Expenditure through Interaction with PPARα

Advanced Science, 2022
Adipose thermogenesis plays a pivotal role in whole‐body metabolic homeostasis. Although transcriptional mechanisms that promote thermogenesis are extensively studied, the negative regulatory network is still poorly understood. Here, a Krüppel‐associated
Lei Huang, Pengpeng Liu, Qiyuan Yang, Yong‐Xu Wang   +3 more
doaj   +1 more source

The Transcription Repressor REST in Adult Neurons: Physiology, Pathology, and Diseases,,

eNeuro, 2015
REST [RE1-silencing transcription factor (also called neuron-restrictive silencer factor)] is known to repress thousands of possible target genes, many of which are neuron specific.
P. Baldelli, J. Meldolesi
semanticscholar   +1 more source

Profiling of REST-dependent microRNAs reveals dynamic modes of expression

Frontiers in Neuroscience, 2012
Multipotent neural stem cells (NSCs) possess the ability to self-renew and differentiate into both neurons and glia. However, the detailed mechanisms underlying NSC fate decisions are not well understood.
Zhengliang eGao, Peiguo eDing, Jenny eHsieh   +2 more
doaj   +1 more source

A Gain-of-Function Mutant of IAA15 Inhibits Lateral Root Development by Transcriptional Repression of LBD Genes in Arabidopsis

Frontiers in Plant Science, 2020
Lateral root development is known to be regulated by Aux/IAA-ARF modules in Arabidopsisthaliana. As components, several Aux/IAAs have participated in these Aux/IAA-ARF modules.
Sun Ho Kim, Sunghwa Bahk, Jonguk An, Shah Hussain, Nhan Thi Nguyen, Huy Loc Do, Jae-Yean Kim, Jong Chan Hong, Woo Sik Chung   +8 more
doaj   +1 more source