Results 11 to 20 of about 264,694 (307)

Rules of Expansion: an Updated Consensus Operator Site for the CopR-CopY Family of Bacterial Copper Exporter System Repressors

open access: yesmSphere, 2020
Copper is broadly toxic to bacteria. As such, bacteria have evolved specialized copper export systems (cop operons) often consisting of a DNA-binding/copper-responsive regulator (which can be a repressor or activator), a copper chaperone, and a copper ...
Henrik O’Brien   +5 more
doaj   +1 more source

The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Caffeine and Istradefylline [PDF]

open access: yes, 2021
The orphan nuclear receptor TLX is expressed almost exclusively in neural stem cells. TLX acts as an essential factor for neural stem cell survival and is hence considered as a promising drug target in neurodegeneration.
Pascal, Heitel   +10 more
core   +2 more sources

Two Retrotransposon Elements in Intron of Porcine BMPR1B Is Associated with Phenotypic Variation

open access: yesLife, 2022
It has been established that through binding to bone morphogenetic proteins (BMPs), bone morphogenetic protein receptor I B (BMPR1B) can mediate transforming growth factor β (TGF-β) signal transduction, and is involved in the regulation of several ...
Chenglin Chi   +9 more
doaj   +1 more source

Genome-Wide Characterization of R2R3-MYB Transcription Factors in Pitaya Reveals a R2R3-MYB Repressor HuMYB1 Involved in Fruit Ripening through Regulation of Betalain Biosynthesis by Repressing Betalain Biosynthesis-Related Genes

open access: yesCells, 2021
The MYB (myeloblastosis) superfamily constitutes one of the most abundant transcription factors (TFs) regulating various biological processes in plants. However, the molecular characteristics and functions of MYB TFs in pitaya remain unclear. To date, no
Fangfang Xie   +8 more
doaj   +1 more source

CrgA Protein Represses AlkB2 Monooxygenase and Regulates the Degradation of Medium-to-Long-Chain n-Alkanes in Pseudomonas aeruginosa SJTD-1

open access: yesFrontiers in Microbiology, 2019
AlkB monooxygenases in bacteria are responsible for the hydroxylation of medium- and long-chain n-alkanes. In this study, one CrgA protein of Pseudomonas aeruginosa SJTD-1, a member of LysR family, was proved to regulate AlkB2 monooxygenase and the ...
Nannan Ji   +4 more
doaj   +1 more source

Repressor of Phage 16-3 with Altered Binding Specificity Indicates Spatial Differences in Repressor-Operator Complexes [PDF]

open access: yes, 2006
The C repressor protein of phage 16-3, which is required for establishing and maintaining lysogeny, recognizes structurally different operators which differ by 2 bp in the length of the spacer between the conserved palindromic sequences.
Papp, P. Péter   +2 more
core   +1 more source

Kaiso is a genome-wide repressor of transcription that is essential for amphibian development [PDF]

open access: yes, 2004
DNA methylation in animals is thought to repress transcription via methyl-CpG specific binding proteins, which recruit enzymatic machinery promoting the formation of inactive chromatin at targeted loci.
Richard R. Meehan   +13 more
core   +1 more source

The KRAB Domain‐Containing Protein ZFP961 Represses Adipose Thermogenesis and Energy Expenditure through Interaction with PPARα

open access: yesAdvanced Science, 2022
Adipose thermogenesis plays a pivotal role in whole‐body metabolic homeostasis. Although transcriptional mechanisms that promote thermogenesis are extensively studied, the negative regulatory network is still poorly understood. Here, a Krüppel‐associated
Lei Huang   +3 more
doaj   +1 more source

Role of the purine repressor hinge sequence in repressor function [PDF]

open access: yesJournal of Bacteriology, 1994
A protease-hypersensitive hinge sequence in Escherichia coli purine repressor (PurR) connects an N-terminal DNA-binding domain with a contiguous corepressor-binding domain. Binding of one molecule of dimeric repressor to operator DNA protects the hinge against proteolytic cleavage.
K Y, Choi, H, Zalkin
openaire   +2 more sources

The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate: sugar phosphotransferase system (PTS) in Corynebacterium glutamicum [PDF]

open access: yes, 2007
Gaigalat L, Schlüter J-P, Hartmann M, et al. The DeoR-type transcriptional regulator SugR acts as a repressor for genes encoding the phosphoenolpyruvate: sugar phosphotransferase system (PTS) in Corynebacterium glutamicum. BMC Molecular Biology. 2007;8(1)
Mormann, Sascha   +14 more
core   +1 more source

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