Results 61 to 70 of about 201,151 (364)

Auxin-sensitive Aux/IAA proteins mediate drought tolerance in Arabidopsis by regulating glucosinolate levels

Nature Communications, 2019
Brassicaceae produce glucosinolates to protect against herbivory and pathogens. Here the authors show that auxin-sensitive Aux/IAA repressor proteins regulate aliphatic glucosinolate levels in Arabidopsis and this promotes stomatal closure via reactive ...
Mohammad Salehin, Baohua Li, Michelle Tang, Ella Katz, Liang Song, Joseph R. Ecker, Daniel J. Kliebenstein, Mark Estelle   +7 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Nature Communications, 2019
PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins ...
Mariya I. Goncheva, Ronald S. Flannagan, Brigid E. Sterling, Holly A. Laakso, Nancy C. Friedrich, Julienne C. Kaiser, David W. Watson, Christy H. Wilson, Jessica R. Sheldon, Martin J. McGavin, Patti K. Kiser, David E. Heinrichs   +11 more
doaj   +1 more source

The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1. [PDF]

PLoS ONE, 2014
Loss of the chromatin remodeling ATPase CHD5 has been linked to the progression of neuroblastoma tumors, yet the underlying mechanisms behind the tumor suppressor role of CHD5 are unknown.
Jinhua Quan, Guillaume Adelmant, Jarrod A Marto, A Thomas Look, Timur Yusufzai   +4 more
doaj   +1 more source

Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins

, 2006
BACKGROUND: CtBP1 and CtBP2 are transcriptional co-repressors that modulate the activity of a large number of transcriptional repressors via the recruitment of chromatin modifiers.
Bergman, Lee M., Jeremy P Blaydes, Mirnezami Alexander H, Alexander H Mirnezami, Bergman Lee M, Samal C Gunatilake, Mirnezami, Alexander H., Darley Matthew, Morris Laila, Lee M Bergman, Laila Morris, Darley, Matthew, Gunatilake, Samal C., Blaydes, Jeremy P., Morris, Laila, Matthew Darley, Gunatilake Samal C, Blaydes Jeremy P   +17 more
core   +1 more source

Regulated expression of a repressor protein: FadR activates iclR [PDF]

Journal of Bacteriology, 1996
The control of the glyoxylate bypass operon (aceBAK) of Escherichia coli is mediated by two regulatory proteins, IclMR and FadR. IclMR is a repressor protein which has previously been shown to bind to a site which overlaps the aceBAK promoter. FAR is a repressor/activator protein which participates in control of the genes of fatty acid metabolism.
L, Gui, A, Sunnarborg, D C, LaPorte
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Epigenetic Control of Cytomegalovirus Latency and Reactivation

Viruses, 2013
Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate ...
Mary Hummel, Shixian Yan, Zheng Zhang, Michael Abecassis, Xue-feng Liu, Xueqiong Wang   +5 more
doaj   +1 more source

Unraveling Mechanisms of Transcriptional Repression: Novel Insights from Brinker [PDF]

, 2013
Transcriptional repressors bind cis-regulatory elements of target genes in a sequence specific manner. To antagonize transcription, repressors primarily function by recruiting accessory proteins, co-repressors, which in turn largely function by modifying
Upadhyai, Priyanka
core  

The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster

, 2008
The regulatory protein NsrR, a member of the Rrf2 family of transcription repressors, is specifically dedicated to sensing nitric oxide (NO) in a variety of pathogenic and non-pathogenic bacteria.
Dixon, Ray, Tucker, Nick, Ray Dixon, Govind Chandra, Chandra, Govinda, Thomas A Clarke, Clarke, Thomas A., Jason C Crack, Matthew G Hicks, Le Brun, Nick E., Nicholas P Tucker, Nick E Le Brun, Tucker, Nicholas P., Crack, Jason C., Chandra, Govind, Hutchings, Matthew I., Hicks, Matthew G., Matthew I Hutchings   +17 more
core   +1 more source