Results 61 to 70 of about 290,663 (301)

Sequence Dependence of Transcription Factor-Mediated DNA Looping [PDF]

, 2012
DNA is subject to large deformations in a wide range of biological processes. Two key examples illustrate how such deformations influence the readout of the genetic information: the sequestering of eukaryotic genes by nucleosomes, and DNA looping in ...
Barry, Bellomy, Bellomy, Brenowitz, Butler, Chen, Chen, Cloutier, Cloutier, Drew, Du, Echols, Edelman, Finzi, Frank, Garcia, Geggier, Han, Hirsh, Hogan, Hsieh, Jacobson, Krämer, Lewis, Lowary, Luger, Luijsterburg, Martin Lindén, Matthews, Mehta, Milstein, Morgan, Müller, Newman, Normanno, Oehler, Olson, Peters, Plischke, Ptashne, Rippe, Rob Phillips, Rutkauskas, Saiz, Schafer, Schleif, Segall, Shimada, Stephanie Johnson, Swigon, Tolhuis, Towles, Vanzi, Villa, Watson, Whitson, Whitson, Widom, Wong, Xu, Yin, Zhan, Zhang   +62 more
core   +4 more sources

Chemical synthesis of a fully active transcriptional repressor protein. [PDF]

Proceedings of the National Academy of Sciences, 1994
Plasmid pLS1-encoded 45-amino acid transcriptional repressor CopG (formerly RepA) has been chemically synthesized. A one-step purification of the synthetic protein has been developed, which yields high levels of pure protein with low or no contamination of truncated products.
Solar, Gloria del, Albericio, Fernando, Eritja Casadellà, Ramón, Espinosa, Manuel   +3 more
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Auxin-sensitive Aux/IAA proteins mediate drought tolerance in Arabidopsis by regulating glucosinolate levels

Nature Communications, 2019
Brassicaceae produce glucosinolates to protect against herbivory and pathogens. Here the authors show that auxin-sensitive Aux/IAA repressor proteins regulate aliphatic glucosinolate levels in Arabidopsis and this promotes stomatal closure via reactive ...
Mohammad Salehin, Baohua Li, Michelle Tang, Ella Katz, Liang Song, Joseph R. Ecker, Daniel J. Kliebenstein, Mark Estelle   +7 more
doaj   +1 more source

A role for SUMO modification in transcriptional repression and activation [PDF]

, 2007
Since the discovery of the SUMO (small ubiquitin-like modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
David, Gill, Gomez-del Arco, Gostissa, Hong, I. Stancheva, Ichimura, Kirsh, Klose, Lin, Ling, Lyst, M.J. Lyst, Nathan, Nishida, Rodriguez, Shiio, Shin, Sterner, Uchimura, Verger, Yamaguchi, Yamamoto, Yang, Yang, Yang, Yang   +26 more
core   +1 more source

The c1 repressor of bacteriophage P1. Isolation and characterization of the repressor protein.

Journal of Biological Chemistry, 1988
The c1 repressor gene of bacteriophage P1 is located on P1 DNA EcoRI fragment 7 (Sternberg, N. (1979) Virology 96, 129-142). Subfragments of P1 DNA EcoRI fragment 7 were cloned into expression vectors, and the c1 repressor protein from P1 wild-type phage and a revertant of a temperature-sensitive repressor mutant were overproduced in Escherichia coli ...
B, Dreiseikelmann, M, Velleman, H, Schuster   +2 more
openaire   +2 more sources

The transcriptional repressor protein PRH interacts with the proteasome [PDF]

Biochemical Journal, 2003
PRH (proline-rich homeodomain protein)/Hex is important in the control of cell proliferation and differentiation. We have shown previously that PRH contains two domains that can bring about transcriptional repression independently; the PRH homeodomain represses transcription by binding to TATA box sequences, whereas the proline-rich N-terminal domain ...
Bess, KL, Swingler, TE, Rivett, AJ, Gaston, K, Jayaraman, P-S   +4 more
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Nature Communications, 2019
PurR acts as transcriptional repressor of purine biosynthesis genes in some bacterial species. Here, the authors show that purR mutations can arise in Staphylococcus aureus upon exposure to stress, leading to upregulation of fibronectin-binding proteins ...
Mariya I. Goncheva, Ronald S. Flannagan, Brigid E. Sterling, Holly A. Laakso, Nancy C. Friedrich, Julienne C. Kaiser, David W. Watson, Christy H. Wilson, Jessica R. Sheldon, Martin J. McGavin, Patti K. Kiser, David E. Heinrichs   +11 more
doaj   +1 more source

Epigenetic Control of Cytomegalovirus Latency and Reactivation

Viruses, 2013
Cytomegalovirus (CMV) gene expression is repressed in latency due to heterochromatinization of viral genomes. In murine CMV (MCMV) latently infected mice, viral genomes are bound to histones with heterochromatic modifications, to enzymes that mediate ...
Mary Hummel, Shixian Yan, Zheng Zhang, Michael Abecassis, Xue-feng Liu, Xueqiong Wang   +5 more
doaj   +1 more source