Results 51 to 60 of about 1,609 (154)

Distinct regulation of Maf1 for lifespan extension by Protein kinase A and Sch9

Aging, 2015
The Protein kinase A (PKA) and Sch9 regulates cell growth as well as lifespan in Saccharomyces cerevisiae. Maf1 is a RNA polymerase III (PolIII) inhibitor that tailors 5S rRNA and tRNA production in response to various environmental cues. Both PKA and Sch9 have been shown to phosphorylate Maf1 in vitro at similar amino acids, suggesting a redundancy in
Ying, Cai, Yue-Hua, Wei
openaire   +2 more sources

RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification.

PLoS Genetics, 2015
Control of the differential abundance or activity of tRNAs can be important determinants of gene regulation. RNA polymerase (RNAP) III synthesizes all tRNAs in eukaryotes and it derepression is associated with cancer.
Aneeshkumar G Arimbasseri, Nathan H Blewett, James R Iben, Tek N Lamichhane, Vera Cherkasova, Markus Hafner, Richard J Maraia   +6 more
doaj   +1 more source

Metabolic Reprogramming and Exosome Remodeling in an Ndufs4‐Deficient Model of Leigh Syndrome

iNew Medicine, Volume 2, Issue 2, June 2026.
Ndufs4 knockout drives exosomal remodeling, reprograms cellular metabolism, impairs neural stem cell self‐renewal and differentiation, and suppresses mTOR signaling, providing a conceptual framework for understanding Leigh syndrome pathogenesis and informing therapeutic development.
Yakun Liu, Zhi Yang, Zhencai Xing, Rongrong Zhao, Yixuan Zhou, Xue Yang, Jicheng Zhu, Shuo Chen, Yuhang Zhang, Mengxue Xu, Xiang Kong, Minqiong Sun, Zhenya Tan, Hong Zheng   +13 more
wiley   +1 more source

Polymerase II–Associated Factor 1 Complex-Regulated FLOWERING LOCUS C-Clade Genes Repress Flowering in Response to Chilling

Frontiers in Plant Science, 2022
RNA polymerase II–associated factor 1 complex (PAF1C) regulates the transition from the vegetative to the reproductive phase primarily by modulating the expression of FLOWERING LOCUS C (FLC) and FLOWERING LOCUS M [FLM, also known as MADS AFFECTING ...
Zeeshan Nasim, Hendry Susila, Suhyun Jin, Geummin Youn, Ji Hoon Ahn   +4 more
doaj   +1 more source

Phloem Proteomics to Identify Small Open Reading Frame (sORF)‐encoded Peptides With a Putative Role in the Control of Flowering Time in Arabidopsis

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phloem sap proteomic studies have previously revealed that phloem sap composition varies during development and upon floral induction. Specific proteins, lipids, messenger RNAs (mRNAs), and peptides have been shown to accumulate at different developmental stages.
Irene Moreno‐Sanguino, Lucía Argente Collás, Göran Samuelsson, Gunnar Wingsle, Reyes Benlloch   +4 more
wiley   +1 more source

Vocalization Characteristics of the Indo‐Pacific Humpback Dolphins (Sousa chinensis) in Xiamen Bay With Insights on Regional Differences

Ecology and Evolution, Volume 16, Issue 2, February 2026.
The Indo‐Pacific humpback dolphin population in Xiamen Bay was divided into two geographically separated but socially associated communities inhabiting the West and East sub‐regions. Based on 3 years of boat‐based surveys, this study established baseline acoustic characteristics and investigated whether vocal patterns varied with habitat conditions ...
Xuming Peng, Zhiyuan Hua, Fuxing Wu, Fei Zhang, Weijie Fu, Yupeng Li, Chuang Zhang, Wenzhan Ou, Wenjie Xiang, Bing Zhou, Zhongchang Song, Yu Zhang   +11 more
wiley   +1 more source

Global transcriptome profiling reveals genes responding to overproduction of a small secretory, a high cysteine- and a high glycosylation-bearing protein in Yarrowia lipolytica

Biotechnology Reports, 2021
Investigation of the yeast cell’s response to recombinant secretory protein (rs-Prot) overproduction is relevant for both basic and applied research. Imbalance, overloading or stress within this process impacts the whole cell.
Paulina Korpys-Woźniak, Ewelina Celińska   +1 more
doaj   +1 more source

Multiobjective Optimization for Torsional Stiffness of Antiroll Bar on Trucks

Shock and Vibration, Volume 2026, Issue 1, 2026.
The antiroll bar (ARB) plays an important role in reducing the rollover phenomenon and uneven load distribution between the wheels on an axle, thus enhancing the safety and roll stability of vehicles. This study proposes a method for optimizing the torsional stiffness of the ARB on trucks, with three main objectives: (1) building a general model of a ...
Ngo Van Dung, Van Tan Vu, Truong Manh Hung, Do Trong Tu, Marco Civera   +4 more
wiley   +1 more source

Physiological Roles for mafr-1 in Reproduction and Lipid Homeostasis

Cell Reports, 2014
Maf1 is a conserved repressor of RNA polymerase (Pol) III transcription; however, its physiological role in the context of a multicellular organism is not well understood. Here, we show that C.
Akshat Khanna, Deborah L. Johnson, Sean P. Curran   +2 more
doaj   +1 more source

Evaluating the Negative‐Strand Coding Potential in Plum Pox Virus

Molecular Plant Pathology, Volume 26, Issue 12, December 2025.
Plum pox virus produces two polyproteins from ORFs in the positive strand. This study explores the possible expression of peptides from negative‐strand ORFs (rORFs). ABSTRACT Recent studies proposed that the negative strands of some single‐stranded, positive‐sense RNA viruses contain reverse open reading frames (rORFs) that encode functional peptides ...
Beatriz García, José Vicente Del Álamo, Mario Rincón, Irene Gonzalo, Xiaofei Cheng, Juan Antonio García, Carmen Simón‐Mateo, Adrián A. Valli, Bernardo Rodamilans   +8 more
wiley   +1 more source