Results 21 to 30 of about 340,586 (247)
Involvement of RNA Polymerase III in Immune Responses [PDF]
Molecular and Cellular Biology, 2015 Inflammation in the tumor microenvironment has many tumor-promoting effects. In particular, tumor-associated macrophages (TAMs) produce many cytokines which can support tumor growth by promoting survival of malignant cells, angiogenesis, and metastasis. Enhanced cytokine production by TAMs is tightly coupled with protein synthesis. In turn, translation
Graczyk, Damian +2 more
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Facilitated Recycling Pathway for RNA Polymerase III [PDF]
Cell, 1996 We show that the high in vitro transcription efficiency of yeast RNA pol III is mainly due to rapid recycling. Kinetic analysis shows that RNA polymerase recycling on preassembled tDNA.TFIIIC.TFIIIB complexes is much faster than the initial transcription cycle.
DIECI, Giorgio, SENTENAC A.
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Chromatin remodeling by Pol II primes efficient Pol III transcription
Nature Communications, 2023 The packaging of the genetic material into chromatin imposes the remodeling of this barrier to allow efficient transcription. RNA polymerase II activity is coupled with several histone modification complexes that enforce remodeling.
Carlo Yague-Sanz +6 more
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Dystonia in RNA Polymerase III‐Related Leukodystrophy [PDF]
Movement Disorders Clinical Practice, 2019 AbstractObjectivesTo identify the prevalence of dystonia in a RNA Polymerase III (POLR3)‐related leukodystrophy patient cohort and to further characterize their dystonic features.BackgroundPOLR3‐related leukodystrophy is a hypomyelinating leukodystrophy characterized by neurological and non‐neurological features.
Al Yazidi, Ghalia +7 more
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A direct role of RNA polymerase III and RNA in DNA homologous recombination
Molecular & Cellular Oncology, 2021 End resection excises several thousand bases from the 5ʹ-ended strand during DNA double-strand break repair, creating 3ʹ-end single-stranded DNA overhangs. This overhang requires strict protection from DNA2 or other nucleases digestion.
Sijie Liu, Daochun Kong
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The choreography of chromatin in RNA polymerase III regulation. [PDF]
Biochem Soc TransRegulation of eukaryotic gene expression involves a dynamic interplay between the core transcriptional machinery, transcription factors, and chromatin organization and modification. While this applies to transcription by all RNA polymerase complexes, RNA polymerase III (RNAPIII) seems to be atypical with respect to its mechanisms of regulation.
van Breugel ME, Gerber A, van Leeuwen F.
europepmc +5 more sources
In vitro Assessment of RNA Polymerase I Activity
Bio-Protocol, 2017 In eukaryotic cells transcriptional processes are carried out by three different RNA polymerases: RNA polymerase I which specifically transcribes ribosomal RNA (rRNA), RNA polymerase II which transcribes protein-coding genes to yield messenger RNAs ...
Marzia Govoni
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Frontiers in Cellular and Infection Microbiology, 2022 Ancestral RNA polymerase III (Pol III) is a multi-subunit polymerase responsible for transcription of short non-coding RNA, such as double-stranded short interspersed nuclear elements (SINEs).
Brianna M. Doratt +8 more
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Specific Features of RNA Polymerases I and III: Structure and Assembly
Frontiers in Molecular Biosciences, 2021 RNA polymerase I (RNAPI) and RNAPIII are multi-heterogenic protein complexes that specialize in the transcription of highly abundant non-coding RNAs, such as ribosomal RNA (rRNA) and transfer RNA (tRNA).
Tomasz W. Turowski +2 more
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Truncated PARP1 mediates ADP-ribosylation of RNA polymerase III for apoptosis
Cell Discovery, 2022 Caspase-mediated cleavage of PARP1 is a surrogate marker for apoptosis. However, the biological significance of PARP1 cleavage during apoptosis is still unclear.
Qian Chen +7 more
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