Results 1 to 10 of about 92,028 (242)
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]
eLife, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Matthew T Parker +8 more
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Transcriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells [PDF]
VirusesHuman T-lymphotropic virus type 1 (HTLV-1), the first human retrovirus identified, is linked to adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis.
Shuanglong Wei +8 more
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Family C of Short Interspersed Elements in the Genomes of Lagomorphs: Structure, Evolution, Transcription and Transcript Polyadenylation [PDF]
AnimalsShort Interspersed Elements (SINEs) are eukaryotic non-autonomous retrotransposons that rely on RNA polymerase III (pol III) for transcription. A subset of mammalian SINEs—designated T+ SINEs—harbors a canonical polyadenylation signal (AATAAA), a pol III
Ilia G. Ustyantsev +4 more
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Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation [PDF]
Cell, 2010 The emerging discoveries on the link between polyadenylation and disease states underline the need to fully characterize genome-wide polyadenylation states. Here, we report comprehensive maps of global polyadenylation events in human and yeast generated using refinements to the Direct RNA Sequencing technology.
Philipp Kapranov +2 more
exaly +4 more sources
Advanced Science, 2021 The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai +11 more
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Insects, 2022 During the messenger RNA (mRNA) maturation process, RNA polyadenylation is a key step, and is coupled to the termination of transcription. Various cis-acting elements near the cleavage site and their binding factors would affect the process of ...
Liying Fang +4 more
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Alternative Polyadenylation Blooms [PDF]
Developmental Cell, 2010 Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
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Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements. [PDF]
Genes & Development, 1994 In the cytoplasm of oocytes and early embryos, addition of poly(A) to mRNAs can activate their translation. We demonstrate that despite many differences between poly(A) addition in the cytoplasm and nucleus, these two forms of polyadenylation may involve identical trans-acting factors.
A, Bilger +3 more
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Frontiers in Cell and Developmental Biology, 2020 In mammalian species, both the maturation promoting factor (MPF) and the mitogen-activated protein kinase (MAPK) cascade play critical roles in modulating oocyte meiotic cell-cycle progression. MPF is a critical heterodimer composed of CDK1 and cyclin B1.
Lan-Rui Cao, Jun-Chao Jiang, Heng-Yu Fan
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Frontiers in Immunology, 2022 Better methods to interrogate host-pathogen interactions during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections are imperative to help understand and prevent this disease.
Jessie J.-Y. Chang +15 more
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