Results 21 to 30 of about 66,094 (222)
To polyadenylate or to deadenylate [PDF]
Cell Cycle, 2010 mRNA polyadenylation and deadenylation are important processes that allow rapid regulation of gene expression in response to different cellular conditions. Almost all eukaryotic mRNA precursors undergo a co-transcriptional cleavage followed by polyadenylation at the 3' end.
Xiaokan, Zhang +2 more
openaire +2 more sources
eLife, 2020 Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Matthew T Parker +8 more
doaj +1 more source
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
Cell Reports, 2021 Summary: Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals mineralize.
Olga Gewartowska +16 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 In mammalian species, both the maturation promoting factor (MPF) and the mitogen-activated protein kinase (MAPK) cascade play critical roles in modulating oocyte meiotic cell-cycle progression. MPF is a critical heterodimer composed of CDK1 and cyclin B1.
Lan-Rui Cao, Jun-Chao Jiang, Heng-Yu Fan
doaj +1 more source
A novel cause of DKC1‐related bone marrow failure: Partial deletion of the 3′ untranslated region
eJHaem, 2021 Telomere biology disorders (TBDs), including dyskeratosis congenita (DC), are a group of rare inherited diseases characterized by very short telomeres. Mutations in the components of the enzyme telomerase can lead to insufficient telomere maintenance in ...
Jonathan W. Arthur +14 more
doaj +1 more source
Template-switching artifacts resemble alternative polyadenylation
BMC Genomics, 2019 Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally ...
Zsolt Balázs +5 more
doaj +1 more source
The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation [PDF]
, 2003 Cleavage and polyadenylation factor (CPF) is a multi-protein complex that functions in pre-mRNA 3'-end formation and in the RNA polymerase II (RNAP II) transcription cycle.
Sadowski, Martin +7 more
core +2 more sources
Virology Journal, 2019 Background Polyadenylation influences many aspects of mRNA as well as viral RNA. variable polyadenylation at the 3' end have been reported in RNA viruses.
Guowei Geng +3 more
doaj +1 more source
Differential polyadenylation of ribosomal RNA during post-transcriptional processing in Leishmania. [PDF]
, 2005 The protozoan parasite Leishmania belongs to the most ancient eukaryotic lineages and this is reflected in several distinctive biological features, such as eukaryotic polycistronic transcription and RNA trans-splicing.
Laurent, T. +31 more
core +1 more source
Intragenic CpG Islands and Their Impact on Gene Regulation
Frontiers in Cell and Developmental Biology, 2022 The mammalian genome is depleted in CG dinucleotides, except at protected regions where they cluster as CpG islands (CGIs). CGIs are gene regulatory hubs and serve as transcription initiation sites and are as expected, associated with gene promoters ...
James A. Cain +2 more
doaj +1 more source