Results 11 to 20 of about 62,357 (236)
Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33 [PDF]
Genes & Development, 2014 Cleavage and polyadenylation specificity factor (CPSF) is the central component of the 3′ processing machinery for polyadenylated mRNAs in metazoans: CPSF recognizes the polyadenylation signal AAUAAA, providing sequence specificity in both pre-mRNA cleavage and polyadenylation, and catalyzes pre-mRNA cleavage.
Schönemann, Lars +7 more
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Alternative Polyadenylation Blooms [PDF]
Developmental Cell, 2010 Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
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Inference of the human polyadenylation code [PDF]
Bioinformatics, 2017 Abstract Motivation Processing of transcripts at the 3′-end involves cleavage at a polyadenylation site followed by the addition of a poly(A)-tail. By selecting which site is cleaved, the process of alternative polyadenylation enables genes to produce transcript isoforms with different 3′-ends.
Leung, Michael K. K. +2 more
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Family C of Short Interspersed Elements in the Genomes of Lagomorphs: Structure, Evolution, Transcription and Transcript Polyadenylation [PDF]
AnimalsShort Interspersed Elements (SINEs) are eukaryotic non-autonomous retrotransposons that rely on RNA polymerase III (pol III) for transcription. A subset of mammalian SINEs—designated T+ SINEs—harbors a canonical polyadenylation signal (AATAAA), a pol III
Ilia G. Ustyantsev +4 more
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Alterations in polyadenylation and its implications for endocrine disease
Frontiers in Endocrinology, 2013 IntroductionPolyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation.
Anders eRehfeld +3 more
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mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases
Genes and Diseases, 2023 The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase, poly(A)
Siyao Guo, Shuibin Lin
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Transcriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells [PDF]
VirusesHuman T-lymphotropic virus type 1 (HTLV-1), the first human retrovirus identified, is linked to adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis.
Shuanglong Wei +8 more
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Alternative Polyadenylation in Human Diseases
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3'-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing. It is prevalent through all eukaryotes and has emerged as a key mechanism for controlling gene expression.
Jae-Woong Chang +2 more
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To polyadenylate or to deadenylate [PDF]
Cell Cycle, 2010 mRNA polyadenylation and deadenylation are important processes that allow rapid regulation of gene expression in response to different cellular conditions. Almost all eukaryotic mRNA precursors undergo a co-transcriptional cleavage followed by polyadenylation at the 3' end.
Xiaokan, Zhang +2 more
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Advanced Science, 2021 The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai +11 more
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