Results 11 to 20 of about 66,094 (222)

Plant polyadenylation factors: conservation and variety in the polyadenylation complex in plants [PDF]

BMC Genomics, 2012
Background Polyadenylation, an essential step in eukaryotic gene expression, requires both cis-elements and a plethora of trans-acting polyadenylation factors. The polyadenylation factors are largely conserved across mammals and fungi.
Hunt Arthur G, Xing Denghui, Li Qingshun Q   +2 more
doaj   +8 more sources

Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33 [PDF]

Genes & Development, 2014
Cleavage and polyadenylation specificity factor (CPSF) is the central component of the 3′ processing machinery for polyadenylated mRNAs in metazoans: CPSF recognizes the polyadenylation signal AAUAAA, providing sequence specificity in both pre-mRNA cleavage and polyadenylation, and catalyzes pre-mRNA cleavage.
Schönemann, Lars, Kühn, Uwe, Martin, Georges, Schäfer, Peter, Gruber, Andreas R., Keller, Walter, Zavolan, Mihaela, Wahle, Elmar   +7 more
openaire   +6 more sources

Hyperosmotic stress-induced redistribution of pre-mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation. [PDF]

FEBS Open Bio
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Soumiya H, Osawa M, Fukumitsu H.
europepmc   +2 more sources

Alternative Polyadenylation Blooms [PDF]

Developmental Cell, 2010
Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
openaire   +4 more sources

Inference of the human polyadenylation code [PDF]

Bioinformatics, 2017
Abstract Motivation Processing of transcripts at the 3′-end involves cleavage at a polyadenylation site followed by the addition of a poly(A)-tail. By selecting which site is cleaved, the process of alternative polyadenylation enables genes to produce transcript isoforms with different 3′-ends.
Leung, Michael K. K., Delong, Andrew, Frey, Brendan J.   +2 more
openaire   +5 more sources

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6-Methyladenosine Modification. [PDF]

Cancer Sci
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Wu Z, Xu R, Fang J, Liu B, Zhang C, Zhang S, Ni J.   +6 more
europepmc   +2 more sources

mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases

Genes and Diseases, 2023
The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase, poly(A)
Shuibin Lin, Siyao Guo
exaly   +3 more sources

Family C of Short Interspersed Elements in the Genomes of Lagomorphs: Structure, Evolution, Transcription and Transcript Polyadenylation [PDF]

Animals
Short Interspersed Elements (SINEs) are eukaryotic non-autonomous retrotransposons that rely on RNA polymerase III (pol III) for transcription. A subset of mammalian SINEs—designated T+ SINEs—harbors a canonical polyadenylation signal (AATAAA), a pol III
Ilia G. Ustyantsev, Sergei A. Kosushkin, Dmitri A. Kramerov, Danil V. Stasenko, Olga R. Borodulina   +4 more
doaj   +2 more sources

Specificity factors in cytoplasmic polyadenylation [PDF]

, 2013
Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development.
Hedda A. Meijer (7645400), A. Charlesworth (7645397), C. H. de Moor (7645403)   +2 more
core   +8 more sources

The CNOT4 Subunit of the CCR4‐NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis

Advanced Science, 2021
The CCR4‐NOT complex is a major mRNA deadenylase in eukaryotes, comprising the catalytic subunits CNOT6/6L and CNOT7/8, as well as CNOT4, a regulatory subunit with previously undetermined functions.
Xing‐Xing Dai, Yu Jiang, Jia‐Hui Gu, Zhi‐Yan Jiang, Yun‐Wen Wu, Chao Yu, Hao Yin, Jue Zhang, Qing‐Hua Shi, Li Shen, Qian‐Qian Sha, Heng‐Yu Fan   +11 more
doaj   +1 more source