RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]
, 2016 Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan +17 more
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Nuclear Polyadenylate-Binding Protein [PDF]
Molecular and Cellular Biology, 1985 Polyadenylate-binding activity can be detected in eluates from sodium dodecyl sulfate gels by a nitrocellulose filter-binding assay. Nuclear extracts from rat liver show a single peak of binding activity at 50 to 55 kilodaltons; cytoplasmic extracts show a single peak at 70 to 80 kilodaltons, corresponding to a 75-kilodalton protein previously ...
A B, Sachs, R D, Kornberg
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Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2014 The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld +6 more
doaj +1 more source
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
Cell Reports, 2021 Summary: Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals mineralize.
Olga Gewartowska +16 more
doaj +1 more source
Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]
, 2017 Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core +1 more source
Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation. [PDF]
PLoS Genetics, 2016 Polyadenylation has well characterised roles in RNA turnover and translation in a variety of biological systems. While polyadenylation on mitochondrial transcripts has been suggested to be a two-step process required to complete translational stop codons,
Ana Bratic +8 more
doaj +1 more source
Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]
, 2019 Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie +5 more
core +1 more source
A novel cause of DKC1‐related bone marrow failure: Partial deletion of the 3′ untranslated region
eJHaem, 2021 Telomere biology disorders (TBDs), including dyskeratosis congenita (DC), are a group of rare inherited diseases characterized by very short telomeres. Mutations in the components of the enzyme telomerase can lead to insufficient telomere maintenance in ...
Jonathan W. Arthur +14 more
doaj +1 more source
Non‐polyadenylated mRNAs from eukaryotes [PDF]
FEBS Letters, 1980 The investigation of eukaryotic mRNA has focussed on molecules that possess a 3’-terminal poly(A) seg ment [l-3] since they can be isolated easily by virtue of their high affinity for oligo(dT)-cellulose [4,5], poly(U)-Sepharose [6,7] or Millipore filters [8].
Katinakis, P.K. +2 more
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Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs [PDF]
, 2013 The reference annotations made for a genome sequence provide the framework for all subsequent analyses of the genome. Correct annotation is particularly important when interpreting the results of RNA-seq experiments where short sequence reads are mapped ...
A Derti +52 more
core +8 more sources