Results 31 to 40 of about 62,357 (236)

Overexpression of CPEB4 in glioma indicates a poor prognosis by promoting cell migration and invasion

Tumor Biology, 2017
Glioma is an aggressive malignancy with limited effective treatment and poor prognosis. Cytoplasmic polyadenylation element binding protein 4 is a regulator of gene transcription and has been reported to be associated with biological malignancy in ...
Liu Zhijun, Wu Dapeng, Jing Hong, Wang Guicong, Yuan Bingjian, Liu Honglin   +5 more
doaj   +1 more source

Detection of Differentially Expressed Cleavage Site Intervals Within 3′ Untranslated Regions Using CSI-UTR Reveals Regulated Interaction Motifs

Frontiers in Genetics, 2019
The length of untranslated regions at the 3′ end of transcripts (3′UTRs) is regulated by alternate polyadenylation (APA). 3′UTRs contain regions that harbor binding motifs for regulatory molecules. However, the mechanisms that coordinate the 3′UTR length
Benjamin J. Harrison, Benjamin J. Harrison, Benjamin J. Harrison, Juw Won Park, Juw Won Park, Cynthia Gomes, Jeffrey C. Petruska, Jeffrey C. Petruska, Jeffrey C. Petruska, Matthew R. Sapio, Michael J. Iadarola, Julia H. Chariker, Julia H. Chariker, Eric C. Rouchka, Eric C. Rouchka   +14 more
doaj   +1 more source

A new yeast poly(A) polymerase complex involved in RNA quality control [PDF]

, 2005
Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors.
Sabine Dettwiler (27038), Arno Friedlein (27039), Keller Walter, Stepánka Vanácová, Vanacova, S., Blank Diana, Martin Georges, Gérard Keith, Keller, W., Sabine Dettwiler, Jeannette Wolf (27035), Langen, H., Keith, G., Diana Blank (27037), Vanˇácˇová Sˇteˇpánka, Vanácová Stepánka, Georges Martin, Hanno Langen, Diana Blank, Hanno Langen (27040), Gérard Keith (27041), Keith Gérard, Walter Keller (27042), Wolf, J., Jeannette Wolf, Blank, D., Arno Friedlein, Wolf Jeannette, Štěpánka Vaňáčová (27034), Walter Keller, Friedlein, A., Langen Hanno, Friedlein Arno, Dettwiler, S., Dettwiler Sabine, Georges Martin (27036), Martin, G.   +36 more
core   +1 more source

Characterization of factors involved in the coupling of 3' end processing and splicing and in the 3' end formation of mRNA precursors [PDF]

, 2006
Eukaryotic mRNA precursors are processed at their 5’ and 3’ ends and are spliced prior to their export from the nucleus to the cytoplasm. Although all three processing reactions can be studied separately in vitro, they are coupled in vivo.
Kyburz Kooznetsoff, Andrea Martina
core   +1 more source

RNA binding protein Caprin-2 is a pivotal regulator of the central osmotic defense response

eLife, 2015
In response to an osmotic challenge, the synthesis of the antidiuretic hormone arginine vasopressin (AVP) increases in the hypothalamus, and this is accompanied by extension of the 3′ poly(A) tail of the AVP mRNA, and the up-regulation of the expression ...
Agnieszka Konopacka, Mingkwan Greenwood, Su-Yi Loh, Julian Paton, David Murphy   +4 more
doaj   +1 more source

Distinct roles of non-canonical poly(A) polymerases in RNA metabolism [PDF]

, 2009
Trf4p and Trf5p are non-canonical poly(A) polymerases and are part of the heteromeric protein complexes TRAMP4 and TRAMP5 that promote the degradation of aberrant and short-lived RNA substrates by interacting with the nuclear exosome. To assess the level
Schenk, L., Keller Walter, Vanacova, S., Blank Diana, Scherrer, T., San Paolo, Salvatore, Keller, W., André P Gerber, San Paolo, S., Gerber André P., Salvatore San Paolo, Tanja Scherrer, Diana Blank, Blank, Diana, Gerber, A. P., Blank, D., Scherrer Tanja, Gerber, André P., Schenk Luca, Walter Keller, Luca Schenk, Scherrer, Tanja, Vanacova Stepanka, Stepanka Vanacova, Vanacova, Stepanka, Paolo Salvatore San, Keller, Walter, Schenk, Luca   +27 more
core   +1 more source

Analysis of Polyadenylation Signal Usage with Full-Length Transcriptome in Spodoptera frugiperda (Lepidoptera: Noctuidae)

Insects, 2022
During the messenger RNA (mRNA) maturation process, RNA polyadenylation is a key step, and is coupled to the termination of transcription. Various cis-acting elements near the cleavage site and their binding factors would affect the process of ...
Liying Fang, Lina Guo, Min Zhang, Xianchun Li, Zhongyuan Deng   +4 more
doaj   +1 more source

Sequence Determinants for Nuclear Retention and Cytoplasmic Export of mRNAs and lncRNAs

Frontiers in Genetics, 2018
Eukaryotes are divided into two major compartments: the nucleus where RNA is synthesized and processed, and the cytoplasm, where mRNA is translated into proteins.
Alexander F. Palazzo, Eliza S. Lee
doaj   +1 more source

The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]

, 2007
Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
core   +1 more source

The transcriptional elongation rate regulates alternative polyadenylation in yeast

eLife, 2020
Yeast cells undergoing the diauxic response show a striking upstream shift in poly(A) site utilization, with increased use of ORF-proximal poly(A) sites resulting in shorter 3’ mRNA isoforms for most genes.
Joseph V Geisberg, Zarmik Moqtaderi, Kevin Struhl   +2 more
doaj   +1 more source