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Coupling of alternative splicing and alternative polyadenylation [PDF]
Acta Biochimica et Biophysica SinicaRNA splicing and 3′-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative ...
Zhang Xueying, Liu Feiyan, Zhou Yu
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Alternative Polyadenylation: Methods, Findings, and Impacts
Genomics, Proteomics & Bioinformatics, 2017 Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3â² ends originate from distinct polyadenylation sites of a single gene, is emerging as a mechanism widely used to regulate gene expression.
Wei Chen +5 more
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Alternative Polyadenylation in Human Diseases [PDF]
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang +2 more
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Transcriptional activity regulates alternative cleavage and polyadenylation
Molecular Systems Biology, 2011 Genes containing multiple pre‐mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs).
Zhe Ji +6 more
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mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases
Genes and Diseases, 2023 The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase, poly(A)
Siyao Guo, Shuibin Lin
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Alternative polyadenylation of mRNA precursors [PDF]
Nature Reviews Molecular Cell Biology, 2016 Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation.
Bin Tian +2 more
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Regulation and functions of alternative polyadenylation in fungi. [PDF]
MycologyAlternative polyadenylation (APA) has been implicated in regulating transcriptome diversity and gene expression by significantly altering mRNA abundance, stability, localisation, and translation. Understanding the comprehensive landscape of APA can provide valuable insights into the complexity of gene regulation.
Zhang L, Deng X, Ma W, Zhou T, Xu C.
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G-quadruplexes in the proximity 3′-UTR enhances alternative polyadenylation of Neogenin 1 [PDF]
iScienceSummary: Polyadenylation is a crucial step in mRNA maturation. Fifty percent of the time alternative polyadenylation sites (PASs) are used instead of canonical ones, affecting the length of the transcripts’ 3′-UTRs.
Pauline Lejault +3 more
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Stage-Specific Alternative Polyadenylation During Human Neural Differentiation Revealed by Integrated Long- and Short-Read Sequencing [PDF]
BiologyHuman embryonic stem cell (hESC) neural differentiation involves extensive APA; however, reliance on short-read sequencing in prior studies has offered only a limited view of its complexity and dynamic regulation. Here, we integrated Oxford Nanopore (ONT)
Zheqi Lou +7 more
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Alternative polyadenylation of mRNA and its role in cancer
Genes and Diseases, 2021 Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3' end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from the existence of multiple polyadenylation signals (PAS) within the same transcript, and results in the differential inclusion of sequence information at the 3' end.
Fuwen Yuan +2 more
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