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Alternative Polyadenylation in Human Diseases [PDF]
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang +2 more
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mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases
Genes and Diseases, 2023 The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase, poly(A)
Siyao Guo, Shuibin Lin
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The landscape of alternative polyadenylation in single cells of the developing mouse embryo
Nature Communications, 2021 Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are ...
Vikram Agarwal +3 more
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Frontiers in Cell and Developmental Biology, 2021 Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism required for cleavage and polyadenylation (CPA) of the 3′ untranslated region (3′ UTR) of mRNAs.
Shi-lu Chen +15 more
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Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR. [PDF]
PLoS ONE, 2015 About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that this coupling may be an intrinsic mechanism to directly regulate the host gene's expression ...
Ludwig Christian Hinske +7 more
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Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2014 The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld +6 more
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Molecules, 2021 The neuronal Hu/ELAV-like proteins HuB, HuC and HuD are a class of RNA-binding proteins that are crucial for proper development and maintenance of the nervous system. These proteins bind to AU-rich elements (AREs) in the untranslated regions (3′-UTRs) of
Rebecca M. Sena +5 more
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Scientific Reports, 2021 Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRNA isoforms in 70% of human genes.
Hyeon-Mu Cho +7 more
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Template-switching artifacts resemble alternative polyadenylation
BMC Genomics, 2019 Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally ...
Zsolt Balázs +5 more
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Alterations in polyadenylation and its implications for endocrine disease
Frontiers in Endocrinology, 2013 IntroductionPolyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation.
Anders eRehfeld +3 more
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