Results 1 to 10 of about 3,647,679 (259)

Coupling of alternative splicing and alternative polyadenylation [PDF]

Acta Biochimica et Biophysica Sinica
RNA splicing and 3′-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative ...
Zhang Xueying, Liu Feiyan, Zhou Yu
doaj   +5 more sources

The landscape of alternative polyadenylation in single cells of the developing mouse embryo

Nature Communications, 2021
Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are ...
Vikram Agarwal, Sereno Lopez-Darwin, David R. Kelley, Jay Shendure   +3 more
doaj   +2 more sources

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes. [PDF]

Nat Neurosci
In frontotemporal dementia and amyotrophic lateral sclerosis, the RNA-binding protein TDP-43 is depleted from the nucleus of neurons in the brain and spinal cord.
Zeng Y, Lovchykova A, Akiyama T, Rayner SL, Maheswari Jawahar V, Liu C, Sianto O, Guo C, Calliari A, Prudencio M, Dickson DW, Petrucelli L, Gitler AD.   +12 more
europepmc   +3 more sources

A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study

Nature Communications
Alternative polyadenylation plays an important role in cancer initiation and progression; however, current transcriptome-wide association studies mostly ignore alternative polyadenylation when identifying putative cancer susceptibility genes.
Hui Chen, Zeyang Wang, Lihai Gong, Qixuan Wang, Wenyan Chen, Jia Wang, Xuelian Ma, Ruofan Ding, Xing Li, Xudong Zou, Mireya Plass, Cheng Lian, Ting Ni, Gong-Hong Wei, Wei Li, Lin Deng, Lei Li   +16 more
doaj   +2 more sources

mRNA alternative polyadenylation (APA) in regulation of gene expression and diseases

Genes and Diseases, 2023
The mRNA polyadenylation plays essential function in regulation of mRNA metabolism. Mis-regulations of mRNA polyadenylation are frequently linked with aberrant gene expression and disease progression. Under the action of polyadenylate polymerase, poly(A)
Siyao Guo, Shuibin Lin
doaj   +2 more sources

Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2021
Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism required for cleavage and polyadenylation (CPA) of the 3′ untranslated region (3′ UTR) of mRNAs.
Shi-lu Chen, Shi-lu Chen, Zhong-xu Zhu, Xia Yang, Xia Yang, Li-li Liu, Li-li Liu, Yang-fan He, Yang-fan He, Ming-ming Yang, Ming-ming Yang, Xin-yuan Guan, Xin Wang, Xin Wang, Jing-ping Yun, Jing-ping Yun   +15 more
doaj   +2 more sources

NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance. [PDF]

Cell Discov
Alternative polyadenylation (APA) is critical for shaping transcriptome diversity and modulating cancer therapeutic resistance. While lactate is a well-established metabolic signal in cancer progression, its role in APA regulation remains unclear.
Lin J, Yin Y, Cao J, Zhang Y, Chen J, Chen R, Zou B, Huang C, Lv Y, Xu S, Yang H, Lin P, Xie D.   +12 more
europepmc   +2 more sources

Stage-Specific Alternative Polyadenylation During Human Neural Differentiation Revealed by Integrated Long- and Short-Read Sequencing [PDF]

Biology
Human embryonic stem cell (hESC) neural differentiation involves extensive APA; however, reliance on short-read sequencing in prior studies has offered only a limited view of its complexity and dynamic regulation. Here, we integrated Oxford Nanopore (ONT)
Zheqi Lou, Xianyan Zeng, Tinghui Jiang, Peizhen Du, Jiyao Rao, Xinyan Dai, Haishuang Lin, Yong Zhu   +7 more
doaj   +2 more sources

G-quadruplexes in the proximity 3′-UTR enhances alternative polyadenylation of Neogenin 1 [PDF]

iScience
Summary: Polyadenylation is a crucial step in mRNA maturation. Fifty percent of the time alternative polyadenylation sites (PASs) are used instead of canonical ones, affecting the length of the transcripts’ 3′-UTRs.
Pauline Lejault, François Bolduc, Marc-Antoine Turcotte, Jean Pierre Perreault   +3 more
doaj   +2 more sources

HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution [PDF]

mBio
HIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures.
Charlotte Luchsinger, Annie Zhi Dai, Hari Yalamanchili, Aiswarya Balakrishnan, Kai-Lieh Huang, Cinzia Bertelli, Bin Cui, Ramon Lorenzo-Redondo, Eric J. Wagner, Felipe Diaz-Griffero   +9 more
doaj   +2 more sources