Results 41 to 50 of about 30,645 (223)
Regulation of alternative splicing and polyadenylation in neurons
Life Science Alliance, 2023 Cell-type–specific gene expression is a fundamental feature of multicellular organisms and is achieved by combinations of regulatory strategies. Although cell-restricted transcription is perhaps the most widely studied mechanism, co-transcriptional and post-transcriptional processes are also central to the spatiotemporal control of gene functions.
Seungjae Lee, Joseph I Aubee, Eric C Lai
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Alternative polyadenylation [PDF]
Plant Signaling & Behavior, 2009 Based on comparative genome analyses, the increases in protein-coding gene number could not account for the increases of morphological and behavioral complexity of higher eukaryotes. Transcriptional regulations, alternative splicing and the involvement of non-coding RNA in gene expression regulations have been credited for the drastic increase of ...
Denghui, Xing, Qingshun Quinn, Li
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CRISPRpas: programmable regulation of alternative polyadenylation by dCas9 [PDF]
Nucleic Acids Research, 2021 Abstract Most human protein-coding genes produce alternative polyadenylation (APA) isoforms that differ in 3′ UTR size or, when coupled with splicing, have variable coding sequences. APA is an important layer of gene expression program critical for defining cell identity.
Jihae Shin +6 more
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Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
Genome Biology, 2021 Background Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends.
Ankeeta Shah +3 more
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Characterization of factors involved in the coupling of 3' end processing and splicing and in the 3' end formation of mRNA precursors [PDF]
, 2006 Eukaryotic mRNA precursors are processed at their 5’ and 3’ ends and are spliced prior to their export from the nucleus to the cytoplasm. Although all three processing reactions can be studied separately in vitro, they are coupled in vivo.
Kyburz Kooznetsoff, Andrea Martina
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Driving glioblastoma growth by alternative polyadenylation [PDF]
Cell Research, 2014 Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.
Ting, Han, John K, Kim
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Alternative polyadenylation and RNA-binding proteins [PDF]
Journal of Molecular Endocrinology, 2016 Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and ...
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The contribution of alternative polyadenylation to the cancer phenotype [PDF]
Carcinogenesis, 2017 Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as alternative polyadenylation (APA ...
Chioniso P Masamha, Eric J Wagner
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RNA-seq Quantification of Alternative Polyadenylation (QAPA)
, 2018 <p>RNA-seq Quantification of Alternative Polyadenylation (QAPA)</p> <p>Analysis of alternative polyadenylation (APA) from RNA-seq data (human and mouse). QAPA consists of two main components:</p> <ol> <li>Extraction
Quaid Morris +5 more
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Insects, 2022 During the messenger RNA (mRNA) maturation process, RNA polyadenylation is a key step, and is coupled to the termination of transcription. Various cis-acting elements near the cleavage site and their binding factors would affect the process of ...
Liying Fang +4 more
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