Results 41 to 50 of about 3,647,679 (259)

Comprehensive profiling of rhizome-associated alternative splicing and alternative polyadenylation in moso bamboo (Phyllostachys edulis). [PDF]

, 2017
Moso bamboo (Phyllostachys edulis) represents one of the fastest-spreading plants in the world, due in part to its well-developed rhizome system. However, the post-transcriptional mechanism for the development of the rhizome system in bamboo has not been
Cai, Dawei, Gao, Yubang, Gu, Lianfeng, Lin, Chentao, Ma, Liuyin, Wang, Huiyuan, Wang, Taotao, Wang, Yongsheng, Zhang, Hangxiao   +8 more
core   +1 more source

Extensive alternative polyadenylation during zebrafish development [PDF]

Genome Research, 2012
The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3′ untranslated regions (3′ UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-seq) to map poly(A) sites at eight developmental stages and tissues in the zebrafish.
Ulitsky, Igor, Shkumatava, Alena, Jan, Calvin H., Subtelny, Alexander Orest, Koppstein, David Neal Pira, Bell, George W., Sive, Hazel L., Bartel, David   +7 more
openaire   +4 more sources

Sense-oriented AluYRa1 elements provide a lineage-specific transcription environment for polyadenylation

Scientific Reports, 2021
Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRNA isoforms in 70% of human genes.
Hyeon-Mu Cho, Se-Hee Choe, Young-Hyun Kim, Hye-Ri Park, Hee-Eun Lee, Ja-Rang Lee, Sang-Je Park, Jae-Won Huh   +7 more
doaj   +1 more source

Alternative polyadenylation: methods, mechanism, function, and role in cancer

Journal of experimental & clinical cancer research : CR, 2021
Occurring in over 60% of human genes, alternative polyadenylation (APA) results in numerous transcripts with differing 3’ends, thus greatly expanding the diversity of mRNAs and of proteins derived from a single gene.
Yi Zhang, Lian Liu, Qiongzi Qiu, Qing Zhou, Jinwang Ding, Yan Lu, Pengyuan Liu   +6 more
semanticscholar   +1 more source

CPSF30-L-mediated recognition of mRNA m6A modification controls alternative polyadenylation of nitrate signaling-related gene transcripts in Arabidopsis.

Molecular Plant, 2021
N6-methyladenosine (m6A), a ubiquitous internal modification of eukaryotic mRNAs, plays a vital role in almost every aspect of mRNA metabolism. However, evidence regarding the role of m6A in regulating alternative polyadenylation (APA) is limited. APA is
Yifeng Hou, Jing Sun, Baixing Wu, Yangyang Gao, H. Nie, Zhentian Nie, Shuxuan Quan, Yong Wang, Xiaofeng Cao, Sisi Li   +9 more
semanticscholar   +1 more source

Biased alternative polyadenylation in human tissues [PDF]

Genome Biology, 2005
Abstract Background Alternative polyadenylation is one of the mechanisms in human cells that give rise to a variety of transcripts from a single gene. More than half of the human genes have multiple polyadenylation sites (poly(A) sites), leading to variable mRNA and protein products.
Zhang, Haibo, Lee, Ju Youn, Tian, Bin
openaire   +2 more sources

Mechanisms and Consequences of Alternative Polyadenylation [PDF]

Molecular Cell, 2011
Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode multiple mRNA transcripts. In some cases, this changes the mRNA coding potential; in other cases, the code remains unchanged but the 3' UTR length is ...
Di Giammartino, Dafne Campigli, Nishida, Kensei, Manley, James L.   +2 more
openaire   +2 more sources

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]

, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Barton, Geoffrey J., Gould, Peter D., Hall, Anthony J. W., Knop, Katarzyna, Mackinnon, Katarzyna, Parker, Matthew T., Schurch, Nicholas J., Sherwood, Anna V., Simpson, Gordon G.   +8 more
core   +3 more sources

Alterations in polyadenylation and its implications for endocrine disease

Frontiers in Endocrinology, 2013
IntroductionPolyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation.
Anders eRehfeld, Mireya ePlass, Anders eKrogh, Lennart eFriis-Hansen   +3 more
doaj   +1 more source

CFIm25 in Solid Tumors: Current Research Progress

Technology in Cancer Research & Treatment, 2020
Cleavage factor I m25 is a newly discovered solid tumor-related gene, however, its precise role in cancer pathogenesis has not yet been characterized.
Xiaojie Sun MD, PhD, Ji Li MD, PhD, Xun Sun MMed, Wanqi Liu MD, PhD, Xiangwei Meng MD, PhD   +4 more
doaj   +1 more source