Results 51 to 60 of about 30,645 (223)
Alternative Polyadenylation Drives Runaway Pro-Inflammatory Macrophages in Periodontitis by Enabling Escape From miRNA Repression. [PDF]
Cell ProlifAPA‐Guided Therapeutic miRNA Selection for Periodontitis. ABSTRACT Periodontitis is a chronic inflammatory disease driven by a dysregulated host immune response, in which macrophage‐mediated inflammation shifts from protective to pathological. While monocyte‐derived macrophages (MDMs) are known to adopt a destructive, M1‐like pro‐inflammatory phenotype,
Zhang J +6 more
europepmc +2 more sources
Alternative polyadenylation events in the U1-gene deletion strains.
, 2023 Alternative polyadenylation events in the U1-gene deletion strains.
Zhen-Zhen Zhou (486232) +5 more
core +1 more source
RNA regulatory elements and polyadenylation in plants
Frontiers in Plant Science, 2012 Alternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant.
Arthur G. Hunt
doaj +1 more source
BMC Medical Genomics, 2019 Background Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a ...
Radhika Patel +4 more
doaj +1 more source
Frontiers in Genetics, 2022 Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that most transcripts in humans undergo alternative splicing and alternative polyadenylation.
Ryan Lusk +8 more
doaj +1 more source
Conservation of alternative polyadenylation patterns in mammalian genes [PDF]
BMC Genomics, 2006 Abstract Background Alternative polyadenylation is a widespread mechanism contributing to transcript diversity in eukaryotes. Over half of mammalian genes are alternatively polyadenylated. Our understanding of poly(A) site evolution is limited by the lack of a reliable identification of conserved, equivalent poly(A ...
Ara, Takeshi +4 more
openaire +3 more sources
Regulation and function of alternative polyadenylation in development and differentiation
RNA Biology, 2023 Alternative processing of nascent mRNAs is widespread in eukaryotic organisms and greatly impacts the output of gene expression. Specifically, alternative cleavage and polyadenylation (APA) is a co-transcriptional molecular process that switches the polyadenylation site (PAS) at which a nascent mRNA is cleaved, resulting in mRNA isoforms with different
Lorenzo Gallicchio +3 more
openaire +3 more sources
Reprogramming of 3' untranslated regions of mRNAs by alternative polyadenylation in generation of pluripotent stem cells from different cell types. [PDF]
PLoS ONE, 2009 The 3' untranslated regions (3'UTRs) of mRNAs contain cis elements involved in post-transcriptional regulation of gene expression. Over half of all mammalian genes contain multiple polyadenylation sites that lead to different 3'UTRs for a gene.
Zhe Ji, Bin Tian
doaj +1 more source
Relationship between NUDT21 mediated alternative polyadenylation process and tumor
Frontiers in Oncology, 2023 Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3’ end of RNA polymerase II transcripts from over 60% of human genes.
Shan Xiao +8 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source