Results 51 to 60 of about 3,647,679 (259)
International Journal of Molecular Sciences, 2023 Precursor message RNA requires processing to generate mature RNA. Cleavage and polyadenylation at the 3′-end in the maturation of mRNA is one of key processing steps in eukaryotes.
Jing Wu, Ligeng Ma, Ying Cao
semanticscholar +1 more source
BMC Bioinformatics, 2006 Background The three major mechanisms that regulate transcript formation involve the selection of alternative sites for transcription start (TS), splicing, and polyadenylation.
Lopez Fabrice +6 more
doaj +1 more source
A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]
, 2017 mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun +14 more
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Driving glioblastoma growth by alternative polyadenylation [PDF]
Cell Research, 2014 Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.
Ting, Han, John K, Kim
openaire +2 more sources
Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1.
Molecules and Cells, 2022 Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the diversity of mRNA transcripts. 3' UTR shortening through APA correlates with enhanced cellular proliferation and is a widespread phenomenon in tumor cells.
Jingwen Song +15 more
semanticscholar +1 more source
RNA-binding protein CPEB1 remodels host and viral RNA landscapes. [PDF]
, 2016 Host and virus interactions occurring at the post-transcriptional level are critical for infection but remain poorly understood. Here, we performed comprehensive transcriptome-wide analyses revealing that human cytomegalovirus (HCMV) infection results in
Aigner, Stefan +17 more
core +2 more sources
Scientific Reports, 2017 Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li +3 more
doaj +1 more source
Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
Genome Biology, 2021 Background Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends.
Ankeeta Shah +3 more
doaj +1 more source
The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization
Frontiers in Genetics, 2022 Alternative polyadenylation (APA) is a widespread and conserved regulatory mechanism that generates diverse 3′ ends on mRNA. APA patterns are often tissue specific and play an important role in cellular processes such as cell proliferation ...
Ankita Arora +5 more
semanticscholar +1 more source
Virulence- and signaling-associated genes display a preference for long 3′UTRs during rice infection and metabolic stress in the rice blast fungus [PDF]
, 2019 Generation of mRNA isoforms by alternative polyadenylation (APA) and their involvement in regulation of fungal cellular processes, including virulence, remains elusive.
Demuez, Marie +5 more
core +1 more source