Results 71 to 80 of about 3,647,679 (259)

E2F mediates enhanced alternative polyadenylation in proliferation [PDF]

Genome Biology, 2012
Abstract Background The majority of mammalian genes contain multiple poly(A) sites in their 3' UTRs. Alternative cleavage and polyadenylation are emerging as an important layer of gene regulation as they generate transcript isoforms that differ in their 3' UTRs, thereby modulating genes' response to 3 ...
Elkon R, Drost J, van Haaften G, Jenal M, Schrier M, Vrielink JA, Agami R.   +6 more
openaire   +2 more sources

Analysis of Polyadenylation Signal Usage with Full-Length Transcriptome in Spodoptera frugiperda (Lepidoptera: Noctuidae)

Insects, 2022
During the messenger RNA (mRNA) maturation process, RNA polyadenylation is a key step, and is coupled to the termination of transcription. Various cis-acting elements near the cleavage site and their binding factors would affect the process of ...
Liying Fang, Lina Guo, Min Zhang, Xianchun Li, Zhongyuan Deng   +4 more
doaj   +1 more source

A new yeast poly(A) polymerase complex involved in RNA quality control [PDF]

, 2005
Eukaryotic cells contain several unconventional poly(A) polymerases in addition to the canonical enzymes responsible for the synthesis of poly(A) tails of nuclear messenger RNA precursors.
Štěpánka Vaňáčová, Jeannette Wolf, Georges Martin, Diana Blank, Sabine Dettwiler, Arno Friedlein, Hanno Langen, Gérard Keith, Walter Keller, Phillip Zamore, Wahle, Minvielle-Sebastia, Zhao, Edmonds, Proudfoot, Zorio, Aravind, Holm, Martin, Preker, Martin, Martin, Bard, Read, Saitoh, Wang, Sadoff, Wang, Wang, Crittenden, Kwak, Keller, van Hoof, Kuai, Kadaba, Mitchell, O'Hara, Li, Cheng, Dreyfus, Inoue, Martin, Puig, Lingner, de la Cruz, Wang, Vijayraghavan, Anderson, Gerber, Dirheimer, Mitchell, Walowsky, Dannull, Amarasinghe, Castaño, Basavappa, Kushner, Symmons, Parker, Torchet, Fromont-Racine, Ohnacker, Dichtl, Fountoulakis, Wilm, Dirheimer, Keith, Senger, Dichtl, Christofori, Falquet, Rain   +71 more
core   +4 more sources

CRISPRpas: programmable regulation of alternative polyadenylation by dCas9 [PDF]

Nucleic Acids Research, 2021
Abstract Most human protein-coding genes produce alternative polyadenylation (APA) isoforms that differ in 3′ UTR size or, when coupled with splicing, have variable coding sequences. APA is an important layer of gene expression program critical for defining cell identity.
Jihae Shin, Qingbao Ding, Luyang Wang, Yange Cui, Erdene Baljinnyam, Aysegul Guvenek, Bin Tian   +6 more
openaire   +2 more sources

Intragenic heterochromatin‐mediated alternative polyadenylation modulates miRNA and pollen development in rice

New Phytologist, 2021
Summary Despite a much higher proportion of intragenic heterochromatin‐containing genes in crop genomes, the importance of intragenic heterochromatin in crop development remains unclear.

semanticscholar   +1 more source

The regulation of Hox gene expression during animal development [PDF]

, 2013
Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns ...
Alonso, Claudio R, Mallo, Moisés
core   +1 more source

TAPAS: tool for alternative polyadenylation site analysis [PDF]

Bioinformatics, 2018
AbstractMotivationThe length of the 3′ untranslated region (3′ UTR) of an mRNA is essential for many biological activities such as mRNA stability, sub-cellular localization, protein translation, protein binding and translation efficiency. Moreover, correlation between diseases and the shortening (or lengthening) of 3′ UTRs has been reported in the ...
Ashraful Arefeen, Juntao Liu, Xinshu Xiao, Tao Jiang   +3 more
openaire   +4 more sources

Alternative polyadenylation couples to transcription initiation: Insights from ELAV-mediated 3' UTR extension

, 2015
Transcription initiation and mRNA maturation were long considered co-occurring but separately regulated events of gene control. In the past decade, gene promoters, the platforms of transcription initiation, have been assigned additional functions such as
Hilgers, V.
core   +1 more source

The Transcriptional Landscape of Marek’s Disease Virus in Primary Chicken B Cells Reveals Novel Splice Variants and Genes [PDF]

, 2019
Marek’s disease virus (MDV) is an oncogenic alphaherpesvirus that infects chickens and poses a serious threat to poultry health. In infected animals, MDV efficiently replicates in B cells in various lymphoid organs.
Bertzbach, Luca D., Härtle, Sonja, Höper, Dirk, Karger, Axel, Kaufer, Benedikt B., Kheimar, Ahmed M., Pauker, Viktoria I., Pfaff, Florian   +7 more
core   +2 more sources

RNA regulatory elements and polyadenylation in plants

Frontiers in Plant Science, 2012
Alternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant.
Arthur G. Hunt
doaj   +1 more source