Results 91 to 100 of about 30,645 (223)

NFYA alternative cleavage and polyadenylation in cancer

, 2022
The majority of human genes can undergo alternative cleavage and polyadenylation resulting in the expression of distinct transcript isoforms and in a different microRNA-mediated regulation under certain conditions and states.
C. Ferrari, C. Pandini, M. Chiara, G. Pagani, P. Gandellini   +4 more
core  

Inference of Computational Models of Alternative Polyadenylation and Splicing

, 2018
Instructions from the genome are first copied to make messenger RNAs, which are then translated to make proteins. To expand the repertoire of these instructions, cells can modify the messenger RNAs in different ways.
Leung, Michael Ka Kit
core   +1 more source

Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms

Viruses
Parvoviruses have compact genomic organizations with overlapping open reading frames and thus utilize alternative RNA processing strategies, alternative splicing, alternative polyadenylation, and alternative translation mechanisms to generate a range of ...
Lisa K. Uhl, Olufemi O. Fasina
doaj   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Role of Arginine Methylation in Alternative Polyadenylation of VEGFR-1 (Flt-1) pre-mRNA

, 2020
Mature mRNA is generated by the 3ʹ end cleavage and polyadenylation of its precursor pre-mRNA. Eukaryotic genes frequently have multiple polyadenylation sites, resulting in mRNA isoforms with different 3ʹ-UTR lengths that often encode different C ...
Hidehito Saito-Takatsuji, Takayuki Ikeda, Hideto Yonekura, Yasuo Yoshitomi   +3 more
core   +1 more source

Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site

BMC Genomics, 2009
Background Alternative polyadenylation sites within a gene can lead to alternative transcript variants. Although bioinformatic analysis has been conducted to detect polyadenylation sites using nucleic acid sequences (EST/mRNA) in the public databases ...
Yu Peng, Wang Pingzhang, Gao Peng, Shi Taiping, Ma Dalong   +4 more
doaj   +1 more source

Prospects of multipurpose biomonitoring for fisheries assessment based on environmental nucleic acids

Journal of Fish Biology, EarlyView.
Abstract Methods using environmental nucleic acids have become highly effective for monitoring aquatic biodiversity, with an array of suitable use cases, including metrics for fisheries assessment. Traditional methods for assessing fish populations often rely on invasive techniques with limited spatial and temporal coverage.
Ana Ramón‐Laca, Krista M. Nichols, Kim M. Parsons, Ramón Gallego, David R. Vieites, Ignacio Doadrio, Ana Riesgo   +6 more
wiley   +1 more source

Resolving CNS mRNA Heterogeneity: Examining mRNA Alternative Polyadenylation at a Cell-Type-Specific Level

, 2017
Alternative polyadenylation often regulates mRNA isoform usage. In this issue of Neuron, Hwang et al. (2017) describe a powerful new cell-type-specific methodology, cTag-PAPERCLIP, which can be used to study alternative polyadenylation in the CNS ...
Myriam Heiman, Therrien, Martine, Heiman, Myriam, Martine Therrien   +3 more
core   +1 more source

Coupling of both a transactivation module and a double‐stranded DNA‐binding domain boosts Cas12i3 variant‐based cytosine and adenine editing in plants

Journal of Integrative Plant Biology, EarlyView.
Fusions of a transactivation module and a double‐stranded DNA‐binding domain produced effective Cas12i3 variant‐based cytosine and adenine base editors, with improved C‐to‐T and A‐to‐G base editing efficiency and expanded editing window. Generated herbicide‐resistant rice germplasm by using these base editors demonstrates their potential for precise ...
Chen Zhang, Jingying Li, Yucai Li, Lei Yan, Christina Seok Yien Yong, Shaoya Li, Yubing He, Lanqin Xia   +7 more
wiley   +1 more source

Alternative Polyadenylation in Sarcocystis neurona

, 2018
This project studied the occurrence of alternative polyadenylation during the growth of Sarcocystis neurona. S. neurona is an obligate intracellular parasite that causes equine protozoal myeloencephalitis.
Stevens, Ashley
core