Results 81 to 90 of about 3,647,679 (259)

Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel

Frontiers in Genetics, 2022
Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that most transcripts in humans undergo alternative splicing and alternative polyadenylation.
Ryan Lusk, Paula L. Hoffman, Spencer Mahaffey, Samuel Rosean, Harry Smith, Jan Silhavy, Michal Pravenec, Boris Tabakoff, Laura M. Saba   +8 more
doaj   +1 more source

VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation

Cell Discovery, 2018
N6-methyladenosine (m6A) is enriched in 3′untranslated region (3′UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch.
Y. Yue, Jun Liu, X. Cui, Jie Cao, Guanzheng Luo, Zezhou Zhang, T. Cheng, Minsong Gao, Xiao Shu, Honghui Ma, Fengqin Wang, Xinxia Wang, Bin Shen, Yizhen Wang, Xinhua Feng, Chuan He, Jianzhao Liu   +16 more
semanticscholar   +1 more source

The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function

Immunological Reviews, 2021
The latest advances in next‐generation sequencing studies and transcriptomic profiling over the past decade have highlighted a surprising frequency of genes regulated by RNA processing mechanisms in the immune system.
D. Blake, K. Lynch
semanticscholar   +1 more source

Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

BMC Medical Genomics, 2019
Background Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a ...
Radhika Patel, Cillian Brophy, Mark Hickling, Jonathan Neve, André Furger   +4 more
doaj   +1 more source

MAAPER: model-based analysis of alternative polyadenylation using 3′ end-linked reads

Genome Biology, 2021
Most eukaryotic genes express alternative polyadenylation (APA) isoforms. A growing number of RNA sequencing methods, especially those used for single-cell transcriptome analysis, generate reads close to the polyadenylation site (PAS), termed nearSite ...
W. Li, Dinghai Zheng, Ruijia Wang, Bin Tian   +3 more
semanticscholar   +1 more source

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing [PDF]

, 2018
Kinetoplastid parasites—trypanosomes and leishmanias—infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Barrett, Michael P., Begolo, Daniela, Bengaly, Zakaria, Clayton, Christine, Freund, Yvonne, Gillingwater, Kirsten, Giordani, Federica, Pöhner, Ina, Rowan, Timothy G., Vincent, Isabel M., Wade, Rebecca C., Witty, Michael J.   +11 more
core   +3 more sources

RBBP6 maintains glioblastoma stem cells through CPSF3-dependent alternative polyadenylation

Cell Discovery
Glioblastoma is one of the most lethal malignant cancers, displaying striking intratumor heterogeneity, with glioblastoma stem cells (GSCs) contributing to tumorigenesis and therapeutic resistance.
Peng Lin, Wenyan Chen, Zhilin Long, Jichuan Yu, Jiayao Yang, Z. Xia, Qiulian Wu, Xinyu Min, Jing Tang, Ya Cui, Fuyi Liu, Chun Wang, Jian Zheng, Wei Li, Jeremy N. Rich, Lei Li, Qi Xie   +16 more
semanticscholar   +1 more source

The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation

eLife, 2021
Gene regulation via N6-methyladenosine (m6A) in mRNA involves RNA-binding proteins that recognize m6A via a YT521-B homology (YTH) domain. The plant YTH domain proteins ECT2 and ECT3 act genetically redundantly in stimulating cell proliferation during ...
Laura Arribas‐Hernández, Sarah Rennie, Michael A. Schon, Carlotta Porcelli, Balaji Enugutti, R. Andersson, Michael D. Nodine, P. Brodersen   +7 more
semanticscholar   +1 more source

Components required for in vitro cleavage and polyadenylation of eukaryotic mRNA [PDF]

, 1988
We have studied in vitro cleavage/polyadenylation of precursor RNA containing herpes simplex virus type 2 poly A site sequences and have analysed four RNA/protein complexes which form during in vitro reactions.
Clements, J.B., McLauchlan, J., Moore, C.L., Simpson, S.   +3 more
core   +1 more source

Alternative Cleavage and Polyadenylation during Colorectal Cancer Development [PDF]

Clinical Cancer Research, 2012
Abstract Purpose: Alternative cleavage and polyadenylation (APA) of mRNAs is a phenomenon that alters 3′-untranslated region length leading to altered posttranscriptional regulation of gene expression. Changing APA patterns have been shown to result in misregulation of genes involved in carcinogenesis; therefore, we hypothesized that ...
Morris AR, Bos A, Diosdado B, Rooijers K, Elkon R, Bolijn AS, Carvalho B, Meijer GA, Agami R.   +8 more
openaire   +4 more sources