Results 61 to 70 of about 3,647,679 (259)

Alternative polyadenylation and RNA-binding proteins [PDF]

Journal of Molecular Endocrinology, 2016
Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis-elements which harbor not only microRNA but also RNA-binding protein (RBP) binding sites that have significant effect on the stability and ...
openaire   +3 more sources

Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs [PDF]

, 2013
The reference annotations made for a genome sequence provide the framework for all subsequent analyses of the genome. Correct annotation is particularly important when interpreting the results of RNA-seq experiments where short sequence reads are mapped ...
A Derti, A Dobin, A Sherstnev, AI Reid, Alexander Sherstnev, B Langmead, BJ Haas, BJ Haas, BS Yoon, C Burge, C Cole, C Luo, C Trapnell, CE Joyce, CH Jan, Christian Cole, Céline Duc, D Brawand, DM Church, F Ozsolak, F Ozsolak, F Ozsolak, Geoffrey J. Barton, Gordon G. Simpson, H Stroud, H Zou, HK Saini, I Ulitsky, J Bracht, J Harrow, JE Collins, JH Yang, Junfang Song, Kate G. Storey, L Jiang, M Fujii, M Garber, M Yandell, MB Gerstein, Nicholas J. Schurch, P Lamesch, PE Boardman, Sara J. Brown, T Pelissier, Thomas Preiss, TS Becker, V Curwen, V Hamburger, W. H. Irwin McLean, X Cai, Y Kurihara, Y Lee, Z Moqtaderi   +52 more
core   +8 more sources

Analysis of alternative polyadenylation from single-cell RNA-seq using scDaPars reveals cell subpopulations invisible to gene expression

Genome Research, 2021
Alternative polyadenylation (APA) is a major mechanism of post-transcriptional regulation in various cellular processes including cell proliferation and differentiation, but the APA heterogeneity among single cells remains largely unknown.
Yipeng Gao, Lei Li, C. Amos, Wei Li
semanticscholar   +1 more source

Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]

, 2017
Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core   +1 more source

Upregulation of Functional Kv11.1 Isoform Expression by Inhibition of Intronic Polyadenylation with Antisense Morpholino Oligonucleotides

, 2014
The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing; intron 9 splicing leads to the formation of a functional, full-length Kv11 ...
Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng   +2 more
core   +2 more sources

CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression

Journal of experimental & clinical cancer research : CR, 2021
Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3′ termini. Increasing evidence has revealed that APA is actively involved in development and disease, including ...
Sheng Tan, Ming Zhang, Xinglong Shi, Keshuo Ding, Qiang Zhao, Qianying Guo, Hao Wang, Zhengsheng Wu, Yani Kang, T. Zhu, Jielin Sun, Xiaodong Zhao   +11 more
semanticscholar   +1 more source

Nuclear m6A reader YTHDC1 suppresses proximal alternative polyadenylation sites by interfering with the 3′ processing machinery

EMBO Reports, 2022
N6‐methyladenosine (m6A) and alternative polyadenylation (APA) are important regulators of gene expression in eukaryotes. Recently, it was found that m6A is closely related to APA.
Liutao Chen, Yonggui Fu, Zhijie Hu, Ke Deng, Zili Song, Susu Liu, Mengxia Li, Xin Ou, Runze Wu, Mian Liu, Rui Li, Shuiying Gao, Lin Cheng, Shangwu Chen, A. Xu   +14 more
semanticscholar   +1 more source

Regulation of alternative polyadenylation by genomic imprinting [PDF]

Genes & Development, 2008
Maternally and paternally derived alleles can utilize different promoters, but allele-specific differences in cotranscriptional processes have not been reported. We show that alternative polyadenylation sites at a novel murine imprinted gene ( H13 ) are utilized in an allele-specific manner ...
Wood, Andrew J., Schulz, Reiner, Woodfine, Kathryn, Koltowska, Katarzyna, Beechey, Colin V., Peters, Jo, Bourc'his, Deborah, Oakey, Rebecca J.   +7 more
openaire   +4 more sources

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

Nature Communications, 2022
Most genes in higher eukaryotes express isoforms with distinct 3’ untranslated regions (3’ UTRs), generated by alternative polyadenylation (APA). Since 3’ UTRs are predominant locations of post-transcriptional regulation, APA can render such programs ...
Seungjae Lee, Yen-Chung Chen, Fca Consortium, A. Gillen, J. Taliaferro, B. Deplancke, Hongjie Li, E. Lai   +7 more
semanticscholar   +1 more source

Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells [PDF]

, 2017
Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. The standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for PDAC management due to the rapid acquisition of drug resistance by patients.
Bielli, Pamela, Capurso, Gabriele, Delle Fave, Gianfranco, Farini, Donatella, Panzeri, Valentina, Passacantilli, Ilaria, Pilozzi, Emanuela, Sette, Claudio   +7 more
core   +2 more sources