Results 101 to 110 of about 30,645 (223)

Molecular mechanisms for CFIm-mediated regulation of mRNA alternative polyadenylation

, 2017
Raw experimental data used for the manuscript titled "Molecular mechanisms for CFIm-mediated regulation of mRNA alternative ...
Shi, Y (via Mendeley Data)
core   +1 more source

Plant polyadenylation factors: conservation and variety in the polyadenylation complex in plants

BMC Genomics, 2012
Background Polyadenylation, an essential step in eukaryotic gene expression, requires both cis-elements and a plethora of trans-acting polyadenylation factors. The polyadenylation factors are largely conserved across mammals and fungi.
Hunt Arthur G, Xing Denghui, Li Qingshun Q   +2 more
doaj   +1 more source

The GSK3/SHAGGY‐like OsGSK3 phosphorylates and inhibits phase separation of OsFCA at Ser‐43 and Ser‐45 to regulate brassinosteroid signaling and rice architecture

New Phytologist, EarlyView.
A working model for GLYCOGEN SYNTHASE KINASE 3‐mediated phosphorylation of FLOWERING CONTROL LOCUS A in the regulation of brassinosteroid signaling and rice growth and development. Summary Brassinosteroid (BR) signaling plays a critical role in rice (Oryza sativa L.) grain development.
Jiaqi Zhang, Fan Wang, Sijia Zhang, Qian Yu, Qimiao Dong, Jianbo Li, Xianglei Wei, Huaying Du, Ye Shen, Rong Mu, Yanxiao Jia, Jinping Cheng, Hongsheng Zhang, Ji Huang, Xiuying Gao   +14 more
wiley   +1 more source

The Role of HuD in Alternative Splicing and Alternative Polyadenylation in the Brain

, 2020
RNA binding proteins (RBPs) regulate several processes in the cell, including alternative splicing and alternative polyadenylation. Hu proteins, a class of ELAV-like RBPs, are crucial for proper development and maintenance of the nervous system.
Sena, Rebecca M
core  

Model of miRNA regulation by alternative polyadenylation sites located within introns.

, 2015
Alternative polyadenylation causes a change in possible miRNA binding sites and truncation of mRNA. Polyadenylation that results in a shortening 3'-UTR generally lowers regulation by miRNA, while a lengthening 3'-UTR increases regulation by miRNA ...
William G. Loudon (703149), Xi Zhang (83736), Mustafa H. Kabeer (703148), Jiang F. Zhong (185216), Shengwen Calvin Li (703150), Long T. Vu (703146), Vic Keschrumrus (703147), Qingning Su (363844)   +7 more
core   +1 more source

Long‐Term Salt Exposure Reprograms the Nicotiana tabacum BY‐2 Suspension Proteome and Metabolome Toward Stabilization of the Core Metabolic Pathways, Protein Turnover Machinery Modifications, and Protective Metabolome Adjustments

Plant, Cell &Environment, EarlyView.
ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz, Łukasz Marczak, Aleksander Strugała, Maria Tomys, Ewelina Ratajczak, Tomasz Skrzypczak, Przemysław Wojtaszek, Anna Kasprowicz‐Maluśki, Agnieszka Szuba   +8 more
wiley   +1 more source

The role of alternative polyadenylation in breast cancer

Frontiers in Genetics
Breast cancer (BC), as a highly prevalent malignant tumor worldwide, is still unclear in its pathogenesis and has poor therapeutic outcomes. Alternative polyadenylation (APA) is a post-transcriptional regulatory mechanism widely found in eukaryotes. Precursor mRNA (pre-mRNA) undergoes the APA process to generate multiple mRNA isoforms with different ...
Ping Qiao, Caihong Zhang, Yingxu Shi, Hua Du, Hua Du   +4 more
openaire   +3 more sources

Molecular Interplay of PARN and Telomerase: Tail Modifiers and Disease Implications

WIREs RNA, Volume 17, Issue 4, July/August 2026.
Schematic representation of the molecular interplay between PARN, telomerase‐associated, and the involvement of p53 in regulating telomere maintenance and genome stability. The top panel shows how normal PARN levels are involved in regulating p53 levels and balanced telomerase activity through their regulatory interaction with TERC and TERRA, thus ...
Sujitha Felicitus, Shalon Suzanne Pinto, Sai Samanvitha Madagundapalli Ramakrishna, Dechamma Pandyanada Nanjappa, Gunimala Chakraborty, Anirban Chakraborty   +5 more
wiley   +1 more source

Alternative Polyadenylation Mediates MicroRNA Regulation of Muscle Stem Cell Function

, 2012
SummaryPax3, a key myogenic regulator, is transiently expressed during activation of adult muscle stem cells, or satellite cells (SCs), and is also expressed in a subset of quiescent SCs (QSCs), but only in specific muscles.
Rando, Thomas A., Iori, Kevin, Quach, Navaline L., Liu, Ling, Prescott, Sara L., Edalati, Abdolhossein, Boutet, Stéphane C., Cheung, Tom H.   +7 more
core   +1 more source

High-Resolution RNA Maps Suggest Common Principles of Splicing and Polyadenylation Regulation by TDP-43

Cell Reports, 2017
Summary: Many RNA-binding proteins (RBPs) regulate both alternative exons and poly(A) site selection. To understand their regulatory principles, we developed expressRNA, a web platform encompassing computational tools for integration of iCLIP and RNA ...
Gregor Rot, Zhen Wang, Ina Huppertz, Miha Modic, Tina Lenče, Martina Hallegger, Nejc Haberman, Tomaž Curk, Christian von Mering, Jernej Ule   +9 more
doaj   +1 more source