Results 111 to 120 of about 30,645 (223)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation

, 2020
Alternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell ...
Bin Tian, James L. Manley, Mainul Hoque, Erdene Baljinnyam, Fangzheng Sun, Chi-Wei Lu, Dinghai Zheng, Koichi Ogami, Percy Luk Yeung, Larry C. Cheng   +9 more
core   +1 more source

Alternative Polyadenylation Dynamics During the Rice Blast Immune Response

Molecular Plant Pathology, Volume 27, Issue 7, July 2026.
In rice, infection by the blast fungus Magnaporthe oryzae triggers genome‐wide alternative polyadenylation (APA) dynamics, leading to widespread 3′ UTR shortening in stress‐responsive transcripts. This shortening enables immunity‐related genes to evade miRNA‐mediated suppression.
Dewei Yang, Xinyi Li, Haohua He, Niqing He, Qingshun Q. Li, Haihui Fu   +5 more
wiley   +1 more source

Alternative polyadenylation as a genetic regulatory mechanism to bridge genome to phenome in the context of appetitive behaviors.

, 2023
Energy is essential for life. On one end of the spectrum, over 1/3 of Americans live with obesity, which only occurs when excess energy is consumed and stored by the body.
Brutman, Julianna
core   +1 more source

Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4619-4639, July 2026.
Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska, Dorota Sołtys‐Kalina, Audrey Y.‐H. Teh   +2 more
wiley   +1 more source

Regulation of polyadenylation site choice in plant nuclear mRNA

Environmental and Experimental Botany
The polyadenylation machinery plays a critical role in the processing of pre-mRNA into mature mRNA. This process involves a large multiprotein complex that recognizes polyadenylation signals and determines the polyadenylation sites (PASs).
Wei Zeng, Xiutao Wang, Qiying Zhou, Shengli Jing   +3 more
doaj   +1 more source

Salt Stress Adaptations in Soybean Involve Alterations in Pre‐mRNA Processing

Plant, Cell &Environment, Volume 49, Issue 7, Page 4000-4014, July 2026.
ABSTRACT Salt stress can seriously affect plant survival. To adapt to salt stress, plants can alter gene expressions and/or pre‐mRNA processing patterns, or both. Previous studies could not comprehensively profile stress‐responsive pre‐mRNA processing patterns due to limitations in traditional sequencing technologies.
Shoudong Zhang, Zhixia Xiao, Ailin Liu, Dongpeng Ren, Shengjie Chen, Hanxue Zhang, Li Zhang, Zhili Wang, Jun Yang, Hon‐Ming Lam   +9 more
wiley   +1 more source

Alternative Polyadenylation sites of Gossypium purpurascens

Alternative Polyadenylation sites of Gossypium ...
Zhen Peng (17703885)
core   +1 more source

Alternative polyadenylation: Less than meets the eye [PDF]

, 2020
With the advances in deep-sequencing techniques over the last decade, the study of alternative cleavage and polyadenylation (APA) has shifted from individual gene to whole transcriptome analysis. Findings from such global studies have elevated APA to its
Jonathan Neve, André Furger
core  

The circadian clock shapes the Arabidopsis transcriptome by regulating alternative splicing and alternative polyadenylation

, 2020
The circadian clock in plants temporally coordinates biological processes throughout the day, synchronizing gene expression with diurnal environmental changes.
Yang, Y., Oztas, O., Li, Y., Sancar, A.
core   +1 more source