Results 131 to 140 of about 30,645 (223)
Ecology and Evolution, Volume 16, Issue 6, June 2026.This study sequenced and annotated the complete 17,230 bp mitochondrial genome of Ovophis makazayazaya, which contains 13 protein‐coding genes (PCGs), 2 rRNAs, 22 tRNAs, and a D‐loop region, with a significant AT bias (57.2%). Phylogenetic analyses confirmed its placement within Crotalinae, and all PCGs showed evidence of purifying selection (Ka/Ks < 1)
Yuheng Jiang, Yuhao Nie, Zhiqiang Ge
wiley +1 more source
Global analysis of regulatory divergence in the evolution of mouse alternative polyadenylation
Molecular Systems Biology, 2016 Alternative polyadenylation (APA), which is regulated by both cis‐elements and trans‐factors, plays an important role in post‐transcriptional regulation of eukaryotic gene expression.
Mei‐Sheng Xiao +5 more
doaj +1 more source
The Effect of Protein Tagging on Aggregation and Phase Separation
Journal of Cellular Biochemistry, Volume 127, Issue 6, June 2026.ABSTRACT Protein tags are widely used for purification, solubilization, detection, and imaging, yet they can substantially alter protein self‐assembly. This interference is particularly significant for intrinsically disordered proteins and low‐complexity domains, whose aggregation and phase separation are mediated by weak multivalent interactions that ...
Harunobu Saito, Kenji Sugase
wiley +1 more source
RNAs Associated With Bacterial Outer Membrane Vesicles: Structural Insights Into Surface Composition
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.This work uncovers a new layer of bacterial communication. We show that RNAs, aided by the Hfq RNA‐chaperone, are not only packed inside Gram negative Outer Membrane Vesicles (OMVs) but can also be embedded in their membranes. This suggests that bacteria may use surface‐exposed RNAs to directly interact with host cells. Overall, our results broaden the
Kevin Mosca +4 more
wiley +1 more source
Reverse Genetics of Orthoflaviviruses: Strategies for Constructing Functional or Infectious cDNA
Journal of Medical Virology, Volume 98, Issue 6, June 2026.ABSTRACT Reverse genetics (RG) systems have transformed RNA virus research by enabling the recovery of recombinant viruses entirely from cloned cDNA. These platforms allow precise, hypothesis‐driven manipulation of viral genomes and support systematic phenotypic analyses in vitro and in vivo.
Young‐Min Lee
wiley +1 more source
A different perspective on alternative cleavage and polyadenylation [PDF]
Nature Reviews Genetics, 2019 Chuan Xu, Jianzhi Zhang
openaire +2 more sources
MedComm, Volume 7, Issue 6, June 2026.We identified SRF as the key TF significantly associated with the malignant phenotype and poor prognosis of GBM. SRF forms a transcriptional complex with P54nrb via phase separation to upregulate the expression of OLFML3. OLFML3 activates ECs and promotes angiogenesis by degrading ECM, releasing proangiogenic factors, enhancing cell–cell adhesion, and ...
Zetao Chen +12 more
wiley +1 more source
MedComm, Volume 7, Issue 6, June 2026.To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr +37 more
wiley +1 more source
Alternative polyadenylation and its impact on cellular processes
, 2014 Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression ...
Akman Tuncer, Hesna Begüm +2 more
core +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.We generated Thy1‐Cre–driven GCaMP8 transgenic rats by mating Thy1‐Cre rats with knock‐in rats carrying a floxed GCaMP8‐STOP cassette in the β‐actin locus. Robust neuronal GCaMP8 expression enabled transcranial calcium imaging of the auditory cortex, establishing this model as a powerful tool for minimally invasive cortical macro‐imaging and functional
Manavu Tohmi +10 more
wiley +1 more source