Results 131 to 140 of about 725 (142)
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Alternative polyadenylation and the stress response
WIREs RNA, 2019AbstractThe cellular stress response is a universal mechanism necessary for the survival of all organisms. This multifaceted process is primarily driven by regulation of gene expression to produce an intracellular environment suitable for promoting cell survival and recovery.
Jason Sadek +4 more
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Plasmid, 2006
The soluble neuropilin-1 (sNRP-1) gene employs an extremely short dual function polyadenylation (pA) signal/stop codon that is efficient for termination of gene transcription and translation in vivo. However, the functionality and usefulness of this signal in regard to other genes is unknown.
Trevor J, McFarland +5 more
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The soluble neuropilin-1 (sNRP-1) gene employs an extremely short dual function polyadenylation (pA) signal/stop codon that is efficient for termination of gene transcription and translation in vivo. However, the functionality and usefulness of this signal in regard to other genes is unknown.
Trevor J, McFarland +5 more
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Quantifying alternative polyadenylation in RNAseq data with LABRAT
2021Alternative polyadenylation (APA) generates transcript isoforms that differ in their 3' UTR content and may therefore be subject to different regulatory fates. Although the existence of APA has been known for decades, quantification of APA isoforms from high-throughput RNA sequencing data has been difficult.
Austin E, Gillen +2 more
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Alternative Polyadenylation and Its Impact on Cellular Processes
MicroRNA, 2014Impact of mRNA processing and/or modifications has long been associated with gene expression regulation. Accumulating evidence shows alternative polyadenylation (APA), as an mRNA related process, to emerge as a widespread mechanism in gene expression regulation.
Hesna B, Akman, Ayse E, Erson-Bensan
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Alternative polyadenylation in the regulation and dysregulation of gene expression
Seminars in Cell & Developmental Biology, 2018Transcriptional control shapes a cell's transcriptome composition, but it is RNA processing that refines its expression. The untranslated regions (UTRs) of mRNA are hotspots for regulatory control. Features in these can impact mRNA stability, localisation and translation.
Rachael Emily, Turner +2 more
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Journal of Neurochemistry
Abstract Neurodegenerative diseases (NDDs) are one of the prevailing conditions characterized by progressive neuronal loss. Polyadenylation (PA) and alternative polyadenylation (APA) are the two main post‐transcriptional events that regulate neuronal gene expression and protein production.
Tarlan, Yeganeh Markid +7 more
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Abstract Neurodegenerative diseases (NDDs) are one of the prevailing conditions characterized by progressive neuronal loss. Polyadenylation (PA) and alternative polyadenylation (APA) are the two main post‐transcriptional events that regulate neuronal gene expression and protein production.
Tarlan, Yeganeh Markid +7 more
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Alternative polyadenylation and gene expression regulation in plants
WIREs RNA, 2010AbstractFunctioning as an essential step of pre‐mRNA processing, polyadenylation has been realized in recent years to play an important regulatory role during eukaryotic gene expression. Such regulation occurs mostly through the use of alternative polyadenylation (APA) sites and generates different transcripts with altered coding capacity for proteins ...
Denghui, Xing, Qingshun Quinn, Li
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Alternative polyadenylation at Mest
Imprinting, an epigenetic phenomenon where only one allele of a gene is expressed depending on its parental origin, plays a significant role in mammalian development. The sub-proximal MMU6 imprinting domain, particularly, includes the paternally expressed gene Mest and the maternally expressed genes Copg2 and Klf14. In addition to the mature mRNA, Mestopenaire +1 more source
Alternative Splicing and Alternative Polyadenylation in Moso Bamboo
2021Lianfeng Gu, Hangxiao Zhang, Jian Gao
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Analysis of tissue specificity of alternative polyadenylation sites
Proceedings of the 2022 5th International Conference on Algorithms, Computing and Artificial Intelligence, 2022openaire +2 more sources