Results 141 to 150 of about 30,645 (223)

FXR1‐Directed Alternative Splicing of MK5 Drives Hepatocellular Carcinoma Progression by Activating GSK3β Signaling

Cancer Science, Volume 117, Issue 6, Page 1580-1593, June 2026.
The RNA‐binding protein FXR1 promotes hepatocellular carcinoma (HCC) progression by driving alternative splicing of MK5 to generate an oncogenic isoform, MK5‐L, which activates the Wnt/β‐catenin pathway. Targeting FXR1 with an antisense oligonucleotide suppresses tumor growth in vivo, revealing a promising therapeutic strategy for HCC.
Yutong Li, Jin Xiang, Bin Cheng, Chenhao Li, Kai Wang, Ni Tang, Luyi Huang   +6 more
wiley   +1 more source

PEG10 polyadenylation.

, 2013
Shown is a schematic view of the 6570 bp long PEG10 transcript with a poly-A tail at its 3′-end. Shown is also the PEG10 mRNA 3′-end sequence with the two underlined canonical polyadenylation signal motifs.
Heiko Flammann (367928), Mathias Hafner (144687), Andreas Lux (367929), Heike Lux (367927)   +3 more
core   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, Volume 293, Issue 12, Page 3502-3527, June 2026.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Deciphering Estrus Expression in Gilts: The Role of Alternative Polyadenylation and LincRNAs in Reproductive Transcriptomics

Animals
The fertility rate and litter size of female pigs are critically affected by the expression of estrus. The objective of this study was to elucidate the regulatory mechanisms of estrus expression by analyzing the differential expression of genes and long ...
Mingzheng Liu, Jiahao Chen, Chunlei Zhang, Shuhan Liu, Xiaohuan Chao, Huan Yang, Asim Muhammad, Bo Zhou, Weiping Ao, Allan P. Schinckel   +9 more
doaj   +1 more source

Post‐transcriptional regulatory networks: The dynamic interplay of RNA‐binding proteins

The FEBS Journal, Volume 293, Issue 12, Page 3423-3441, June 2026.
Post‐transcriptional gene expression regulation is controlled by RNA‐binding proteins (RBPs), which influence many processes including splicing, localization, translation, and decay. Rather than acting alone, RBPs bind RNAs combinatorially, forming complex, context‐dependent regulatory networks.
Lena A. Street, Marko Jovanovic, Eugenio F. Fornasiero   +2 more
wiley   +1 more source

Additional file 9: of Alternative polyadenylation factors link cell cycle to migration

, 2018
Gene Ontology for alternative polyadenylation.
Mithun Mitra (2792155), Lois Nersesian (5899076), David Corney (34981), David Robinson (73947), Sandra Batista (5899082), Vinay Swamy (5899073), Hilary Coller (3706831), Daniel Taylor (486337), Wei Wang (17594), Elizabeth Johnson (11779), Aaron Ambrus (5899079), David Jelinek (4248520)   +11 more
core   +1 more source

Pre-messenger RNA cleavage factor I (CFIm): potential role in alternative polyadenylation during spermatogenesis

, 2009
A hallmark of male germ cell gene expression is the generation by alternative polyadenylation of cell-specific mRNAs, many of which utilize noncanonical A(A/U)UAAA-independent polyadenylation signals. Cleavage factor I (CFIm), a component of the pre-mRNA
Kilpatrick, Daniel L., Sartini, Becky L., Wang, Wei, Wang, Hang, Millette, Clarke F.   +4 more
core   +1 more source

Alternative Polyadenylation in Aging and Aging-Related Diseases

aging and disease
Aging is a major risk factor for a wide range of chronic diseases. Elucidating the molecular mechanisms underlying aging-associated disorders is essential for developing effective preventive and therapeutic strategies. Recent research has unveiled the regulatory roles of non-coding genomic regions.
Mengqi, Chen, Xiangyu, Zhu, Lejia, Hang, Zijie, Yan, Li, Xu, Fang, Liu, Qiong, Zhang, Jingjing, Huang   +7 more
openaire   +2 more sources

Prediction of mRNA polyadenylation sites in the human genome and Mathematical modeling of alternative polyadenylation

, 2007
Messenger RNA (mRNA) polyadenylation plays many important roles in the cell, such as transcription termination, mRNA stability and transportation, and mRNA translation in eukaryotic cells.
Cheng, Yiming
core  

3'UTR Mapping Reveals Alternative Polyadenylation in Right Ventricular Failure. [PDF]

Circ Res
Neupane R, Natarajan K, Suarez EE, Pownall HJ, Huang KL, Wagner EJ, Verma AK, Majji R, Yalamanchili HK, Guha A, Thandavarayan RA.   +10 more
europepmc   +1 more source