Results 31 to 40 of about 30,645 (223)
Alternative cleavage and polyadenylation: the long and short of it [PDF]
Trends in Biochemical Sciences, 2013 Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the 3' ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have elucidated the machinery responsible for the seemingly simple C/P reaction.
Bin, Tian, James L, Manley
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Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2014 The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld +6 more
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Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33 [PDF]
, 2014 Cleavage and polyadenylation specificity factor (CPSF) is the central component of the 3' processing machinery for polyadenylated mRNAs in metazoans: CPSF recognizes the polyadenylation signal AAUAAA, providing sequence specificity in both pre-mRNA ...
Zavolan, Mihaela +7 more
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Scientific Reports, 2021 Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRNA isoforms in 70% of human genes.
Hyeon-Mu Cho +7 more
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Polyadenylation: alternative lifestyles of the A‐rich (and famous?) [PDF]
The EMBO Journal, 2010 EMBO J 29 9, 1523–1536 (2010); published online March252010 [PMC free article] [PubMed] Alternative polyadenylation has a major function in gene expression and is often mediated through signals that lack canonical signatures. In this issue, Nunes et al (2010) uncover a new upstream A-rich sequence element that in conjunction with a strong U/GU-rich ...
Alexa M, Dickson, Jeffrey, Wilusz
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Template-switching artifacts resemble alternative polyadenylation
BMC Genomics, 2019 Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally ...
Zsolt Balázs +5 more
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Alterations in polyadenylation and its implications for endocrine disease
Frontiers in Endocrinology, 2013 IntroductionPolyadenylation is the process in which the pre-mRNA is cleaved at the poly(A) site and a poly(A) tail is added - a process necessary for normal mRNA formation.
Anders eRehfeld +3 more
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CFIm25 in Solid Tumors: Current Research Progress
Technology in Cancer Research & Treatment, 2020 Cleavage factor I m25 is a newly discovered solid tumor-related gene, however, its precise role in cancer pathogenesis has not yet been characterized.
Xiaojie Sun MD, PhD +4 more
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Biased alternative polyadenylation in human tissues [PDF]
Genome Biology, 2005 Abstract Background Alternative polyadenylation is one of the mechanisms in human cells that give rise to a variety of transcripts from a single gene. More than half of the human genes have multiple polyadenylation sites (poly(A) sites), leading to variable mRNA and protein products.
Zhang, Haibo, Lee, Ju Youn, Tian, Bin
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Global insights into alternative polyadenylation regulation [PDF]
RNA Biology, 2015 Alternative pre-mRNA processing greatly increases the coding capacity of the human genome and regulatory factors involved in RNA processing play critical roles in tissue development and maintenance. Indeed, abnormal functions of RNA processing factors have been associated with a wide range of human diseases from cancer to neurodegenerative disorders ...
Ranjan, Batra +2 more
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