Results 31 to 40 of about 3,647,679 (259)
Alternative Polyadenylation Determines the Functional Landscape of Inverted Alu Repeats
bioRxiv, 2023 Inverted Alu repeats (IRAlus) are abundantly found in the transcriptome, especially in introns and 3′ UTRs. Yet, the biological significance of 3′ UTR IRAlus remains largely unknown.
Jayoung Ku +9 more
semanticscholar +1 more source
Nature Communications, 2023 Nervous system development is associated with extensive regulation of alternative splicing (AS) and alternative polyadenylation (APA). AS and APA have been extensively studied in isolation, but little is known about how these processes are coordinated ...
Zhiping Zhang +3 more
semanticscholar +1 more source
Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR. [PDF]
PLoS ONE, 2015 About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that this coupling may be an intrinsic mechanism to directly regulate the host gene's expression ...
Ludwig Christian Hinske +7 more
doaj +1 more source
Regulation and function of alternative polyadenylation in development and differentiation
RNA Biology, 2023 Alternative processing of nascent mRNAs is widespread in eukaryotic organisms and greatly impacts the output of gene expression. Specifically, alternative cleavage and polyadenylation (APA) is a co-transcriptional molecular process that switches the ...
Lorenzo Gallicchio +3 more
semanticscholar +1 more source
Alternative polyadenylation [PDF]
Plant Signaling & Behavior, 2009 Based on comparative genome analyses, the increases in protein-coding gene number could not account for the increases of morphological and behavioral complexity of higher eukaryotes. Transcriptional regulations, alternative splicing and the involvement of non-coding RNA in gene expression regulations have been credited for the drastic increase of ...
Denghui, Xing, Qingshun Quinn, Li
openaire +2 more sources
Molecules, 2021 The neuronal Hu/ELAV-like proteins HuB, HuC and HuD are a class of RNA-binding proteins that are crucial for proper development and maintenance of the nervous system. These proteins bind to AU-rich elements (AREs) in the untranslated regions (3′-UTRs) of
Rebecca M. Sena +5 more
doaj +1 more source
Nature Genetics, 2021 Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3′
Lei Li +12 more
semanticscholar +1 more source
Global insights into alternative polyadenylation regulation [PDF]
RNA Biology, 2015 Alternative pre-mRNA processing greatly increases the coding capacity of the human genome and regulatory factors involved in RNA processing play critical roles in tissue development and maintenance. Indeed, abnormal functions of RNA processing factors have been associated with a wide range of human diseases from cancer to neurodegenerative disorders ...
Ranjan, Batra +2 more
openaire +2 more sources
Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2014 The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld +6 more
doaj +1 more source
PABPN1 regulates mRNA alternative polyadenylation to inhibit bladder cancer progression
Cell & Bioscience, 2023 Background About 10–20% of patients with bladder cancer (BC) progress to muscle-invasive diseases, of which the underlying key molecular events have yet to be addressed.
Liang Chen +8 more
semanticscholar +1 more source