Results 31 to 40 of about 725 (142)
Regulation of alternative polyadenylation by genomic imprinting [PDF]
Genes & Development, 2008 Maternally and paternally derived alleles can utilize different promoters, but allele-specific differences in cotranscriptional processes have not been reported. We show that alternative polyadenylation sites at a novel murine imprinted gene ( H13 ) are utilized in an allele-specific manner ...
Wood, Andrew J. +7 more
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CRISPRpas: programmable regulation of alternative polyadenylation by dCas9 [PDF]
Nucleic Acids Research, 2021 Abstract Most human protein-coding genes produce alternative polyadenylation (APA) isoforms that differ in 3′ UTR size or, when coupled with splicing, have variable coding sequences. APA is an important layer of gene expression program critical for defining cell identity.
Jihae Shin +6 more
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Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
Genome Biology, 2021 Background Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3′ ends.
Ankeeta Shah +3 more
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Alternative polyadenylation and RNA-binding proteins [PDF]
Journal of Molecular Endocrinology, 2016 Our understanding of the extent of microRNA-based gene regulation has expanded in an impressive pace over the past decade. Now, we are beginning to better appreciate the role of 3′-UTR (untranslated region) cis- elements which harbor not only microRNA but also RNA-binding protein (RBP ...
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Insects, 2022 During the messenger RNA (mRNA) maturation process, RNA polyadenylation is a key step, and is coupled to the termination of transcription. Various cis-acting elements near the cleavage site and their binding factors would affect the process of ...
Liying Fang +4 more
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Conservation of alternative polyadenylation patterns in mammalian genes [PDF]
BMC Genomics, 2006 Abstract Background Alternative polyadenylation is a widespread mechanism contributing to transcript diversity in eukaryotes. Over half of mammalian genes are alternatively polyadenylated. Our understanding of poly(A) site evolution is limited by the lack of a reliable identification of conserved, equivalent poly(A ...
Ara, Takeshi +4 more
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RNA regulatory elements and polyadenylation in plants
Frontiers in Plant Science, 2012 Alternative poly(A) site choice (also known as alternative polyadenylation, or APA) has the potential to affect gene expression in qualitative and quantitative ways. Alternative polyadenylation may affect as many as 82% of all expressed genes in a plant.
Arthur G. Hunt
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Frontiers in Genetics, 2022 Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that most transcripts in humans undergo alternative splicing and alternative polyadenylation.
Ryan Lusk +8 more
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BMC Medical Genomics, 2019 Background Transcriptome wide changes have been assessed extensively during the progression of neurodegenerative diseases. Alternative polyadenylation (APA) occurs in over 70% of human protein coding genes and it has recently been recognised as a ...
Radhika Patel +4 more
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Regulation and function of alternative polyadenylation in development and differentiation
RNA Biology, 2023 Alternative processing of nascent mRNAs is widespread in eukaryotic organisms and greatly impacts the output of gene expression. Specifically, alternative cleavage and polyadenylation (APA) is a co-transcriptional molecular process that switches the polyadenylation site (PAS) at which a nascent mRNA is cleaved, resulting in mRNA isoforms with different
Lorenzo Gallicchio +3 more
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