Results 11 to 20 of about 30,645 (223)

Alternative Polyadenylation Blooms [PDF]

Developmental Cell, 2010
Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
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Regulation of alternative polyadenylation by genomic imprinting [PDF]

Genes & Development, 2008
Maternally and paternally derived alleles can utilize different promoters, but allele-specific differences in cotranscriptional processes have not been reported. We show that alternative polyadenylation sites at a novel murine imprinted gene ( H13 ) are utilized in an allele-specific manner ...
Wood, Andrew J., Schulz, Reiner, Woodfine, Kathryn, Koltowska, Katarzyna, Beechey, Colin V., Peters, Jo, Bourc'his, Deborah, Oakey, Rebecca J.   +7 more
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AltTrans: Transcript pattern variants annotated for both alternative splicing and alternative polyadenylation

BMC Bioinformatics, 2006
Background The three major mechanisms that regulate transcript formation involve the selection of alternative sites for transcription start (TS), splicing, and polyadenylation.
Lopez Fabrice, Gopalakrishnan Chellappa, Kumanduri Vasudev, Riethoven Jean-Jack, Le Texier Vincent, Gautheret Daniel, Thanaraj Thangavel Alphonse   +6 more
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Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation [PDF]

Cell, 2010
The emerging discoveries on the link between polyadenylation and disease states underline the need to fully characterize genome-wide polyadenylation states. Here, we report comprehensive maps of global polyadenylation events in human and yeast generated using refinements to the Direct RNA Sequencing technology.
Ozsolak, Fatih, Kapranov, Philipp, Foissac, Sylvain, Kim, Sang Woo, Fishilevich, Elane, Monaghan, A. Paula, John, Bino, Milos, Patrice M.   +7 more
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Interplay between Alternative Splicing and Alternative Polyadenylation Defines the Expression Outcome of the Plant Unique OXIDATIVE TOLERANT-6 Gene

Scientific Reports, 2017
Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li, Zhaoyang Liu, Wenjia Lu, Man Liu   +3 more
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The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex

Molecules, 2021
The neuronal Hu/ELAV-like proteins HuB, HuC and HuD are a class of RNA-binding proteins that are crucial for proper development and maintenance of the nervous system. These proteins bind to AU-rich elements (AREs) in the untranslated regions (3′-UTRs) of
Rebecca M. Sena, Jeffery L. Twiss, Amy S. Gardiner, Michela Dell’Orco, David N. Linsenbardt, Nora I. Perrone-Bizzozero   +5 more
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Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR. [PDF]

PLoS ONE, 2015
About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that this coupling may be an intrinsic mechanism to directly regulate the host gene's expression ...
Ludwig Christian Hinske, Pedro A F Galante, Elisabeth Limbeck, Patrick Möhnle, Raphael B Parmigiani, Lucila Ohno-Machado, Anamaria A Camargo, Simone Kreth   +7 more
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Alternative cleavage and polyadenylation in health and disease

Nature Reviews Genetics, 2019
Most human genes have multiple sites at which RNA 3' end cleavage and polyadenylation can occur, enabling the expression of distinct transcript isoforms under different conditions. Novel methods to sequence RNA 3' ends have generated comprehensive catalogues of polyadenylation (poly(A)) sites; their analysis using innovative computational methods has ...
Andreas J. Gruber, Mihaela Zavolan
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Extensive alternative polyadenylation during zebrafish development [PDF]

Genome Research, 2012
The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3′ untranslated regions (3′ UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-seq) to map poly(A) sites at eight developmental stages and tissues in the zebrafish.
Ulitsky, Igor, Shkumatava, Alena, Jan, Calvin H., Subtelny, Alexander Orest, Koppstein, David Neal Pira, Bell, George W., Sive, Hazel L., Bartel, David   +7 more
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A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study [PDF]

Nature Communications
Alternative polyadenylation plays an important role in cancer initiation and progression; however, current transcriptome-wide association studies mostly ignore alternative polyadenylation when identifying putative cancer susceptibility genes.
Hui Chen, Zeyang Wang, Lihai Gong, Qixuan Wang, Wenyan Chen, Jia Wang, Xuelian Ma, Ruofan Ding, Xing Li, Xudong Zou, Mireya Plass, Cheng Lian, Ting Ni, Gong-Hong Wei, Wei Li, Lin Deng, Lei Li   +16 more
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