Results 11 to 20 of about 3,647,679 (259)
Alternative polyadenylation of mRNA precursors [PDF]
Nature Reviews Molecular Cell Biology, 2016 Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation.
Bin Tian, J. Manley
semanticscholar +5 more sources
Alternative Polyadenylation in Human Diseases [PDF]
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang +2 more
doaj +3 more sources
APC mutations dysregulate alternative polyadenylation in cancer [PDF]
Genome BiologyBackground Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood.
Austin M. Gabel +4 more
doaj +4 more sources
Context-specific regulation and function of mRNA alternative polyadenylation
Nature Reviews Molecular Cell Biology, 2022 Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of alternative 3′ UTR isoforms is highly cell type specific and is further controlled in a ...
Sibylle Mitschka, C. Mayr
semanticscholar +3 more sources
Template-switching artifacts resemble alternative polyadenylation [PDF]
BMC Genomics, 2019 Background Alternative polyadenylation is commonly examined using cDNA sequencing, which is known to be affected by template-switching artifacts. However, the effects of such template-switching artifacts on alternative polyadenylation are generally ...
Zsolt Balázs +5 more
doaj +4 more sources
Alternative polyadenylation regulation: insights from sequential polyadenylation
Transcription, 2022 The processing of the proximal and distal poly(A) sites in alternative polyadenylation (APA) has long been thought to independently occur on pre-mRNAs during transcription.
Peng Tang, Yu Zhou
semanticscholar +3 more sources
Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation [PDF]
Cell, 2010 The emerging discoveries on the link between polyadenylation and disease states underline the need to fully characterize genome-wide polyadenylation states. Here, we report comprehensive maps of global polyadenylation events in human and yeast generated using refinements to the Direct RNA Sequencing technology.
Ozsolak, Fatih +7 more
openaire +5 more sources
Alternative Polyadenylation: Methods, Findings, and Impacts
Genomics, Proteomics & Bioinformatics, 2017 Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3â² ends originate from distinct polyadenylation sites of a single gene, is emerging as a mechanism widely used to regulate gene expression.
Wei Chen +5 more
doaj +3 more sources
CFIm25 links alternative polyadenylation to glioblastoma tumour suppression [PDF]
Nature, 2014 The global shortening of messenger RNAs through alternative polyadenylation (APA) that occurs during enhanced cellular proliferation represents an important, yet poorly understood mechanism of regulated gene expression. The 3' untranslated region (UTR) truncation of growth-promoting mRNA transcripts that relieves intrinsic microRNA- and AU-rich-element-
Masamha, Chioniso P. +7 more
openaire +4 more sources
A Deep Neural Network for Predicting and Engineering Alternative Polyadenylation.
Cell, 2019 Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells. Here, we use deep learning to predict APA from DNA sequence alone.
Nicholas Bogard +3 more
semanticscholar +3 more sources