Results 11 to 20 of about 725 (142)
Coupling of alternative splicing and alternative polyadenylation
Acta Biochimica et Biophysica SinicaRNA splicing and 3′-cleavage and polyadenylation (CPA) are essential processes for the maturation of RNA. There have been extensive independent studies of these regulated processing events, including alternative ...
Zhang Xueying, Liu Feiyan, Zhou Yu
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Alternative Polyadenylation: Methods, Findings, and Impacts
Genomics, Proteomics & Bioinformatics, 2017 Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3â² ends originate from distinct polyadenylation sites of a single gene, is emerging as a mechanism widely used to regulate gene expression.
Wei Chen +5 more
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Transcriptional activity regulates alternative cleavage and polyadenylation
Molecular Systems Biology, 2011 Genes containing multiple pre‐mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs).
Zhe Ji +6 more
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Editorial: Alternative Polyadenylation in Development and Disease
Frontiers in Genetics, 2022 Athma A. Pai, Yang I. Li, Paolo Provero
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Alternative Polyadenylation Blooms [PDF]
Developmental Cell, 2010 Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
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Alternative polyadenylation of mRNA precursors [PDF]
Nature Reviews Molecular Cell Biology, 2016 Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct 3' termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all eukaryotic species and is recognized as a major mechanism of gene regulation. APA exhibits tissue specificity and is important for cell proliferation and differentiation.
Bin, Tian, James L, Manley
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Alternative polyadenylation of cyclooxygenase-2 [PDF]
Nucleic Acids Research, 2005 A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased transcriptional activity accounts for only part of the upregulation of COX-2, we chose to explore other RNA ...
Hall-Pogar, Tyra +3 more
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Mechanisms and Consequences of Alternative Polyadenylation [PDF]
Molecular Cell, 2011 Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode multiple mRNA transcripts. In some cases, this changes the mRNA coding potential; in other cases, the code remains unchanged but the 3' UTR length is ...
Di Giammartino, Dafne Campigli +2 more
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Alternative Polyadenylation: Another Foe in Cancer [PDF]
Molecular Cancer Research, 2016 Abstract Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer
Erson-Bensan, Ayse Elif, Can, Tolga
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Alternative cleavage and polyadenylation: the long and short of it [PDF]
Trends in Biochemical Sciences, 2013 Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the 3' ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have elucidated the machinery responsible for the seemingly simple C/P reaction.
Bin, Tian, James L, Manley
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