Results 21 to 30 of about 3,647,679 (259)

Transcriptional activity regulates alternative cleavage and polyadenylation

Molecular Systems Biology, 2011
Genes containing multiple pre‐mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3′ untranslated regions (UTRs).
Zhe Ji, Wenting Luo, Wencheng Li, Mainul Hoque, Zhenhua Pan, Yun Zhao, Bin Tian   +6 more
doaj   +3 more sources

Alternative Polyadenylation Blooms [PDF]

Developmental Cell, 2010
Alternative polyadenylation generates mRNAs with 3' untranscribed regions of different lengths, often affecting transcript stability. Hornyik et al., in this issue of Developmental Cell, and Liu et al. now demonstrate a role for alternative polyadenylation in gene silencing and the regulation of flowering time in Arabidopsis thaliana.
Rosonina, Emanuel, Manley, James L.
openaire   +2 more sources

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Nature Communications, 2023
Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook APA in nominating susceptibility genes.
Ya Cui, F. Arnold, Fanglue Peng, Dan Wang, J. Li, S. Michels, Eric J. Wagner, A. L. La Spada, Wei Li   +8 more
semanticscholar   +1 more source

Editorial: Alternative Polyadenylation in Development and Disease

Frontiers in Genetics, 2022
Athma A. Pai, Yang I. Li, Paolo Provero
doaj   +3 more sources

CPSF6 regulates alternative polyadenylation and proliferation of cancer cells through phase separation.

Cell Reports, 2023
Cancer cells usually exhibit shortened 3' untranslated regions (UTRs) due to alternative polyadenylation (APA) to promote cell proliferation and migration. Upregulated CPSF6 leads to a systematic prolongation of 3' UTRs, but CPSF6 expression in tumors is
Susu Liu, Runze Wu, Liutao Chen, Ke Deng, Xin Ou, Xin Lu, Mengxia Li, Chao Liu, Shangwu Chen, Yonggui Fu, Anlong Xu   +10 more
semanticscholar   +1 more source

Alternative polyadenylation of cyclooxygenase-2 [PDF]

Nucleic Acids Research, 2005
A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased transcriptional activity accounts for only part of the upregulation of COX-2, we chose to explore other RNA ...
Hall-Pogar, Tyra, Zhang, Haibo, Tian, Bin, Lutz, Carol S.   +3 more
openaire   +2 more sources

Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites

Science Advances, 2023
Alternative polyadenylation (APA) creates distinct transcripts from the same gene by cleaving the pre-mRNA at poly(A) sites that can lie within the 3′ untranslated region (3′UTR), introns, or exons.
Nicola de Prisco, Caitlin Ford, Nathan D. Elrod, Winston Lee, Lauren C. Tang, Kai-Lieh Huang, Ai Lin, Ping Ji, V. Jonnakuti, Lia Boyle, Maximilian Cabaj, Salvatore Botta, K. Õunap, K. Reinson, M. Wojcik, J. Rosenfeld, W. Bi, K. Tveten, Trine E Prescott, T. Gerstner, A. Schroeder, C. Fong, Jaya K George-Abraham, Catherine A. Buchanan, Andrea Hanson-Khan, J. Bernstein, A. Nella, Wendy K. Chung, Vicky L Brandt, M. Jovanović, Kimara L. Targoff, H. Yalamanchili, Eric J. Wagner, Vincenzo A. Gennarino   +33 more
semanticscholar   +1 more source

mRNA 3’UTR lengthening by alternative polyadenylation attenuates inflammatory responses and correlates with virulence of Influenza A virus

Nature Communications, 2023
Changes of mRNA 3’UTRs by alternative polyadenylation (APA) have been associated to numerous pathologies, but the mechanisms and consequences often remain enigmatic. By combining transcriptomics, proteomics and recombinant viruses we show that all tested
Valter Bergant, D. Schnepf, N. de Andrade Krätzig, P. Hubel, C. Urban, T. Engleitner, R. Dijkman, B. Ryffel, K. Steiger, P. Knolle, G. Kochs, R. Rad, P. Staeheli, A. Pichlmair   +13 more
semanticscholar   +1 more source

Alternative Polyadenylation: Another Foe in Cancer [PDF]

Molecular Cancer Research, 2016
Abstract Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer
Erson-Bensan, Ayse Elif, Can, Tolga
openaire   +3 more sources

Stress responses of plants through transcriptome plasticity by mRNA alternative polyadenylation

Molecular Horticulture, 2023
The sessile nature of plants confines their responsiveness to changing environmental conditions. Gene expression regulation becomes a paramount mechanism for plants to adjust their physiological and morphological behaviors.
Jiawen Zhou, Q. Li
semanticscholar   +1 more source