Results 21 to 30 of about 30,645 (223)

HIV-1 infection regulates gene expression by altering alternative polyadenylation correlated with CPSF6 and CPSF5 redistribution [PDF]

mBio
HIV-1 viral core transport to the nucleus, an early infection event, triggers the redistribution of cleavage and polyadenylation specificity factors (CPSF) 5 and CPSF6 to nuclear speckles, forming puncta-like structures.
Charlotte Luchsinger, Annie Zhi Dai, Hari Yalamanchili, Aiswarya Balakrishnan, Kai-Lieh Huang, Cinzia Bertelli, Bin Cui, Ramon Lorenzo-Redondo, Eric J. Wagner, Felipe Diaz-Griffero   +9 more
doaj   +2 more sources

Alternative 3′ UTR polyadenylation is disrupted in the rNLS8 mouse model of ALS/FTLD

Molecular Brain
Recent research has highlighted widespread dysregulation of alternative polyadenylation in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP).
Randall J. Eck, Paul N. Valdmanis, Nicole F. Liachko, Brian C. Kraemer   +3 more
doaj   +2 more sources

Editorial: Alternative Polyadenylation in Development and Disease

Frontiers in Genetics, 2022
Athma A. Pai, Yang I. Li, Paolo Provero
doaj   +3 more sources

APC mutations dysregulate alternative polyadenylation in cancer

Genome Biology
Background Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood.
Austin M. Gabel, Andrea E. Belleville, James D. Thomas, Jose Mario Bello Pineda, Robert K. Bradley   +4 more
doaj   +3 more sources

Mechanisms and Consequences of Alternative Polyadenylation [PDF]

Molecular Cell, 2011
Alternative polyadenylation (APA) is emerging as a widespread mechanism used to control gene expression. Like alternative splicing, usage of alternative poly(A) sites allows a single gene to encode multiple mRNA transcripts. In some cases, this changes the mRNA coding potential; in other cases, the code remains unchanged but the 3' UTR length is ...
Di Giammartino, Dafne Campigli, Nishida, Kensei, Manley, James L.   +2 more
openaire   +2 more sources

Alternative polyadenylation of cyclooxygenase-2 [PDF]

Nucleic Acids Research, 2005
A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased transcriptional activity accounts for only part of the upregulation of COX-2, we chose to explore other RNA ...
Hall-Pogar, Tyra, Zhang, Haibo, Tian, Bin, Lutz, Carol S.   +3 more
openaire   +2 more sources

The landscape of alternative polyadenylation in single cells of the developing mouse embryo

Nature Communications, 2021
Alternative polyadenylation regulates localization, half-life and translation of mRNA isoforms. Here the authors investigate alternative polyadenylation using single cell RNA sequencing data from mouse embryos and identify 3’-UTR isoforms that are ...
Vikram Agarwal, Sereno Lopez-Darwin, David R. Kelley, Jay Shendure   +3 more
doaj   +1 more source

NUDT21 Drives T-Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation. [PDF]

Adv Sci (Weinh)
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Qiu C, Wang J, Li Z, Ji Q, Zhang H, Zhang Q, Zhang S, Yu J, Tao Y, Wu Y, Shi C, Zai Z, Zhang Z, Li Y, Bai Z, Hu S, Pan J, Yang Y, Wu S.   +18 more
europepmc   +2 more sources

Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma

Frontiers in Cell and Developmental Biology, 2021
Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism required for cleavage and polyadenylation (CPA) of the 3′ untranslated region (3′ UTR) of mRNAs.
Shi-lu Chen, Shi-lu Chen, Zhong-xu Zhu, Xia Yang, Xia Yang, Li-li Liu, Li-li Liu, Yang-fan He, Yang-fan He, Ming-ming Yang, Ming-ming Yang, Xin-yuan Guan, Xin Wang, Xin Wang, Jing-ping Yun, Jing-ping Yun   +15 more
doaj   +1 more source

Alternative Polyadenylation: Another Foe in Cancer [PDF]

Molecular Cancer Research, 2016
Abstract Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer
Erson-Bensan, Ayse Elif, Can, Tolga
openaire   +3 more sources