Results 21 to 30 of about 725 (142)
Regulation of alternative splicing and polyadenylation in neurons
Life Science Alliance, 2023 Cell-type–specific gene expression is a fundamental feature of multicellular organisms and is achieved by combinations of regulatory strategies. Although cell-restricted transcription is perhaps the most widely studied mechanism, co-transcriptional and post-transcriptional processes are also central to the spatiotemporal control of gene functions.
Seungjae Lee, Joseph I Aubee, Eric C Lai
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Biased alternative polyadenylation in human tissues [PDF]
Genome Biology, 2005 Abstract Background Alternative polyadenylation is one of the mechanisms in human cells that give rise to a variety of transcripts from a single gene. More than half of the human genes have multiple polyadenylation sites (poly(A) sites), leading to variable mRNA and protein products.
Zhang, Haibo, Lee, Ju Youn, Tian, Bin
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Driving glioblastoma growth by alternative polyadenylation [PDF]
Cell Research, 2014 Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.
Ting, Han, John K, Kim
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The contribution of alternative polyadenylation to the cancer phenotype [PDF]
Carcinogenesis, 2017 Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as alternative polyadenylation (APA ...
Chioniso P Masamha, Eric J Wagner
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Polyadenylation: alternative lifestyles of the A‐rich (and famous?) [PDF]
The EMBO Journal, 2010 EMBO J 29 9, 1523–1536 (2010); published online March252010 [PMC free article] [PubMed] Alternative polyadenylation has a major function in gene expression and is often mediated through signals that lack canonical signatures. In this issue, Nunes et al (2010) uncover a new upstream A-rich sequence element that in conjunction with a strong U/GU-rich ...
Alexa M, Dickson, Jeffrey, Wilusz
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Global insights into alternative polyadenylation regulation [PDF]
RNA Biology, 2015 Alternative pre-mRNA processing greatly increases the coding capacity of the human genome and regulatory factors involved in RNA processing play critical roles in tissue development and maintenance. Indeed, abnormal functions of RNA processing factors have been associated with a wide range of human diseases from cancer to neurodegenerative disorders ...
Ranjan, Batra +2 more
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CFIm25 in Solid Tumors: Current Research Progress
Technology in Cancer Research & Treatment, 2020 Cleavage factor I m25 is a newly discovered solid tumor-related gene, however, its precise role in cancer pathogenesis has not yet been characterized.
Xiaojie Sun MD, PhD +4 more
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Alternative polyadenylation [PDF]
Plant Signaling & Behavior, 2009 Based on comparative genome analyses, the increases in protein-coding gene number could not account for the increases of morphological and behavioral complexity of higher eukaryotes. Transcriptional regulations, alternative splicing and the involvement of non-coding RNA in gene expression regulations have been credited for the drastic increase of ...
Denghui, Xing, Qingshun Quinn, Li
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Scientific Reports, 2017 Pre-mRNA alternative splicing and alternative polyadenylation have been implicated to play important roles during eukaryotic gene expression. However, much remains unknown regarding the regulatory mechanisms and the interactions of these two processes in
Qingshun Q. Li +3 more
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BMC Bioinformatics, 2006 Background The three major mechanisms that regulate transcript formation involve the selection of alternative sites for transcription start (TS), splicing, and polyadenylation.
Lopez Fabrice +6 more
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