Improved annotation of 3' untranslated regions and complex loci by combination of strand-specific direct RNA sequencing, RNA-seq and ESTs [PDF]
, 2014 The reference annotations made for a genome sequence provide the framework for all subsequent analyses of the genome. Correct and complete annotation in addition to the underlying genomic sequence is particularly important when interpreting the results ...
Junfang Song +29 more
core +1 more source
RNA Binding Proteins that Control Human Papillomavirus Gene Expression
Biomolecules, 2015 The human papillomavirus (HPV) life cycle is strictly linked to the differentiation program of the infected mucosal epithelial cell. In the basal and lower levels of the epithelium, early genes coding for pro-mitotic proteins and viral replication ...
Naoko Kajitani, Stefan Schwartz
doaj +1 more source
Functional characterization of Ysh1p, the yeast endonuclease involved in 3" end processing and in transcription termination of RNA polymerase II transcripts [PDF]
, 2008 Eukaryotic RNA polymerase II (RNAP II) is involved in the synthesis of two major classes of transcripts: messenger RNAs (mRNAs) and small nuclear and small nucleolar RNAs.
Garas, Monika
core +1 more source
Alternative poladenylation of tumor suppressor genes in small intestinal neuroendocrine tumors
Frontiers in Endocrinology, 2014 The tumorigenesis of small intestinal neuroendocrine tumors is poorly understood. Recent studies have associated alternative polyadenylation with proliferation, cell transformation and cancer.
Anders eRehfeld +6 more
doaj +1 more source
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation
Cell Reports, 2021 Summary: Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals mineralize.
Olga Gewartowska +16 more
doaj +1 more source
Mitochondrial Polyadenylation Is a One-Step Process Required for mRNA Integrity and tRNA Maturation. [PDF]
PLoS Genetics, 2016 Polyadenylation has well characterised roles in RNA turnover and translation in a variety of biological systems. While polyadenylation on mitochondrial transcripts has been suggested to be a two-step process required to complete translational stop codons,
Ana Bratic +8 more
doaj +1 more source
Transcription regulation of the Escherichia coli pcnB gene coding for poly(A) polymerase I: roles of ppGpp, DksA and sigma factors [PDF]
, 2010 Poly(A) polymerase I (PAP I), encoded by the pcnB gene, is a major enzyme responsible for RNA polyadenylation in Escherichia coli, a process involved in the global control of gene expression in this bacterium through inXuencing the rate of transcript ...
Grzegorz Węgrzyn +11 more
core +1 more source
A novel cause of DKC1‐related bone marrow failure: Partial deletion of the 3′ untranslated region
eJHaem, 2021 Telomere biology disorders (TBDs), including dyskeratosis congenita (DC), are a group of rare inherited diseases characterized by very short telomeres. Mutations in the components of the enzyme telomerase can lead to insufficient telomere maintenance in ...
Jonathan W. Arthur +14 more
doaj +1 more source
Specificity factors in cytoplasmic polyadenylation [PDF]
, 2013 Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development.
Hedda A. Meijer (7645400) +2 more
core +2 more sources
Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements. [PDF]
Genes & Development, 1994 In the cytoplasm of oocytes and early embryos, addition of poly(A) to mRNAs can activate their translation. We demonstrate that despite many differences between poly(A) addition in the cytoplasm and nucleus, these two forms of polyadenylation may involve identical trans-acting factors.
A, Bilger +3 more
openaire +2 more sources