Aging Alters mRNA Processing in the Mouse Ovary [PDF]
CellsAging in females affects the ovaries before any other organ. This has a significant impact on women’s health. Aging results in the gradual depletion of ovarian follicles and a decline in oocyte quality.
Kevin Vo +4 more
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eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production [PDF]
NucleusThe eukaryotic translation initiation factor eIF4E acts as a multifunctional factor that simultaneously influences mRNA processing, export, and translation in many organisms.
Jean-Clément Mars +2 more
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Assembly and regulation of the mammalian mRNA processing body [PDF]
PLoS ONE, 2023 Messenger RNA processing bodies (P-bodies) are cytoplasmic membrane-free organelles that contain proteins involved in mRNA silencing, storage and decay.
Donald B. Bloch +3 more
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Parvovirus RNA Processing: Compact Genomic Organization and Unique Alternative mRNA Processing Mechanisms [PDF]
VirusesParvoviruses have compact genomic organizations with overlapping open reading frames and thus utilize alternative RNA processing strategies, alternative splicing, alternative polyadenylation, and alternative translation mechanisms to generate a range of ...
Lisa K. Uhl, Olufemi O. Fasina
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Mitochondrial mRNA Processing in the Chlorophyte Alga Pediastrum duplex and Streptophyte Alga Chara vulgaris Reveals an Evolutionary Branch in Mitochondrial mRNA Processing [PDF]
Plants, 2021 Mitochondria carry the remnant of an ancestral bacterial chromosome and express those genes with a system separate and distinct from the nucleus. Mitochondrial genes are transcribed as poly-cistronic primary transcripts which are post-transcriptionally ...
Grayson C. R. Proulex +3 more
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Replicative aging in yeast involves dynamic intron retention patterns associated with mRNA processing/export and protein ubiquitination [PDF]
Microbial CellSaccharomyces cerevisiae (baker´s yeast) has yielded relevant in-sights into some of the basic mechanisms of organismal aging. Among these are genomic instability, oxidative stress, caloric restriction and mitochondrial dysfunction.
Jesús Gómez-Montalvo +4 more
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Clinically relevant benzoxaboroles inhibit mRNA processing in Trypanosoma brucei [PDF]
BMC Research Notes, 2022 Objective The cleavage and polyadenylation endonuclease CPSF73 is thought to be the target of the anti-trypanosomal benzoxaboroles AN7973, acoziborole and AN11736. We previously showed that AN7973 inhibits mRNA processing.
Albina Waithaka, Christine Clayton
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Multipurpose RNA maturation factors dysregulate multiple mRNA processing steps simultaneously and provide new therapeutic opportunities [PDF]
RNA BiologymRNAs undergo a series of chemical modifications to become competent for nuclear export and translation. This is referred to as mRNA maturation or processing and includes capping, splicing, and 3’end formation.
Sunirmal Paira, Katherine L. B. Borden
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Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing [PDF]
Molecular Cell, 2022 Nicole M Martinez +2 more
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Regulation of gene expression in trypanosomatids: living with polycistronic transcription [PDF]
Open Biology, 2019 In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and ...
Christine Clayton
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