Results 41 to 50 of about 3,806,370 (293)
Rrp47p is an exosome-associated protein required for the 3 ' processing of stable RNAs [PDF]
, 2003 Related exosome complexes of 3'-->5' exonucleases are present in the nucleus and the cytoplasm. Purification of exosome complexes from whole-cell lysates identified a Mg2+-labile factor present in substoichiometric amounts. This protein was identified
Tollervey, D +4 more
core +1 more source
Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis
eLife, 2022 3′ end formation of most eukaryotic mRNAs is dependent on the assembly of a ~1.5 MDa multiprotein complex, that catalyzes the coupled reaction of pre-mRNA cleavage and polyadenylation. In mammals, the cleavage and polyadenylation specificity factor (CPSF)
Lena Maria Muckenfuss +4 more
doaj +1 more source
Ovule identity mediated by pre-mRNA processing in Arabidopsis. [PDF]
PLoS Genetics, 2018 Ovules are fundamental for plant reproduction and crop yield as they are the precursors of seeds. Therefore, ovule specification is a critical developmental program. In Arabidopsis thaliana, ovule identity is redundantly conferred by the homeotic D-class
Encarnación Rodríguez-Cazorla +7 more
doaj +1 more source
Viruses, 2013 Nuclear mRNA export is a highly complex and regulated process in cells. Cellular transcripts must undergo successful maturation processes, including splicing, 5'-, and 3'-end processing, which are essential for assembly of an export competent ...
Adrian Whitehouse +3 more
doaj +1 more source
3 '-processing of yeast tRNA(Trp) precedes 5 '-processing [PDF]
, 2003 Previous analyses of eukaryotic pre-tRNAs processing have reported that 5'-cleavage by RNase P precedes 3'-maturation. Here we report that in contrast to all other yeast tRNAs analyzed to date, tRNA(Trp) undergoes 3'-maturation prior to 5'-cleavage ...
Tollervey, D, Kufel, J
core +1 more source
Notch mRNA expression in Drosophila embryos is negatively regulated at the level of mRNA 3' processing. [PDF]
PLoS ONE, 2009 Notch receptor regulates differentiation of almost all tissues and organs during animal development. Many mechanisms function at the protein level to finely regulate Notch activity.
Andrew K Shepherd +2 more
doaj +1 more source
Transcriptional termination enhances protein expression in human cells [PDF]
, 2009 Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal and, often, a downstream terminator sequence. Termination is triggered following recognition of the pA signal by Pol II and subsequent pre-mRNA cleavage ...
Proudfoot, Nicholas J +4 more
core +1 more source
MicroorganismsThe coordination between transcription and mRNA processing is essential for eukaryotic gene regulation, yet the structural basis of this coupling remains poorly understood in Entamoeba histolytica, the protozoan parasite responsible for amoebiasis.
Juan David Ospina-Villa +6 more
doaj +1 more source
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.
PLoS Pathogens, 2018 Kinetoplastid parasites-trypanosomes and leishmanias-infect millions of humans and cause economically devastating diseases of livestock, and the few existing drugs have serious deficiencies.
Daniela Begolo +11 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source