Results 51 to 60 of about 3,806,370 (293)

Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33 [PDF]

, 2014
Cleavage and polyadenylation specificity factor (CPSF) is the central component of the 3' processing machinery for polyadenylated mRNAs in metazoans: CPSF recognizes the polyadenylation signal AAUAAA, providing sequence specificity in both pre-mRNA ...
Zavolan, Mihaela, Wahle, Elmar, Gruber, Andreas R., Kühn, Uwe, Schönemann, Lars, Schäfer, Peter, Keller, Walter, Martin, Georges   +7 more
core   +1 more source

Nuclear mRNA export

Acta Biochimica et Biophysica Sinica
In eukaryotic cells, gene expression begins with transcription in the nucleus, followed by the maturation of messenger RNAs (mRNAs). These mRNA molecules are then exported to the cytoplasm through the nuclear pore ...
Chen Suli, Jiang Qingyi, Fan Jing, Cheng Hong   +3 more
doaj   +1 more source

RNA methylation in nuclear pre‐mRNA processing [PDF]

WIREs RNA, 2018
Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA).
Covelo‐Molares, Helena, Bartosovic, Marek, Vanacova, Stepanka   +2 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Regulation of processing body formation in the budding yeast "Saccharomyces cerevisiae" [PDF]

, 2014
The life cycle of mRNA, from transcription to decay, is a tightly regulated biological process. mRNA is an essential molecule that the cell utilizes to alter gene expression. Degradation is one process through which the cell can regulate mRNA levels.
Weidner, Julie
core   +1 more source

Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation. [PDF]

PLoS ONE, 2009
BACKGROUND:Metazoan replication-dependent histone mRNAs terminate in a conserved stem-loop structure rather than a polyA tail. Formation of this unique mRNA 3' end requires Stem-loop Binding Protein (SLBP), which directly binds histone pre-mRNA and ...
Harmony R Salzler, Jean M Davidson, Nathan D Montgomery, Robert J Duronio   +3 more
doaj   +1 more source

Coupling of Termination, 3′ Processing, and mRNA Export [PDF]

Molecular and Cellular Biology, 2002
In a screen to identify genes required for mRNA export in Saccharomyces cerevisiae, we isolated an allele of poly(A) polymerase (PAP1) and novel alleles encoding several other 3' processing factors. Many newly isolated and some previously described mutants (rna14-48, rna14-49, rna14-64, rna15-58, and pcf11-1 strains) are defective in polymerase II (Pol
Hammell, C M, Gross, Stefan, Zenklusen, Daniel, Heath, Catherine V, Stutz, Françoise, Moore, Claire, Cole, C N   +6 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I [PDF]

, 2010
Mammalian cleavage factor I (CF Im) is composed of two polypeptides of 25 kDa and either a 59 or 68 kDa subunit (CF Im25, CF Im59, CF Im68). It is part of the cleavage and polyadenylation complex responsible for processing the 39 ends of messenger RNA ...
Antje Ostareck-Lederer, Neuenkirchen, N., Ostareck-Lederer, Antje, Keller, W., Dettwiler, Sabine, Sabine Dettwiler, Fischer, Utz, Martin, Georges, Rüegsegger, U., Fischer, U., Georges Martin, Ashwin Chari, Blank, Diana, Diana Blank, Neuenkirchen, Nils, Blank, D., Utz Fischer, Chari, Ashwin, Ostareck-Lederer, A., Nils Neuenkirchen, Walter Keller, Chari, A., Ursula Rüegsegger, Dettwiler, S., Martin, G., Keller, Walter, Rüegsegger, Ursula   +26 more
core   +1 more source

Roles of Sumoylation in mRNA Processing and Metabolism [PDF]

, 2017
SUMO has gained prominence as a regulator in a number of cellular processes. The roles of sumoylation in RNA metabolism, however, while considerable, remain less well understood. In this chapter we have assembled data from proteomic analyses, localization studies and key functional studies to extend SUMO's role to the area of mRNA processing and ...
Patricia, Richard, Vasupradha, Vethantham, James L, Manley   +2 more
openaire   +2 more sources