Results 11 to 20 of about 3,806,370 (293)
SRAG Functions as a New mRNA Export Co-adaptor [PDF]
, 2012 DEAD box RNA helicases play important roles in many cellular processes including splicing, mRNA export and translation. The two domains of many DEAD box RNA helicases adopt radically different conformations according to whether they are ...
Chang, Chung-Te
core +6 more sources
MMpred: functional miRNA – mRNA interaction analyses by miRNA expression prediction [PDF]
, 2012 Background: MicroRNA (miRNA) directed gene repression is an important mechanism of posttranscriptional regulation. Comprehensive analyses of how microRNA influence biological processes requires paired miRNA-mRNA expression datasets.
Wilson, Paul +5 more
core +8 more sources
Crosstalk Between mRNA 3'-End Processing and Epigenetics
Frontiers in Genetics, 2021 The majority of eukaryotic genes produce multiple mRNA isoforms by using alternative poly(A) sites in a process called alternative polyadenylation (APA).
Lindsey V. Soles, Yongsheng Shi
doaj +1 more source
PABPN1-Dependent mRNA Processing Induces Muscle Wasting. [PDF]
PLoS Genetics, 2016 Poly(A) Binding Protein Nuclear 1 (PABPN1) is a multifunctional regulator of mRNA processing, and its expression levels specifically decline in aging muscles. An expansion mutation in PABPN1 is the genetic cause of oculopharyngeal muscle dystrophy (OPMD),
Muhammad Riaz +6 more
doaj +1 more source
Animal, Fungi, and Plant Genome Sequences Harbor Different Non-Canonical Splice Sites
Cells, 2020 Most protein-encoding genes in eukaryotes contain introns, which are interwoven with exons. Introns need to be removed from initial transcripts in order to generate the final messenger RNA (mRNA), which can be translated into an amino acid sequence ...
Katharina Frey, Boas Pucker
doaj +1 more source
The process of mRNA–tRNA translocation [PDF]
Proceedings of the National Academy of Sciences, 2007 In the elongation cycle of translation, translocation is the process that advances the mRNA–tRNA moiety on the ribosome, to allow the next codon to move into the decoding center. New results obtained by cryoelectron microscopy, interpreted in the light of x-ray structures and kinetic data, allow us to develop a model of the molecular events during ...
Joachim, Frank +4 more
openaire +2 more sources
Aberrant pre-mRNA processing in cancer. [PDF]
J Exp MedDysregulation of the flow of information from genomic DNA to RNA to protein occurs within all cancer types. In this review, we described the current state of understanding of how RNA processing is dysregulated in cancer with a focus on mutations in the RNA splicing factor machinery that are highly prevalent in hematologic malignancies.
Biswas J +3 more
europepmc +3 more sources
Integrating mRNA Processing with Transcription [PDF]
Cell, 2002 The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout ...
Proudfoot, N, Furger, A, Dye, M
openaire +3 more sources
Nutritional Regulation of mRNA Processing [PDF]
The Journal of Nutrition, 2004 Understanding how a cell adapts to dietary energy in the form of carbohydrate versus energy in the form of triacylglycerol requires knowledge of how the activity of the enzymes involved in lipogenesis is regulated. Changes in the activity of these enzymes are largely caused by changes in the rate at which their proteins are synthesized.
Lisa M, Salati +6 more
openaire +2 more sources
Frontiers in Genetics, 2021 HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregulated in resting CD4+ T-cells, the main reservoir of latent HIV in people with HIV (PWH) on antiretroviral therapy (ART). In
Georges Khoury +9 more
doaj +1 more source