Results 211 to 220 of about 874,950 (354)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Cross-feeding options define genome evolution and community assembly of deep groundwater microbiome. [PDF]

Environ Microbiome
Rezaei Somee M, González-Rosales C, Gralka M, Turner S, Bertilsson S, Dopson M, Mehrshad M.   +6 more
europepmc   +1 more source

Whole-Genome Duplication Reshaped Adaptive Evolution in a Relict Plant Species, Cyclocarya Paliurus

, 2023
Yinquan Qu, Xulan Shang, Ziyan Zeng, Yanhao Yu, Guoliang Bian, Wenling Wang, Li Liu, Tian Li, Shengcheng Zhang, Qian Wang, Dejin Xie, Xuequn Chen, Zhenyang Liao, Yibin Wang, Jian Qin, Wanxia Yang, Caowen Sun, Xiangxiang Fu, Xingtan Zhang, Shengzuo Fang   +19 more
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Limited genome evolution of <i>Cryptococcus neoformans</i> following an accidental infection in the research laboratory. [PDF]

ASM Case Rep
Fan Y, Kulkarni M, Zhang SX, Timp W, Sullivan DJ, Smith DFQ, Casadevall A, Hardwick JM.   +7 more
europepmc   +1 more source

Genome-Wide Identification, Characterization, Molecular Evolution and Expression Profiling Analysis of Commd Gene Family in Black Rockfish (Sebastes Schlegelii)

Xuechen Li, Zhentao Chen, Jingrun Pu, Xuangang Wang, Ze Tao, Zhixiang Duan, Gan Yu, Ping Han, Fan Zhang, Haiyang Yu   +9 more
openalex   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Assessment of genome evolution in <i>Bifidobacterium adolescentis</i> indicates genetic adaptation to the human gut. [PDF]

mSystems
Selleri E, Tarracchini C, Petraro S, Mancabelli L, Milani C, Turroni F, Shao Y, Browne HP, Lawley TD, van Sinderen D, Ventura M, Lugli GA.   +11 more
europepmc   +1 more source

Pangenome analysis reveals transposon-driven genome evolution in cotton

Xin He, Zhengyang, Qi, Zhenping, Liu, Xing, Chang, Xianlong, Zhang, Jianying, Li, Maojun, Wang   +6 more
openalex   +1 more source