Results 251 to 260 of about 874,950 (354)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The repetitive genome of the Ixodes ricinus tick reveals transposable elements have driven genome evolution in ticks. [PDF]

Genome Biol
Ronai I, de Paula Baptista R, Paulat NS, Frederick JC, Azagi T, Bakker JW, Dillon KC, Sprong H, Ray DA, Glenn TC.   +9 more
europepmc   +1 more source

Additional file 9: Table S6. of The early events underlying genome evolution in a localized Sinorhizobium meliloti population

, 2016
Nicolás Toro, Francisco Martínez-Abarca, Manuel Fernández-López   +2 more
openalex   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Accelerated Mitochondrial Genome Evolution in Parasitic Barnacles Driven by Adaptive and Non-adaptive Responses. [PDF]

Mol Biol Evol
Jung J, Song S, Kim MY, Kwak H, Chan BKK, Cha SS, Hwang UW, Park JK.   +7 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Genomes and evolution Post-genome, pre-chromosome

Current Opinion in Genetics & Development, 1997
, Ashburner, , Maizels
openaire   +2 more sources

Comparative chloroplast genomics of Teucrium species reveals genome evolution, phylogenetic relationships, and candidate molecular markers. [PDF]

Sci Rep
Hejazi FA, Mohammadi P, Soorni A.
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Comparative chloroplast genome analysis and phylogenomics of Nigerian Aframomum (Zingiberaceae): insights into chloroplast genome evolution and species divergence. [PDF]

BMC Plant Biol
Yaradua SS.
europepmc   +1 more source