Results 141 to 150 of about 155,866 (241)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Tumor Evolution Driving Genome Instability, Immune Interactions, and Response to Radiotherapy. [PDF]

Cancer J
Seed G, Truong F, Riahi R, O'Leary B.
europepmc   +1 more source

Loss of fragile WWOX gene leads to senescence escape and genome instability. [PDF]

Cell Mol Life Sci, 2023
Cheng HC, Huang PH, Lai FJ, Jan MS, Chen YL, Chen SY, Chen WL, Hsu CK, Huang W, Hsu LJ.   +9 more
europepmc   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

A 69.9-kb long inverted repeat increases genome instability in a strain of <i>Lactobacillus crispatus</i>. [PDF]

NAR Genom Bioinform
Colombini L, Santoro F, Tirziu M, Cuppone AM, Pozzi G, Iannelli F.   +5 more
europepmc   +1 more source

Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability. [PDF]

Cells, 2023
Hagkarim NC, Hajkarim MC, Suzuki T, Fujiwara T, Winkler GS, Stewart GS, Grand RJ.   +6 more
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Genome Instability Induced by Topoisomerase Misfunction. [PDF]

Int J Mol Sci
Nitiss KC, Bandak A, Berger JM, Nitiss JL.   +3 more
europepmc   +1 more source

Genome instability-derived genes as a novel prognostic signature for lung adenocarcinoma. [PDF]

Front Cell Dev Biol, 2023
Zhang X, Lam TW, Ting HF.
europepmc   +1 more source

Series on Genomic Instability [PDF]

Nature Cell Biology, 2013
openaire   +2 more sources