Results 201 to 210 of about 155,866 (241)

Alternative Translation Initiation in PRKN Delays the Onset of Parkinson's Disease and Offers a Therapeutic Target

Annals of Neurology, EarlyView.
Objective Biallelic variants in PRKN cause autosomal recessive Parkinson's disease (PD) with a median age at onset of 31 years. When evaluating the 16 previously published carriers of a homozygous deletion of Exon 2 from the International Parkinson's Disease and Movement Disorder Society Gene Database (MDSGene) database, the median age at onset is ...
Arian Hach, Katja Lohmann, Manabu Funayama, Poornima J. Menon, Eva‐Juliane Vollstedt, Teresa Kleinz, Hiroyo Yoshino, Suzanne Lesage, Britta Meier, Carolyn M. Sue, Jean‐Christophe Corvol, Alexis Brice, Nobutaka Hattori, Christine Klein, Aleksandar Rakovic   +14 more
wiley   +1 more source

Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Angewandte Chemie, EarlyView.
A gram‐scale supply of bulbiferamide A, which features a rare N‐acylindole linkage and possesses potent inhibitory activity against Trypanosoma cruzi epimastigotes (IC50 = 4.1 µM)—the causative parasite of Chagas disease—was successfully achieved. Moreover, the cyclization strategy developed in this study facilitated the synthesis of noncanonical ...
Jie Zhang, Hugh Nakamura
wiley   +2 more sources

Impaired dNKAP function drives genome instability and tumorigenic growth in Drosophila epithelia. [PDF]

J Mol Cell Biol
Guo T, Miao C, Liu Z, Duan J, Ma Y, Zhang X, Yang W, Xue M, Deng Q, Guo P, Xi Y, Yang X, Huang X, Ge W.   +13 more
europepmc   +1 more source

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription

Sadurni MM, Jones ML, Pavlou L, Radi M, Kompocholi S, Passaretti P, Gambus A, Gregersen LH, Saponaro M.   +8 more
europepmc   +1 more source

Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability. [PDF]

Mol Genet Genomics
Lafuente-Barquero J, Svejstrup JQ, Luna R, Aguilera A.   +3 more
europepmc   +1 more source

Both Genome Instability and Replicative Senescence Stem from the Shortest Telomere in Telomerase-Negative Cells

Berardi P, Martinez-Fernandez V, Rat A, Rosas Bringas FR, Jolivet P, Langston R, Mattarocci S, Maes A, Aspert T, Zeinoun B, Casier K, Kazemier HG, Charvin G, Doumic M, Chang M, Teixeira MT.   +15 more
europepmc   +1 more source

Detection of genome instability by 53BP1 expression as a long-lasting health effect in human epidermis surrounding radiation-induced skin cancers. [PDF]

J Radiat Res
Matsuda K, Kurohama H, Kuwatsuka Y, Iwanaga A, Murota H, Nakashima M.   +5 more
europepmc   +1 more source

Identification of different classes of genome instability suppressor genes through analysis of DNA damage response markers. [PDF]

G3 (Bethesda)
Li BZ, Kolodner RD, Putnam CD.
europepmc   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Human DNA topoisomerase I poisoning causes R loop-mediated genome instability attenuated by transcription factor IIS. [PDF]

Sci Adv
Duardo RC, Marinello J, Russo M, Morelli S, Pepe S, Guerra F, Gómez-González B, Aguilera A, Capranico G.   +8 more
europepmc   +1 more source